Band-shaped and whorled microcystic dystrophy of the corneal epithelium

Lisch Corneal Dystrophy

“…1 No periodic acid-Schiff nor Alcian blue acid mucopolysaccharide staining is present. 3 Electron microscopy reveals intracytoplasmic vacuoles that look optically empty or containing weakly osmophilic, partly homogeneous, and partly lamellar material. 1 The vacuoles tend to coalesce, finally resulting in a structureless transparent cytoplasm.…”

Treatment of Lisch Corneal Dystrophy With Photorefractive Keratectomy and Mitomycin C

“…Reports by Robin et al, 3 Charles et al, 4 Alvarez-Fischer et al, 5 and Lisch et al 6 have described additional cases. Treatment options consisted of topical therapy (lubricants and steroids), epithelial scraping, and contact lenses, with mostly limited success because recurrence is common.…”

High-Resolution Optical Coherence Tomography Findings of Lisch Epithelial Corneal Dystrophy

“…Alcohol-assisted epithelial debridement and contact lens placement have both been successfully attempted, with some degree of recurrence reported 7,9 . Treatment using photorefractive keratectomy (PRK) combined with mitomycin C (MMC) application has also been described with minimal recurrence 3,9 .…”

“…Histopathologic analysis of superficial scrapings from affected corneal epithelium demonstrates sheets of cells with a bubbly cytoplasm and vacuoles made of glycogen, prevalent in the suprabasalar cell layers 1,3–7 . Slit-lamp examination reveals varying shapes of homogenous gray defects often in whorled and fimbriated patterns 1–9 .…”

“…In vivo confocal microscopy has shown well-demarcated regions of uniformly affected cells with hyporeflective nuclei and hyperreflective cytoplasm 3,4,6,9 . Additionally, electron microscopy reveals the vacuoles to contain a laminated and clumped substance or whorled material 3,4,7 .…”