Barrier Creams

Corazza, Monica; Minghetti, Sara; Bianchi, Anna; Virgili, Annarosa; Borghi, Alessandro

doi:10.1097/der.0000000000000078

Cited by 22 publications

(7 citation statements)

References 63 publications

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“…The ability of such a formulation to reduce the dermal uptake of Ni can be attributed to some ingredients such as ceramide 3, cholesterol, hydrogenated polydecene, and fatty acids, which are able to form a more resistant lipid film. Moreover, formulation B is a repairing and protective cream for the epidermal barrier, containing a balanced mixture of fundamental lipids of the epidermis such as ceramide 3, cholesterol, and fatty acids able to restore the skin barrier function [58,59] and palmitamide MEA with soothing activity on irritation and itching [60]. These obtained results concerning the effectiveness of such two products to reduce cutaneous Ni penetration are consistent with our previous study [23].…”

Section: Discussionsupporting

confidence: 88%

Probing the effectiveness of barrier creams against human skin penetration of nickel powder

Magnano

Marussi

Crosera

et al. 2023

Intern J of Cosmetic Sci

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ObjectiveBarrier creams (BCs) are marketed as locally‐applied medical devices or cosmetic products to protect the skin from exposure to chemicals and irritants. Generally, the mechanism of action of such products is mainly due to the formation of a superficial thin film between the skin and the irritant or sensitizer, thus reducing or totally blocking the cutaneous penetration of such agents. Specifically, studies focusing on the effectiveness of commercial protective creams to prevent nickel cutaneous penetration are extremely scarce. The aim of the current work, therefore, is to evaluate the protective role of a commercially available barrier cream for nickel and compare the results with a simple moisturizing, following exposure to Ni powder.MethodsMarketed BCs were evaluated and tested. Human skin absorption of Ni was studied in vitro using static Franz diffusion cells.ResultsOur results demonstrate that the application of both formulations caused a reduction of Ni inside the skin (8.00 ± 3.35 μg·cm‐2 for the barrier cream and 22.6 ± 12.6 μg·cm‐2 for the general moisturizing product), with the specialized barrier cream being statistically (p = 0.015) more efficient on forming a protective barrier, thus evidencing the importance of some ingredients of such formulations on the nickel dermal accumulation.ConclusionsThe composition of the formulations based on film forming or chelating agents may play an imperative role to reduce the cutaneous penetration of Ni.

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Section: Discussionsupporting

confidence: 88%

Probing the effectiveness of barrier creams against human skin penetration of nickel powder

Magnano

Marussi

Crosera

et al. 2023

Intern J of Cosmetic Sci

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“…The emollient acts as a physical barrier to lower the Trans Epidermal Water Loss (TEWL), which provides water content recharge in the corneum stratum, so it requires the use of emollient after washing hands to reduce the increase in dermatitis due to repeated washing of hands in response to COVID-19 8 . The effectiveness of various types of emollients has been studied by other authors; according to Corazza, 2014, emollients have been shown to protect against detergents such as sodium lauryl sulfate (SLS) and hydrophilic substances such as NaOH on wet work, but in a study written in article 9 . Stearate acid contained in the emollient, when reacting with NaOH, can increase irritation and then cause irritant contact dermatitis 9 .…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Emollient Topical Therapy on Hand Dermatitis Events

Pranesti,

Sutrisna,

Faradisa

et al. 2024

magnamed

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Background: Clinically, hand dermatitis manifests as either irritant contact dermatitis (ICD) or allergy contact dermatitis (ACD). Patients with hand dermatitis typically use emollients to reduce transepidermal water loss (TEWL).Objective: This investigation aims to evaluate the efficacy of emollient topical therapy on hand dermatitis.Methods: The study's design was based on a literature review, and the research samples were obtained through online searches on Google Scholar, PubMed, and ScienceDirect.Results: 495 items were subsequently excluded based on the restriction criteria. We obtained eight research articles for evaluation. Hand Eczema Severity Index (HECSI), TEWL, Dermatology Life Quality Index (DLQI), Health-related quality of life (HRQoL), Modified Total Lesion Symptom Score (mTLSS), Investigator Global Assessment (IGA), and Visual analog score (VAS) were used to measure hand dermatitis, and there was a significant increase in these measurements for emollients. In the conclusion of the eight articles, six stated that they were significant, and two stated that emollients were effectively used as topical therapy.Conclusion: Emollients typically act on the epidermis, particularly the stratum corneum, which can reduce TEWL so that antigen penetration and inflammation spread are not facilitated.

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“…BCs are used to prevent the irritant effect caused by occupational exposure and are recommended for application before and during work. Some authors call them prework creams [8,9,10]. They have also been called ‘invisible gloves' but the term ‘skin protective creams' is more appropriate [10].…”

Section: Introductionmentioning

confidence: 99%

“…Some authors call them prework creams [8,9,10]. They have also been called ‘invisible gloves' but the term ‘skin protective creams' is more appropriate [10]. The objective of the BCs is to inhibit or delay cutaneous penetration of substances which could have deleterious effects at the time of skin contact or induce systemic effects due to percutaneous absorption [11].…”

Section: Introductionmentioning

confidence: 99%

“…BCs are therefore used to reduce the irritant effect of substances, preventing irritant contact dermatitis. Barrier repair creams, also called ‘regeneration creams', ‘conditioning creams', ‘emollients' or ‘moisturizers' [10], are intended to enhance hydration by way of the hygroscopic action of humectants, such as amino acids, urea, glycerine, lactic acid (LA) or pyrrolidone carboxylic acid [12], and to restore the skin's natural barrier. They are especially recommended for use after work [13].…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Barrier Creams against Irritant Contact Dermatitis

Mostosi

Simonart

2016

Dermatology

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Introduction: Skin tissue is frequently exposed to various irritant substances in the workplace, particularly in wet work, which can lead to the development of occupational contact dermatitis. ‘Barrier' creams (BCs) are well known, and their applications are still the subject of many studies and controversies. Methods: We searched all controlled trials investigating BCs against cutaneous irritants in humans published between 1956 and December 2014 from MEDLINE, PubMed, reference lists and existing reviews. Results: Thirty-nine studies about the effects of BCs against skin irritants in humans were selected. Among these, 27 trials in healthy volunteers were found to show many differences with regard to BCs and irritants used, their quantities, test locations, procedures and assessment methods. Finally, 14 patch test trials assessed by clinical scoring and evaporimetry emerged. Although the findings were generally positive, only few findings could be cross-checked from all the data, and vehicles seem to be as effective as BCs. Conclusion: Although this review highlights the poor quality and the lack of standardization of most studies, BCs seem to have protective effects against irritants. Further well-designed, adequately powered randomized controlled trials with clinical and biophysical assessments are required.

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Barrier Creams

Cited by 22 publications

References 63 publications

Probing the effectiveness of barrier creams against human skin penetration of nickel powder

Probing the effectiveness of barrier creams against human skin penetration of nickel powder

Effectiveness of Emollient Topical Therapy on Hand Dermatitis Events

Effectiveness of Barrier Creams against Irritant Contact Dermatitis

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