Barley Intake Induces Bile Acid Excretion by Reduced Expression of Intestinal ASBT and NPC1L1 in C57BL/6J Mice

Hoang, Minh Hien; Houng, Soung Jin; Jun, Hee-Jin; Lee, Ji Hae; Choi, Jin Woong; Kim, Sohee; Kim, Yong Ro; Lee, Sung Joon

doi:10.1021/jf200681n

Cited by 39 publications

(34 citation statements)

References 50 publications

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“…Furthermore, Niemann-Pick C1-like 1 protein (NPC1L1), a cholesterol transporter, plays an important role in the absorption of dietary cholesterol in small intestinal epithelium. 30 Curcumin, a type of polyphenol, was shown to inhibit uptake of cholesterol by decreasing mRNA expression levels of NPC1L1 in Caco-2 cells. 31 Our results suggested the possibility that AS leaves have a modulating effect on cholesterol metabolism associated with NPC1L1 activity or other novel metabolic pathways.…”

Section: Discussionmentioning

confidence: 99%

Antihyperlipidemic effect of Acanthopanax senticosus (Rupr. et Maxim) Harms leaves in high‐fat‐diet fed mice

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Antihyperlipidemic effect of Acanthopanax senticosus (Rupr. et Maxim) Harms leaves in high‐fat‐diet fed mice

et al. 2016

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“…Faecal bile acids were extracted as described by Hoang et al . A kit ordered from Spinreact (Girona, Spain) was employed to measure the total amount of faecal bile acids.…”

Section: Methodsmentioning

confidence: 99%

“…The amount of HDL-C was determined in the supernatant. The nHDL-C value was generated from TC subtracting HDL-C. Faecal bile acids were extracted as described by Hoang et al [15] A kit ordered from Spinreact (Girona, Spain) was employed to measure the total amount of faecal bile acids.…”

Section: Plasma Hepatic and Faecal Lipid Concentrationsmentioning

confidence: 99%

Co-administrating apigenin in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters

Wong

Tan

Lin

et al. 2018

Journal of Pharmacy and Pharmacology

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“…Bile acid is known to be a regulator of cysteine sulfinic acid decarboxylase via mechanisms shared in part with CYP7A1, and may affect cholesterol via CYP7A1 through the downregulation of the hepatic FXR/SHP pathway (33,34). Bile acid levels were shown to be increased with an increased expression of BSEP and the expression of NTCP and ASBT are also known to be involved in the regulation of bile acid metabolism (35,36,37). In the present study, the expression of BSEP, Caveolin-1 and SHP significantly increased, while that of ASBT, NTCP and CYP7A1 decreased, in accordance with previous studies.…”

Section: Discussionmentioning

confidence: 99%

Bile acid promotes liver regeneration via farnesoid X receptor signaling pathways in rats

Ding

Yang

et al. 2015

Molecular Medicine Reports

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Abstract. Bile acids, which are synthesized from cholesterol in the hepatocytes of the liver, are amphipathic molecules with a steroid backbone. Studies have shown that bile acid exhibits important effects on liver regeneration. However, the mechanism underlying these effects remains unclear. The aim of the present study was to investigate the effect of bile acid and the farnesoid X receptor (FXR) on hepatic regeneration and lipid metabolism. Rats were fed with 0.2% bile acid or glucose for 7 days and then subjected to a 50 or 70% hepatectomy. Hepatic regeneration rate, serum and liver levels of bile acid, and expression of FXR and Caveolin-1, were detected at 24, 48 or 72 h following hepatectomy. The expression of proliferating cell nuclear antigen (PCNA) in the liver was measured using immunohistochemistry at the end of the study. Hepatocytes isolated from rats were treated with bile acid, glucose, FXR agonist and FXR antagonist, separately or in combination. Lipid metabolism, the expression of members of the FXR signaling pathway and energy metabolism-related factors were measured using ELISA kits or western blotting. Bile acid significantly increased the hepatic regeneration rate and the expression of FXR, Caveolin-1 and PCNA. Levels of total cholesterol and high density lipoprotein were increased in bile acid-or FXR agonist-treated hepatocytes in vitro. Levels of triglyceride, low density lipoprotein and free fatty acid were decreased. In addition, bile acid and FXR agonists increased the expression of bile salt export pump and small heterodimer partner, and downregulated the expression of apical sodium-dependent bile acid transporter, Na + /taurocholate cotransporting polypeptide and cholesterol 7α-hydroxylase. These results suggested that physiological concentrations of bile acid may promote liver regeneration via FXR signaling pathways, and may be associated with energy metabolism. IntroductionLiver regeneration is important in the recovery from injury induced by surgery, trauma, poisoning, infection, necrosis or liver transplantation (1). Consequently, research investigating the improvement of the regeneration ability of the liver, is of great significance. During regeneration, quiescent mature hepatocytes reenter the cell cycle in order to proliferate and divide, thus leading to hepatic regeneration without the involvement of stem cells. Although the exact mechanisms have not been fully characterized, a study demonstrated that liver regeneration primarily comprises cell proliferation, lipid metabolism, various growth factors, and a number of cytokines and their signaling pathways (2).Bile acid, which is synthesized from cholesterol, is the chief components of bile. The primary functions of bile are to digest the fat soluble molecules in food and to aid in the intestinal absorption of lipids in vivo. Recent studies have shown that bile acid acts as a signaling molecule by activating signaling pathways, and that it participates in the process of liver regeneration (3,4). A number of transport proteins fo...

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Barley Intake Induces Bile Acid Excretion by Reduced Expression of Intestinal ASBT and NPC1L1 in C57BL/6J Mice

Cited by 39 publications

References 50 publications

Antihyperlipidemic effect of Acanthopanax senticosus (Rupr. et Maxim) Harms leaves in high‐fat‐diet fed mice

Antihyperlipidemic effect of Acanthopanax senticosus (Rupr. et Maxim) Harms leaves in high‐fat‐diet fed mice

Co-administrating apigenin in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters

Bile acid promotes liver regeneration via farnesoid X receptor signaling pathways in rats

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