Inhibition of human erythroid colony-forming units by tumor necrosis factor requires beta interferon.

Means, Robert T.; Krantz, Sanford B.

doi:10.1172/jci116216

Cited by 136 publications

(78 citation statements)

References 17 publications

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“…Subsequent in vitro studies, however, showed that the inhibitory effect of TNF-a on erythropoiesis at the CFU-E level was likely mediated by IFN-b released by macrophages in response to TNF-a and not due to a direct effect of TNF-a on erythroid progenitors. 67,68 However, in another study, a direct effect of TNF-a on erythroid progenitors (BFU-E) was suggested, mediated by the TNF-R1. 69 A direct effect of TNF-a on erythroid cells was supported by subsequent studies.…”

Section: Role Of Cell Death Receptors In the Control Of Erythropoiesismentioning

confidence: 96%

Apoptotic mechanisms in the control of erythropoiesis

2004

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Erythropoiesis is a complex multistep process encompassing the differentiation of hemopoietic stem cells to mature erythrocytes. The steps involved in this complex differentiation process are numerous and involve first the differentiation to early erythoid progenitors (burst-forming units-erythroid, BFU-E), then to late erythroid progenitors (colony-forming unitserythroid) and finally to morphologically recognizable erythroid precursors. A key event of late stages of erythropoiesis is nuclear condensation, followed by extrusion of the nucleus to produce enucleated reticulocytes and finally mature erythrocytes. During the differentiation process, the cells became progressively sensitive to erythropoietin that controls both the survival and proliferation of erythroid cells.A normal homeostasis of the erythropoietic system requires an appropriate balance between the rate of erythroid cell production and red blood cell destruction. Growing evidences outlined in the present review indicate that apoptotic mechanism play a relevant role in the control of erythropoiesis under physiologic and pathologic conditions. Withdrawal of erythropoietin or stimulation of death receptors such as Fas or TRAIL-Rs leads to activation of a subset of caspases-3, -7 and -8, which then cleave the transcription factors GATA-1 and TAL-1 and trigger apoptosis. In addition, there is evidence that a number of caspases are physiologically activated during erythroid differentiation and are functionally required for erythroid maturation. Several caspase substrates are cleaved in differentiating cells, including the protein acinus whose activation by cleavage is required for chromatin condensation.The studies on normal erythropoiesis have clearly indicated that immature erythroid precursors are sensitive to apoptotic triggering mediated by activation of the intrinsic and extrinsic apoptotic pathways. These apoptotic mechanisms are frequently exacerbated in some pathologic conditions, associated with the development of anemia (ie, thalassemias, multiple myeloma, myelodysplasia, aplastic anemia).The considerable progress in our understanding of the apoptotic mechanisms underlying normal and pathologic erythropoiesis may offer the way to improve the treatment of several pathologic conditions associated with the development of anemia.

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Section: Role Of Cell Death Receptors In the Control Of Erythropoiesismentioning

confidence: 96%

Apoptotic mechanisms in the control of erythropoiesis

2004

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“…28 TNF-␣ has been shown to inhibit erythropoiesis, [29][30][31] although it has been demonstrated that the inhibitory effects of TNF-␣ were likely mediated by ␤-interferon produced by macrophages in response to TNF-␣ and not due to direct actions of TNF-␣. 32,33 TNF-␣ also has been reported to promote proliferation of CD34 ϩ human hematopoietic cells. 34 The direct action of TNF-␣ on erythroid cells therefore remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Tumor necrosis factor-alpha expressed constitutively in erythroid cells or induced by erythropoietin has negative and stimulatory roles in normal erythropoiesis and erythroleukemia

Jacobs-Helber

Roh

Bailey

et al. 2003

Blood

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“…Erythropoetin levels below those expected for the degree of anemia have been demonstrated in septic and critically ill patients [69,70]. There is evidence that inflammatory cytokines have play an inhibitory role on erythropoietin production as well as a direct inhibitory effect on erythroid progenitor cell production in the bone marrow [71][72][73][74][75].…”

Section: Erythropoesismentioning

confidence: 99%

Red Blood Cell Transfusion in Sepsis: A Review

Sadaka¹

2013

J Blood Disord Transfus

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Sepsis is very common and lethal. Sepsis is the leading cause of death in non-coronary Intensive Care Units, and the tenth leading cause of death overall. Red blood cell transfusion is one of the most commonly used interventions in the ICU to treat severe anemia, which often occurs in sepsis. Several problems were documented with RBC transfusions and will be reviewed, such as infection, pulmonary complications such as TRALI and Transfusion-Associated Circulatory Overload (TACO), Transfusion-Related Immunomodulation (TRIM) and multiorgan failure, and increased mortality. Most of these complications are partially explained by volume of the unit of blood as well as pathogenic factors of stored RBCs related to 2,3 BPG concentration, inflammatory mediators, nitric oxide, ATP concentration and RBC rheology, and RBC adhesion characteristics. These same factors are present in RBCs of septic patients as well. Until better evidence is available, a "restrictive" strategy of RBC transfusion (transfuse when Hb < 7 g/dL) is recommended except in acute hemorrhage, or in patients with acute myocardial ischemia when a hemoglobin trigger of 8 g/dl is reasonable.

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Inhibition of human erythroid colony-forming units by tumor necrosis factor requires beta interferon.

Cited by 136 publications

References 17 publications

Apoptotic mechanisms in the control of erythropoiesis

Apoptotic mechanisms in the control of erythropoiesis

Tumor necrosis factor-alpha expressed constitutively in erythroid cells or induced by erythropoietin has negative and stimulatory roles in normal erythropoiesis and erythroleukemia

Red Blood Cell Transfusion in Sepsis: A Review

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