Eupatorium adenophorumspreng is a global invade weed but is also an excellent enrichment plant for heavy metal. However, the characteristics of physiology is still not clear under heavy metals stress. The research focused on changes of plant height, basal diameter, leaf length and width, POD activity, protein content, chlorophyll content, electric conductivity and MDA content in different Pb concentration. The results showed that all indexes were descend in different extent in Pb condition, especially part indexes, such as plant height, soluble and insoluble protein and POD activity, were significant difference with control. But, combined treatment condition (500-2000 mg/kg) with these indexesEupatorium adenophorumspreng showed the better characteristics to as a pioneering plant for ecological restoration of some serious mining wasteland.