Bariatric Left Gastric Artery Embolization for the Treatment of Obesity: A Review of Gut Hormone Involvement in Energy Homeostasis

Anton, Kevin; Rahman, Tariq; Bhanushali, Ashok; Patel, Aalpen A.

doi:10.2214/ajr.15.14331

Cited by 23 publications

(11 citation statements)

References 52 publications

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“…A retrospective human study [2] of patients being treated for gastrointestinal (GI) bleeding found a significant reduction in body weight 3 months post-procedure for patients undergoing left gastric artery embolization (7.3% reduction, n=19) compared with a control group undergoing embolization of another artery (2% reduction, n=28). Multiple animal trials, summarized by Anton, et al [3], have shown similar reductions in body weight and/or ghrelin levels with left gastric artery embolization.…”

Section: Introductionmentioning

confidence: 93%

Gastric Artery Embolization: Studying Effects of Catheter Type and Injection Rate on Bead Distributions within a Benchtop Arterial Model

Jernigan

Osborne

Buckner

2020

Preprint

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Aims: To investigate the effect of catheter type and injection method on microsphere distributions, specifically vessel targeting accuracy. Materials and Methods: The study utilized three catheter types (a standard micro-catheter, a Surefire anti-reflux catheter, and an Endobar occlusion balloon catheter) and both manual and computer-controlled injection schemes. A closed-loop, dynamically pressurized surrogate arterial system was assembled to replicate arterial flow for bariatric embolization procedures. Four vessel branches immediately distal to the injection site were targeted for embolization. Embolic microspheres were injected into the model using three catheter types (a standard micro-catheter, a Surefire anti-reflux catheter, and an Endobar occlusion balloon catheter) and both manual and computer-controlled injections. Results: Across all injection methods, the catheter effect on the proportion of microspheres to target vessels (vs. non-target vessels) was significant (p=0.0051). The catheter effect on the number of non-target vessels embolized was significant (p=0.0590). Across all catheter types, the injection method effect was not statistically significant for either of two outcome measures (percent microspheres to target vessels: p=0.2652, number of non-target vessels embolized: p=0.1476). Conclusion: Catheter type had a significant effect on targeting accuracy across all injection methods. The Endobar catheter exhibited a higher targeting accuracy in pairwise comparisons with the other two injection catheters across all injection schemes and when considering the Endobar catheter with the manifold injection method vs. each of the catheters with the manual injection method; the differences were significant in 3 of 4 analyses. The injection method effect was not statistically significant across all catheter types and when considering the Endobar catheter/Endobar manifold combination vs. Endobar catheter injections with manual and pressure-replicated methods.

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Section: Introductionmentioning

confidence: 93%

Gastric Artery Embolization: Studying Effects of Catheter Type and Injection Rate on Bead Distributions within a Benchtop Arterial Model

Jernigan

Osborne

Buckner

2020

Preprint

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“…Limitations of this study include small sample size, lack of consistency in the embolic used, and presence of malignancies in the study cohort. More recent retrospective analyses using the same upper GI bleeding population but specifically excluding patients with cancer have been performed by Anton et al 107 and Kim et al 108 and revealed total weight loss percentages were 11.7 and 17.4% at 4 and 12 months, respectively. Changes in body composition metrics has also been observed following LGA embolization for upper GI bleeding with data showing statistically significant reductions in body weight, BMI, subcutaneous fat index, and skeletal muscle index.…”

Section: Clinical Investigationsmentioning

confidence: 99%

A Review of Past and Present Weight Loss Strategies and the Potential Role of Bariatric Arterial Embolization

Danda

Bailey

Weiss

2020

Digestive Disease Interventions

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The obesity epidemic is a growing public health concern that has a severe effect on the health care system with significant morbidity, mortality, and cost. Treatment options for obesity include lifestyle modifications, pharmacotherapy, and bariatric surgery. Newer, less-invasive therapies including endoscopic bariatric procedures have been developed in recent years to fill the treatment gap that exists between noninvasive approaches and surgery. Bariatric artery embolization (BAE) is a novel minimally invasive endovascular procedure that has been developed to treat obesity. Recent evidence has suggested that bariatric embolization is well tolerated and can induce clinically significant weight loss through a hormonally mediated mechanism. This article will review existing preclinical and clinical data, and explore future directions of the endovascular treatment of obesity.

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“…Previous animal studies have demonstrated a decreased ghrelin production after the procedure. Apparently the procedure is safe, however the data about its efficacy is still awaited (28).…”

Section: Gastric Artery Embolizationmentioning

confidence: 99%

Innovative solutions in bariatric surgery

et al. 2016

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Bariatric Left Gastric Artery Embolization for the Treatment of Obesity: A Review of Gut Hormone Involvement in Energy Homeostasis

Cited by 23 publications

References 52 publications

Gastric Artery Embolization: Studying Effects of Catheter Type and Injection Rate on Bead Distributions within a Benchtop Arterial Model

Gastric Artery Embolization: Studying Effects of Catheter Type and Injection Rate on Bead Distributions within a Benchtop Arterial Model

A Review of Past and Present Weight Loss Strategies and the Potential Role of Bariatric Arterial Embolization

Innovative solutions in bariatric surgery

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