Bark and Fruit Extracts ofGmelina arborea. Protect Liver Cells from Oxidative Stress

Abstract

The effect of Gmelina arborea Roxb. (Verbenaceae) bark and fruit aqueous extracts on paraquat-and hydrogen peroxide-induced oxidative stress was investigated using liver slice culture. Both paraquat and hydrogen peroxide were found to be cytotoxic as measured by release of lactate dehydrogenase from liver slice culture. Addition of bark and fruit extracts along with these cytotoxic agents led to a decrease in lactate dehydrogenase release. Activities of three antioxidant enzymes, namely superoxide dismutase, catalase, and glutathione reductase, were found to increase on treatment with these prooxidants. Addition of the plant extracts along with the pro-oxidants suppressed the enzyme activities. The extracts also displayed antioxidant activity in in vitro radical scavenging assays. Results indicate that Gmelina bark and fruit extracts protected liver slice culture cells by alleviating oxidative stress-induced damage to liver cells.

Toxicity study and analgesic activity of Gmelina arborea extract and its fractions

“…[10] Crude extracts of the plant are reported to possess wound-healing properties, [11] antidiarrheal activity, [12] antioxidant activity, [13] antiulcer activity, [14] and antidiabetic activity. [15] Toxicity studies of aqueous extract have been reported.…”

Anticonvulsant and Antioxidant Effects of Methanol Extract of Stems of <i>G. arborea Roxb.</i>

“…[6][7][8][9] Heartwood of Gmelina is used as an ingredient in many well-known Ayurvedic and herbal preparations like Dashmula and Chyawanprasha and is therefore much used in a variety of diseases. [6,10] Pharmacological studies indicating antiinflammatory [11,12], antioxidant [13], antimicrobial [14], anti-ulcer [15] and wound healing [16] potential of different plant parts are well reported. The plant extracts are also reported for their hypolipidemic activity [17], antidiabetic activity [18], anti-diarrhoeal activity [19] and immunomodulatory activity [20].…”

Toxicological studies on aqueous extract ofGmelina arboreain rodents

“…Different extracts of the plant are reported to have wound-healing properties (Shirwaikar et al, 2003), antidiarrheal activity (Agunua et al, 2005), and antioxidant activity (Sinha et al, 2006).…”