Barium titanate nanoparticles: promising multitasking vectors in nanomedicine

Abstract

Ceramic materials based on perovskite-like oxides have traditionally been the object of intense interest for their applicability in electrical and electronic devices. Due to its high dielectric constant and piezoelectric features, barium titanate (BaTiO3) is probably one of the most studied compounds of this family. Recently, an increasing number of studies have been focused on the exploitation of barium titanate nanoparticles (BTNPs) in the biomedical field, owing to the high biocompatibility of BTNPs and their peculiar non-linear optical properties that have encouraged their use as nanocarriers for drug delivery and as label-free imaging probes. In this review, we summarize all the recent findings about these 'smart' nanoparticles, including the latest, most promising potential as nanotransducers for cell stimulation.

Novel cellulose nanofibers/barium titanate nanoparticles nanocomposites and their electrical properties

“…Due to the interesting properties of BT, especially the nano‐structured ones, polymers nanocomposites containing BT nanoparticles have been studied using different synthetic polymers to prepare high‐ k flexible materials for different applications such as pyroelectric sensors, nonvolatile memories, and surface acoustic wave devices; the studied polymers included poly(vinylidene fluoride), fluoro‐polydopamine, oligothiophene polymer, polymethylmethacrylate, epoxy; poly(vinylidenefluoride‐ co ‐hexafluoropropylene), and interpenetrating polyurethane polymer.…”

“…[9][10][11][12][13] Barium titanate is characterized not only by its variable electrical and optical properties, but also by its non-toxic nature in contrast with the environmental burdened ferroelectric Pb-based ceramics. [14][15][16] Due to the interesting properties of BT, especially the nano-structured ones, polymers nanocomposites containing BT nanoparticles have been studied using different synthetic polymers to prepare high-k flexible materials for different applications such as pyroelectric sensors, nonvolatile memories, and surface acoustic wave devices [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] ; the studied polymers included poly(vinylidene fluoride), fluoro-polydopamine, oligothiophene polymer, polymethylmethacrylate, epoxy; poly(vinylidenefluoride-cohexafluoropropylene), and interpenetrating polyurethane polymer.…”

Laser Recording of Subcellular Neuron Activities

“…Finally, laser recording of stimulated neuron activities was performed, in which a low-intensity pulsed ultrasound was applied to activate neurons absorbed with piezoelectric BaTiO3 nanoparticles, which have been used previously for wireless, non-invasive, and targeted electric stimulation in neurons [34][35][36] . A number of studies have utilized BaTiO3 nanoparticles for drug delivery, imaging in ex vivo tissues, in vitro cell cultures, and in vivo animal or tissue models, due to their high biocompatibility [37][38][39][40] . To ensure that the BaTiO3 nanoparticles were well attached to the cell membrane, the BaTiO3 nanoparticles were first coated with a lipid layer DSPE-PEG-5000…”

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

“…Despite some problems with relatively low tumor uptake in some cancer applications, there is today a number of promising alternatives that have been tested or are under the development [57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90]. Below follows a presentation of important and interesting NP alternatives suitable for PCa and BC, some of which already have been tested for these type of diseases while some are still to be explored more thoroughly.…”