Baldwin, J. M.

Preliminary observations of a new approach to tissue repair: Peripheral blood mononuclear cells in platelet‐rich plasma injected into skin graft area

“…Platelet growth factors (GFs) of alpha and dense granules and antiinflammatory mediators in platelet-rich plasma (PRP) are biologically active peptides that enhance tissue repair mechanisms (as angiogenesis, extracellular matrix remodelling), and cooperate in cellular effects, as stem cells recruitment, chemotaxis, cell proliferation and differentiation. [1][2][3] The contribution of PRP in promoting tissue healing can be combined with cell-based therapies such as adiposederived stem cells or regenerative cell therapy. [1] Peripheral blood mononuclear cells (PB-MNCs), in particular the monocyte lineage, may play a role in the epithelialisation, granulation tissue formation and neovascularisation; this producing different cytokines within their cell secretome, [4] by cellular differentiation developing an epithelial-like profile, [5] and through the dynamic changes of macrophages during different phases of wound healing.…”

“…[1][2][3] The contribution of PRP in promoting tissue healing can be combined with cell-based therapies such as adiposederived stem cells or regenerative cell therapy. [1] Peripheral blood mononuclear cells (PB-MNCs), in particular the monocyte lineage, may play a role in the epithelialisation, granulation tissue formation and neovascularisation; this producing different cytokines within their cell secretome, [4] by cellular differentiation developing an epithelial-like profile, [5] and through the dynamic changes of macrophages during different phases of wound healing. [6] The co-culture of PB-MNCs with platelet gel suggests the capacity of influence the whole process of tissue regeneration.…”