Banana Juice Reduces Bioavailability of Levodopa Preparation

Ogo, Yuki; Sunagane, Nobuyoshi; Ohta, Takafumi; Uruno, Tsutomu

doi:10.1248/yakushi.125.1009

Cited by 8 publications

(7 citation statements)

References 1 publication

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“…This drug-incompatibility might become a significant drug-food interaction because the reaction is rapidly progressive. As in the case of DOPA, MD might also have reduced bioavailability when administered concomitantly with banana juice [8]. The effects of intestinal absorption of MD when administered with banana should be clarified in in vivo experiments or clinical settings.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, there is substantial proof that indicates the alteration of color is caused by polyphenol oxidase (catechol oxidase; EC 1.10.3.1), an enzyme related with melanin biosynthesis, and found in banana pulp [5,6,7]. Furthermore, it was reported that the drug-incompatibility causes a reduction in bioavailability when the mixture is administered orally [8]. DOPA is a biological substrate in animals and plants that is involved in the melanin formation reaction [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Degradation of Methyldopa by Banana

Uesawa

Mohri

2010

Pharmaceuticals

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Methyldopa, an antihypertensive, is a very close analogue of DOPA. Drug interaction accompanied by degradation in a banana juice mixture was reported for DOPA. However, the effect of banana on methyldopa has not been reported. Therefore, we have investigated the impact of banana juice on methyldopa. The drug and supernatant of banana pulp were mixed, and the mixture was observed for changes in color, drug concentration, and ultraviolet-visible absorption spectra at 30 °C. The originally clear and colorless mixture started to acquire a yellow coloration after about 30 seconds after the mixing. The color tone increasingly deepened, then blistered solid particles that do not dissolve were observed after 3 hours. Concentration of methyldopa in the mixture decreased by 60% after 5 min, to 0.5% after 30 min of the mixing. From these findings, it was suggested that the drastic alterations were caused by banana polyphenol oxidase that plays a role in the biosynthesis of melanin pigment from levodopa in banana pulp. Because the degradation of methyldopa occurs extremely fast, it was suggested concomitant use of this anti-hypertensive and banana juice consumption should be avoided in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Degradation of Methyldopa by Banana

Uesawa

Mohri

2010

Pharmaceuticals

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“…Thus, our observations suggest that the incompatibility is due to an enzymatic reaction. Polyphenol oxidase found in bananas causes loss of levodopa potency by impacting levodopa bioavailability [ 2 ]. Previously, we reported that similar to levodopa, the potency of α-methyldopa, a catecholic oral drug, was rapidly diminished by enzymes present in bananas [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, banana pulp contains polyphenol oxidase [ 1 ], which rapidly converts catechols with two phenolic hydroxyl groups in the ortho- position into melanin precursors. Thus, banana components have been shown to interact and attenuate the actions of catecholic medications such as levodopa and reduce drug bioavailability and efficacy [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Bananas decrease acetaminophen potency in in vitro assays

Uesawa

Tsuji²

2018

PLoS ONE

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Edible portions of bananas contain high levels of polyphenol oxidase, which catalyzes reactions in the melanin formation pathway. Tyrosine, a physiological substrate of polyphenol oxidase, has an analogous structure to acetaminophen. We investigated whether banana extract causes structural changes in acetaminophen and a decrease in its potency. Acetaminophen concentration in banana extract was measured under different conditions to characterize incompatibility. Reaction products in solution were identified using liquid chromatography/electrospray ionization/mass spectrometry (LC/ESI/MS). Acetaminophen potency decreased with time in the presence of banana extract. The reaction proceeded most efficiently in temperatures 30–37°C and neutral to weakly acidic conditions. Molecular ion peaks derived from the oxidized catechol moiety of acetaminophen were identified in LC/ESI/MS spectra. Our findings suggest that incorporation or simultaneous administration of acetaminophen medication and banana juice may result in decreased efficacy of the clinically important drug. This interaction is likely due to the oxidation of acetaminophen by polyphenol oxidase activity in banana pulp. Therefore, we investigated and characterized a novel interaction between bananas and acetaminophen. To establish a safe and effective antipyretic analgesic regimen using acetaminophen, future studies of this interaction are expected to be performed in humans.

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“…Interestingly, however, administration of levodopa with a commercial beverage containing 10% banana juice resulted in no significant change in C max . Based on these results, the authors concluded that patients should be advised against mixing levodopa and fresh banana juice (Ogo et al 2005).…”

Section: Dopaminergic Agentsmentioning

confidence: 98%

Role of food-drug interactions in neurological and psychological diseases

Karadağ¹,

Çelik²,

Kadayifçi³

et al. 2018

Acta Neurobiologiae Experimentalis

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Given that foods and nutrients have been shown to influence the pharmacokinetics of drugs, drugs may cause changes in the nutritional status of patients and their response to a given drug. Food-drug interactions are particularly relevant for drugs used to treat neurological and psychological diseases. This review provides an overview of food-drug interaction in the treatment of neurological and psychological diseases. A literature search was carried out by collecting data from different reviews, reports, and original articles on general or specific drug interactions with food, in patients with a variety of neurological and psychological diseases. Based on our review, we found that food-drug interactions may alter the expected impact of drug, or cause the development of a drug toxicity. Nutritional status of the patients may also be affected, particularly a change in body weight caused by a change appetite. Metabolism, absorption, and excretion of foods may also be altered, and nutritional insufficiencies may occur. Recent studies show that diet can have a strong influence on gut microbiota and thus, alter drug pharmacokinetics.Therefore, microbiota alterations should also be considered while assessing food-drug interactions. Knowledge of food-drug interactions is critical for improving health of patients with neurological and psychological diseases, and also for improving effectiveness of treatments.

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Banana Juice Reduces Bioavailability of Levodopa Preparation

Cited by 8 publications

References 1 publication

Degradation of Methyldopa by Banana

Degradation of Methyldopa by Banana

Bananas decrease acetaminophen potency in in vitro assays

Role of food-drug interactions in neurological and psychological diseases

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