1991
DOI: 10.1128/mcb.11.6.3148
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BALB/c-3T3 fibroblasts resistant to growth inhibition by beta interferon exhibit aberrant platelet-derived growth factor, epidermal growth factor, and fibroblast growth factor signal transduction.

Abstract: Several lines of evidence now exist to suggest an interaction between the platelet-derived growth factor (PDGF) growth-stimulatory signal transduction pathway and the beta interferon (IFN-j8) growth-inhibitory signal transduction pathway. The most direct examples are inhibition of PDGF-mediated gene induction and mitogenesis by IFN-4 and the effects of activators and inhibitors of the IFN-inducible double-stranded RNAdependent eIF2 kinase on expression of PDGF-inducible genes. To further investigate the nature… Show more

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Cited by 16 publications
(4 citation statements)
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“…Although very little is known about the signaling mechanisms of the various inhibitory factors, some other data support the concept of multiple inhibitory pathways. For example, increasing evidence suggests that IFN-y may interfere directly with growth stimulatory mechanisms induced by growth factors, including FGF (Friesel et al, 1987;Hosang, 1988;Mundschau and Faller, 1991), in contrast to TGF,31, which does not appear to inhibit growth factor-induced events (see Sporn and Roberts, 1990).…”
Section: Discussionmentioning
confidence: 97%
“…Although very little is known about the signaling mechanisms of the various inhibitory factors, some other data support the concept of multiple inhibitory pathways. For example, increasing evidence suggests that IFN-y may interfere directly with growth stimulatory mechanisms induced by growth factors, including FGF (Friesel et al, 1987;Hosang, 1988;Mundschau and Faller, 1991), in contrast to TGF,31, which does not appear to inhibit growth factor-induced events (see Sporn and Roberts, 1990).…”
Section: Discussionmentioning
confidence: 97%
“…The phosphorylation of eIF2a is not necessarily restricted to stressful or pathological circumstances since it is becoming apparent that it may well also be involved in the normal regulation of cell growth (Mundschau and Faller 1991;Chong et al 1992). Changes in the phosphorylation state of eIF2a, or in the activities of the relevant pro tein kinases, can occur when cell proliferation is stimulated by mitogens and growth factors (Montine and Henshaw 1989;Ito et al 1994), when mitogenic signalling is inhibited by fiavonoids such as genistein (Ito et al 1999a), or when cell differentiation is induced in several systems (Petryshyn et al 1984(Petryshyn et al , 1988Kronfeld-Kinar et al 1999).…”
Section: Physiological Regulation Of Elf2a Phosphorylationmentioning
confidence: 99%
“…,3IFN appears to inhibit growth stimulatory signaling pathways directly (14), and appears to be involved in the natural suppression of immune proliferation in response to stimuli ( 15). ( 17).…”
Section: Discussionmentioning
confidence: 99%