Bark extract mediated green synthesis of silver nanoparticles: Evaluation of antimicrobial activity and antiproliferative response against osteosarcoma

Nayak, Debasis; Ashe, Sarbani; Rauta, Pradipta Ranjan; Kumari, Manisha; Nayak, Bismita

doi:10.1016/j.msec.2015.08.022

Cited by 267 publications

(128 citation statements)

References 45 publications

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“…The study found a direct dose dependence between increased (AgNP) concentration to cytotoxicity against the cancer cell line, with a significant 85% of cell mortality, although anticancer activity mechanism is yet to be understood. Similarly, Nayak et al 34 synthesized crystalline and spherical AgNPs using bark extracts of Ficus benghalensis and Azadirachta indica and observed antibacterial activity against gram-positive and -negative bacteria, in addition to cytotoxicity against osteosarcoma MG-63 cell line.…”

Section: Nanoparticlesmentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

474

334

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The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising alternative to antibacterial reagents because of their exhibited antibacterial activity in several biomedical applications, including drug and gene delivery, tissue engineering, and imaging. Moreover, nanomaterial research has led to reports of a possible relationship between the morphological characteristics of a nanomaterial and the magnitude of its delivered toxicity. However, conventional synthesis of nanoparticles requires harsh chemicals and costly energy consumption. Additionally, the exact relationship between toxicity and morphology of nanomaterials has not been well established. Here, we review the recent advancements in synthesis techniques for silver, gold, copper, titanium, zinc oxide, and magnesium oxide nanomaterials and composites, with a focus on the toxicity exhibited by nanomaterials of multidimensions. This article highlights the benefits of selecting each material or metal-based composite for certain applications while also addressing possible setbacks and the toxic effects of the nanomaterials on the environment.

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Section: Nanoparticlesmentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

474

334

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“…58 The biologically synthesized metallic NPs are biocompatible and potentially safe for human therapeutic use. A plethora of literature highlights the antimicrobial activities of biogenic metallic NPs ( 60 Ag NPs synthesized using leaves extract of Skimmia laureola, 61 root extract of Delphinium denudatum, 62 Styrax benzoin extract 63 and Rosa chinensis flower extract 64 showed potent antibacterial effects against a spectrum of Gram-positive and Gramnegative human pathogenic bacteria. Ag NPs synthesized using Caesalpinia sappan extract served as a potential novel nanoantibiotic against MRSA.…”

Section: Antibacterial Activities Of Ecofriendly Green Npsmentioning

confidence: 99%

Nanomaterials for alternative antibacterial therapy

Hemeg

2017

IJN

405

262

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Despite an array of cogent antibiotics, bacterial infections, notably those produced by nosocomial pathogens, still remain a leading factor of morbidity and mortality around the globe. They target the severely ill, hospitalized and immunocompromised patients with incapacitated immune system, who are prone to infections. The choice of antimicrobial therapy is largely empirical and not devoid of toxicity, hypersensitivity, teratogenicity and/or mutagenicity. The emergence of multidrug-resistant bacteria further intensifies the clinical predicament as it directly impacts public health due to diminished potency of current antibiotics. In addition, there is an escalating concern with respect to biofilm-associated infections that are refractory to the presently available antimicrobial armory, leaving almost no therapeutic option. Hence, there is a dire need to develop alternate antibacterial agents. The past decade has witnessed a substantial upsurge in the global use of nanomedicines as innovative tools for combating the high rates of antimicrobial resistance. Antibacterial activity of metal and metal oxide nanoparticles (NPs) has been extensively reported. The microbes are eliminated either by microbicidal effects of the NPs, such as release of free metal ions culminating in cell membrane damage, DNA interactions or free radical generation, or by microbiostatic effects coupled with killing potentiated by the host’s immune system. This review encompasses the magnitude of multidrug resistance in nosocomial infections, bacterial evasion of the host immune system, mechanisms used by bacteria to develop drug resistance and the use of nanomaterials based on metals to overcome these challenges. The diverse annihilative effects of conventional and biogenic metal NPs for antibacterial activity are also discussed. The use of polymer-based nanomaterials and nanocomposites, alone or functionalized with ligands, antibodies or antibiotics, as alternative antimicrobial agents for treating severe bacterial infections is also discussed. Combinatorial therapy with metallic NPs, as adjunct to the existing antibiotics, may aid to restrain the mounting menace of bacterial resistance and nosocomial threat.

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“…Silver nanoparticles (AgNPs) have encouraging application in curative efficacy like wound care, skin cancer and breast cancer 21 . Moreover, these are being used as bone cementing and prosthetic materials for fast recovery.…”

Section: Cytotoxic Activity Against Pc-3 Cell Linementioning

confidence: 99%

Novel Biogenic Synthesis of Agnps From Seed Extract of Eugenia Uniflora L.: In Vitro Assessment of Their Antioxidant, Antimicrobial and Cytotoxic Potential

Dugganaboyana¹,

Sharanya²,

Kumar³

et al. 2017

Int. Res. J. Pharm.

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Here, we explored the medicinal uses of the novel biogenic silver nanoparticles of Eugenia uniflora L. (E. uniflora) seed extract as a cost effective, eco-friendly, reducing and stabilizing compounds. This study describes the synthesis of silver nanoparticles from Eugenia uniflora L. (E. uniflora) seed extract and their antioxidant, antibacterial and cytotoxic potential. Biosynthesis of AgNPs was monitored by UV-visible spectroscopy which revealed intense surface plasmon resonance bands at 447 nm and X-ray diffraction were employed to identify various functional groups and crystalline nature of AgNPs. Scanning electron microscopy studies demonstrated that synthesized particles were crystalline in nature with average size of 78-100nm. In vitro antioxidant effects were analyzed by butylated hydroxytoluene (BHT)) and 2,2-diphenyl-1-picrylhydrazyl (DPPH), which exhibited antioxidant activity there in the particles could scavenges the stable free radical DPPH of 75% to that o positive control BHT. The value of 50% inhibition concentration (IC50) of Standard BHT is 65.55 and E. uniflora is 38.63µg/ml. The antibacterial activity of green AgNPs displayed better zone of inhibition against selected human pathogens. The present study also investigated the toxicity effect of biogenic AgNPs against human prostate cancer cells (PC-3) and the inhibitory concentrations (IC50) were found to be 6.25μg/ml, respectively. It could be concluded that E. uniflora seed extract AgNPs can be used efficiently for potential antioxidant, antibacterial and cytotoxic potential AgNPs with potent biomedical applications.

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Bark extract mediated green synthesis of silver nanoparticles: Evaluation of antimicrobial activity and antiproliferative response against osteosarcoma

Cited by 267 publications

References 45 publications

Antibacterial properties and toxicity from metallic nanomaterials

Antibacterial properties and toxicity from metallic nanomaterials

Nanomaterials for alternative antibacterial therapy

Novel Biogenic Synthesis of Agnps From Seed Extract of Eugenia Uniflora L.: In Vitro Assessment of Their Antioxidant, Antimicrobial and Cytotoxic Potential

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