Barium ion cross-linked alginate-carboxymethyl cellulose composites for controlled release of anticancer drug methotrexate

Kahya, Nilay; Gölcü, Ayşegül; Erim, F. Bedia

doi:10.1016/j.jddst.2019.101324

Cited by 21 publications

(10 citation statements)

References 36 publications

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“…The researchers have prepared many formulations and systems to promote actives delivery efficiency via oral routes to beat oral drug delivery limitations. The recent literature includes preparations such as cationic cyclodextrin/ALG/CS nanoflowers/5-fluorouracil [ 135 ], hydroxyethylacryl CS/SA hydrogel/paracetamol [ 136 ], pH-sensitive nanocomposite using SA/pectin/tannic acid(TA)/silver(Ag)/propranolol [ 137 ], Cyperus esculentus starch-ALG/ibuprofen [ 138 ], calcium alginate (CA)/SWCNT-GI/curcumin [ 139 ], thiol-modified SA microspheres/bovine serum albumin [ 140 ], vitamin B12 modified amphiphilic SA nanoparticles/insulin [ 141 ], thiolated SA nanoparticles/docetaxel [ 142 ], CA beads/cetuximab/octreotide [ 143 ], ALG/barium ion/methotrexate [ 144 ], CS/CA/liraglutide [ 145 ], nano pol cellulose (CMC)/ALG/CS [ 146 ].…”

Section: Current Advancements In Alg Formulations In Drug Deliverymentioning

confidence: 99%

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Abourehab

Singh

Pramanik

et al. 2022

IJMS

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Biopolymeric nanoparticulate systems hold favorable carrier properties for active delivery. The enhancement in the research interest in alginate formulations in biomedical and pharmaceutical research, owing to its biodegradable, biocompatible, and bioadhesive characteristics, reiterates its future use as an efficient drug delivery matrix. Alginates, obtained from natural sources, are the colloidal polysaccharide group, which are water-soluble, non-toxic, and non-irritant. These are linear copolymeric blocks of α-(1→4)-linked l-guluronic acid (G) and β-(1→4)-linked d-mannuronic acid (M) residues. Owing to the monosaccharide sequencing and the enzymatically governed reactions, alginates are well-known as an essential bio-polymer group for multifarious biomedical implementations. Additionally, alginate’s bio-adhesive property makes it significant in the pharmaceutical industry. Alginate has shown immense potential in wound healing and drug delivery applications to date because its gel-forming ability maintains the structural resemblance to the extracellular matrices in tissues and can be altered to perform numerous crucial functions. The initial section of this review will deliver a perception of the extraction source and alginate’s remarkable properties. Furthermore, we have aspired to discuss the current literature on alginate utilization as a biopolymeric carrier for drug delivery through numerous administration routes. Finally, the latest investigations on alginate composite utilization in wound healing are addressed.

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Section: Current Advancements In Alg Formulations In Drug Deliverymentioning

confidence: 99%

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Abourehab

Singh

Pramanik

et al. 2022

IJMS

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“…In this case, the tablets disintegrate and the drug is dispersed allowing slow and controlled release. Similarly, Nilay Kahya et al prepared sodium alginate (NaAlg)/sodium carboxymethyl cellulose (NaCMC) composite hydrogel beads by crosslinking with a barium chloride solution to carry methotrexate [ 28 ]. T.S.…”

Section: Alginic Acid and Its Derivativesmentioning

confidence: 99%

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

et al. 2020

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In recent years, researchers across various fields have shown a keen interest in the exploitation of biocompatible natural polymer materials, especially the development and application of seaweed polysaccharides. Seaweed polysaccharides are a multi-component mixture composed of one or more monosaccharides, which have the functions of being anti-virus, anti-tumor, anti-mutation, anti-radiation and enhancing immunity. These biological activities allow them to be applied in various controllable and sustained anti-inflammatory and anticancer drug delivery systems, such as seaweed polysaccharide-based nanoparticles, microspheres and gels, etc. This review summarizes the advantages of alginic acid, carrageenan and other seaweed polysaccharides, and focuses on their application in gel drug delivery systems (such as nanogels, microgels and hydrogels). In addition, recent literature reports and applications of seaweed polysaccharides are also discussed.

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Section: Introductionmentioning

confidence: 99%

“…In this framework, there are some published papers reporting the synthesis and physicochemical characterization of complexes of MTX with bioactive cations such as Sr, Zn, Cu, or Pt [ 21 , 22 , 23 , 24 ]. Exceptionally, in two of these works the authors addressed some anti-proliferation studies and loaded them into a controlled delivery system [ 23 , 24 ]. Consequently, the additional positive effects of MTX complexes coming from the bioactive cation have not been explored yet and research on this topic is required prior to their final biomedical application.…”

Section: Introductionmentioning

confidence: 99%

Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments

Fernández‐Villa

Ramírez-Jiménez

Aranaz

et al. 2022

IJMS

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Methotrexate (MTX) administration is the gold standard treatment for rheumatoid arthritis (RA), but its effects are limited to preventing the progression of the disease. Therefore, effective regenerative therapies for damaged tissues are still to be developed. In this regard, MTX complexes of general molecular formula M(MTX)·xH2O, where M = Sr, Zn, or Mg, were synthesized and physicochemically characterized by TGA, XRD, NMR, ATR–FTIR, and EDAX spectroscopies. Characterization results demonstrated the coordination between the different cations and MTX via two monodentate bonds with the carboxylate groups of MTX. Cation complexation provided MTX with new bioactive properties such as increasing the deposition of glycosaminoglycans (GAGs) and alternative anti-inflammatory capacities, without compromising the immunosuppressant properties of MTX on macrophages. Lastly, these new complexes were loaded into spray-dried chitosan microparticles as a proof of concept that they can be encapsulated and further delivered in situ in RA-affected joints, envisioning them as a suitable alternative to oral MTX therapy.

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Barium ion cross-linked alginate-carboxymethyl cellulose composites for controlled release of anticancer drug methotrexate

Cited by 21 publications

References 36 publications

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments

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