Effectiveness of Barrier Creams against Irritant Contact Dermatitis

Mostosi, Christian; Simonart, Thierry

doi:10.1159/000444219

Cited by 30 publications

(13 citation statements)

References 56 publications

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“…Practical literature‐based recommendations referring to this are summarized in Table 6. Regarding barrier creams, evidence for their efficacy 65,66 is limited. They may only be effective against certain irritants and may sometimes even intensify the irritant skin response 67–69 .…”

Section: Preventionmentioning

confidence: 99%

Guidelines for diagnosis, prevention, and treatment of hand eczema

et al. 2022

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Funding informationNo support was given by any medical company for development of this document. All meetings were virtual meetings, therefore there were no costs. All participants in the working group filled in a structured form to declare financial or non-financial interests. Disclosures are given in the Supporting information. The Guidelines were approved by the executive committee of the ESCD in

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Section: Preventionmentioning

confidence: 99%

Guidelines for diagnosis, prevention, and treatment of hand eczema

et al. 2022

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“…Thus, development of allergic CD skin lesions includes complex immune pathways, influenced by both genetic and environmental triggers ( 14 ). There are prominent roles of genetic variations and mutations (predominantly filaggrin mutations) and impaired barrier function (e.g., aberrancies in epidermal pH buffering capabilities), which may promote bacterial biofilms and create an environment favoring sensitization ( 13 , 22 , 23 ). Regarding genetics, according to research data, filaggrin mutations (R501X, 2282del4, and R2447X) were identified in 16.9% of patients with hand eczema and were significantly associated with skin lesions (skin fissures on the fingers and heels).…”

Section: The Pathomechanisms Of Contact Dermatitismentioning

confidence: 99%

Irritant and Allergic Contact Dermatitis – Skin Lesion Characteristics

Novak-Bilić

Vučić

Japundžić

et al. 2018

ACC

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SUMMARY – Contact skin lesions may be the consequences of contact with various irritants or allergens, or due to other factors (e.g., UV radiation, microbials), intrinsic factors (e.g., in autoimmune responses), or even their combination. There are many substances related to irritant contact dermatitis (CD), causing irritant or toxic effects, e.g., chemical and physical agents, plants, phototoxic agents, airborne irritants, etc. Impaired barrier function (e.g., aberrancies in epidermal pH buffering capabilities) also participates by promoting bacterial biofilms and creating an environment favoring sensitization. Development of allergic CD skin lesions includes complex immune pathways and inflammatory mediators, influenced by both genetic (predominantly filaggrin mutations) and environmental triggers. In the pathogenesis of allergic CD, antimicrobial peptides play a prominent role; they are produced by various skin cells (e.g., keratinocytes, sebocytes) and move to inflamed lesions during an inflammation process. Also, in allergic CD skin lesions, the skin shows different types of immune responses to individual allergens, although clinical manifestations do not depend on the causative allergen type, e.g., nickel stimulates immune activation primarily of the Th1/Th17 and Th22 components. Also important are alarmins, proteases, immunoproteomes, lipids, natural moisturizing factors, tight junctions, smoking, etc. We expect that future perspectives may reveal new pathogenetic factors and scientific data important for the workup and treatment of patients with CD.

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“…. Barrier creams have demonstrated effectiveness in maintaining skin hydration and providing protection against skin barrier damage caused by irritants . By restoring the disrupted skin barrier, barrier creams, such as the one tested in the current study, can break the cycle of epidermal damage in incontinent patients and allow healing of the skin and reduction in IAD .…”

Section: Section 4: the Use Of A Dermo‐cosmetic Product Containing Rhmentioning

confidence: 94%

Gerontodermatology: the fragility of the epidermis in older adults

Katoh

Tennstedt

Kan³

et al. 2018

Acad Dermatol Venereol

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The proportion of adults over 60 years of age is rapidly increasing and is estimated to reach approximately one-sixth of the global population by 2030. An ageing population is a real challenge for healthcare resources, including dermatologists and geriatricians, as age-related changes in skin integrity and barrier function make older adults more susceptible to developing skin pathologies such as pruritus, dermatitis and infections. Fragile skin arises from several interlinked causes, including age-related changes in skin barrier integrity, previous and current lifestyle choices, skin pathologies and medical interventions. Dermo-cosmetics can play a key role in enhancing skin care regimens and preventing pathologies in this age group. In vitro studies, clinical, and in-daily clinical practice studies of dermo-cosmetics have shown them to be effective in many skin conditions in older adults, like xerosis and pruritus. Incontinence-associated dermatitis (IAD), a common condition arising from contact with irritants such as urine and faeces which can significantly impact the quality of life of sufferers, can also be improved with a barrier cream in incontinent patients aged 70 years and older. This supplement focuses on the increased fragility of older skin, the development of common skin pathologies and the efficacy and tolerance of dermo-cosmetic products in older adults.JEADV alcohol consumption and sun exposure), medical procedures (e.g. surgery) and underlying pathologies can all contribute to the development of fragile skin. While not necessarily associated with disease per se, most patients presenting to dermatologists with fragile skin have pathological conditions such as acne, psoriasis and atopic dermatitis. 4 However, surveys reveal that a substantial proportion of people have perceived fragile skin, which, while not associated with disease, can cause redness, tightness, dryness and itching. 5,6 Globally, the incidence of fragile skin in adults has been estimated as 25-52%, across skin types and age groups. [4][5][6] In older adults, skin ageing makes individuals more vulnerable to develop fragile skin and associated pathologies resulting from impaired skin barrier function. The mechanisms and clinical relevance of age-related skin deterioration, the prevalence of skin disorders in older adults in Europe and recent in vitro, clinical and in-daily clinical practice studies of fragile skin in this age group will be covered in this supplement. Section 1: Fragile skin in older adultsIn addition to internal age-related changes in skin structure and functionality, physiological, circumstantial, pathological and iatrogenic fragile skin causes also contribute to the weakening of the epidermis and skin barrier in older adults. Physiological fragile skinOlder adults experience physiological fragile skin, as declines in the immune system function within the epidermis, and changes in epidermal and dermal structure contribute to a reduction in the effectiveness of the skin barrier function. 7 During adulthood, the skin ...

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Effectiveness of Barrier Creams against Irritant Contact Dermatitis

Cited by 30 publications

References 56 publications

Guidelines for diagnosis, prevention, and treatment of hand eczema

Guidelines for diagnosis, prevention, and treatment of hand eczema

Irritant and Allergic Contact Dermatitis – Skin Lesion Characteristics

Gerontodermatology: the fragility of the epidermis in older adults

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