Barbaloin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK

Zhang, Peiyong; Liu, Xiaochen; Huang, Guotao; Bai, Caiyan; Zhang, Zhenling; Li, Hongjun

doi:10.1016/j.bbrc.2017.06.188

Cited by 35 publications

(32 citation statements)

References 27 publications

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“…Meanwhile, ginsenoside Rb2 showed anti‐inflammatory effects by decreasing the activities and mRNA levels of IL‐1β, IL‐6, and TNF‐α. Moreover, the inhibition of myocardial oxidative stress and inflammation response is crucial for the development of cardioprotective strategies against MI/R‐induced injury (Tian et al., 2015; P. Zhang et al., 2017). On the basis of the effects of apoptotic factors Bcl‐2 and caspases on ginsenoside Rb2 treatment, the activity of p53 was further evaluated, which interacted with Bcl‐2 and caspase families, and SIRT1 as a p53 deacetylase was closely related to oxidation and inflammation.…”

Section: Resultsmentioning

confidence: 99%

Ginsenoside Rb2 alleviates myocardial ischemia/reperfusion injury in rats through SIRT1 activation

Xue

Liu

et al. 2020

Journal of Food Science

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The cardioprotective effects of ginsenoside Rb2 on oxidative stress, which is induced by hydrogen peroxide and myocardial ischemia/reperfusion (MI/R) injury, have been studied. The mechanisms were associated with the inhibition of cardiomyocyte apoptosis, a high concentration of antioxidant defense enzymes, and scavenging oxidative stress products. Because of the association with oxidative reaction and cardioprotection, sirtuin‐1 (SIRT1) was selected as a promising target for investigating whether MI/R injury can be alleviated by ginsenoside Rb2 pretreatment through SIRT1 activation. The rats were exposed to ginsenoside Rb2 with or without SIRT1 inhibitor EX527 before ligation of coronary artery. Ginsenoside Rb2 reduced myocardial superoxide generation; downregulated gp91phox expression; and decreased the mRNA expression levels and activities of interleukin‐1β, interleukin‐6, and tumor necrosis factor‐α. The results demonstrated that ginsenoside Rb2 significantly attenuated oxidative stress and inflammation induced by MI/R injury. In addition, ginsenoside Rb2 upregulated SIRT1 expression and downregulated Ac‐p53 expression. However, EX527 blocked the protective effects, indicating that the pharmacological action of ginsenoside Rb2 involves SIRT1. Our results thus revealed that ginsenoside Rb2 alleviated MI/R injury in rats by inhibiting oxidative stress and inflammatory response through SIRT1 activation. Practical Application Ginsenoside Rb2 has a protective effect on MI/R injury by activating SIRT1 expression, reducing myocardium inflammation, and alleviating oxidative stress. Thus, ginsenoside Rb2 is a promising novel agent for ameliorating MI/R injury in ischemic heart diseases and cardiac surgery.

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Section: Resultsmentioning

confidence: 99%

Ginsenoside Rb2 alleviates myocardial ischemia/reperfusion injury in rats through SIRT1 activation

Xue

Liu

et al. 2020

Journal of Food Science

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“…[48] Barbaloin pretreatment has been shown to alleviate myocardial ischemia-reperfusion injury by antioxidant and anti-inflammatory effects. [17] Barbaloin has been reported to have antiviral activity [49] and anti-inflammatory [50] property and may be used as a potential candidate for an alternative for antimicrobial therapy. Barbaloin has been shown to reduce inflammation and ROS formation in alcohol-mediated liver injury.…”

Section: Discussionmentioning

confidence: 99%

Uretral foreign body; Evaluation of an interesting case guided by the literature

Şahin¹

2015

Kartal TR

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The present study aims to examine the protective effects of barbaloin on renal injured by cecal ligation and puncture (CLP) model. Methods: In our study, animals were divided into four groups. Study groups were designed as follows: sham, CLP, DMSO+CLP and 20 mg/kg barbaloin+CLP. Oxidative stress and cytokines were evaluated in renal tissues obtained at the end of the experiment. Results: The findings showed that the TOS, OSI, MPO, MDA, TNF-α and IL-1β increased and TAS and SOD decreased in the CLP group, but in the treatment group, molecule concentrations changed significantly. Conclusion: Our results have demonstrated that of barbaloin is effective against kidney injury caused by CLP-induced polymicrobial sepsis model.

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“…ex Steud. (Luhui), barbaloin, can regulate oxidative stress and inflammation response by activation of AMPK, contributing to cardioprotective functions (Zhang et al, 2017). Resveratrol, a natural phenol generated by Reynoutria japonica Houtt.…”

Section: S: Cmm-derived Small-molecule Compounds/drugs Against Cardiomentioning

confidence: 99%

Clinical Prescription-Protein-Small Molecule-Disease Strategy (CPSD), A New Strategy for Chinese Medicine Development: A Case Study in Cardiovascular Diseases

Guo

Jiang

et al. 2020

Front. Pharmacol.

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Chinese medicine is a national treasure that has been passed down for thousands of years in China. According to the statistics of the World Health Organization, there are currently four billion people in the world who use Chinese medicine to treat diseases, accounting for 80% of the world's total population. However, the obscurity of its theory, its unmanageable quality, its complex compositions, and the unknown effective substances and mechanisms are great obstacles to the internationalization of Chinese medicine. Here, we propose a new strategy for the development of Chinese medicine: the clinical prescription (C)-protein (P)-small-molecule (S)-disease (D) strategy, namely the CPSD strategy. The strategy uses clinical prescriptions as the source of medicine and uses computer simulation technology to find small-molecule drugs targeting therapeutic proteins for treating specific diseases so as to deepen awareness of the value of Chinese medicine. At the same time, this article takes cardiovascular drug development as an example to introduce the application of CPSD, which will be instrumental in the further development, modernization, and internationalization of Chinese medicine.

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Barbaloin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK

Cited by 35 publications

References 27 publications

Ginsenoside Rb2 alleviates myocardial ischemia/reperfusion injury in rats through SIRT1 activation

Ginsenoside Rb2 alleviates myocardial ischemia/reperfusion injury in rats through SIRT1 activation

Uretral foreign body; Evaluation of an interesting case guided by the literature

Clinical Prescription-Protein-Small Molecule-Disease Strategy (CPSD), A New Strategy for Chinese Medicine Development: A Case Study in Cardiovascular Diseases

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