Balanitis due to fixed drug eruption associated with tetracycline therapy.

Csonka, G. W.; Rosedale, N.; Walkden, L

doi:10.1136/sti.47.1.42

Cited by 13 publications

(10 citation statements)

References 8 publications

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“…Tetracyclines were responsible for producing lesions exclusively over the glans penis (p<O.OOI), as highlighted by several other workers (9,12,15). Though used as frequently in females, tetracyclines peculiarly spares female genitalia (20).…”

Section: Discussionmentioning

confidence: 94%

“…The lesions of FDE can occur on any part of the skin or mucous membranes, including mucocutaneous junctions (1,8). However, the sites of predilection include the lip, sacral region and genitalia (9,10). Although the sites of primary lesion(s) cannot be predicted, local injury or trauma have been implicated in localisation of FDE (Koebner-like phenomenon) (11).…”

Section: Introductionmentioning

confidence: 99%

“…The nature of the drug(s) incriminated appears to be the other important determining factor for involvement of specific sites. Tetracycline induced FDE is known to localize over the glans penis exclusively (9,12); FDE due to dapsone conspicuously spares the glans penis (8).…”

Section: Introductionmentioning

confidence: 99%

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Drug Related Involvement of Specific Sites in Fixed Eruptions: A Statistical Evaluation

Sharma

Dhar

Gill

1996

The Journal of Dermatology

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Different drugs produce fixed eruptions over different parts of the body. However, the significance of preferential site involvement in fixed eruptions due to specific drugs has not been statistically evaluated. One hundred and twenty five patients of fixed drug eruption (FDE) were studied to examine this question. Different sites affected by individual drugs were classified as lips alone, genitalia alone, lips and genitalia together, trunk alone, trunk and limbs together, and generalized. Statistical analysis was carried out for 7 common drugs causing FDE in 5 or more patients. Cotrimoxazole, a combination of sulfamethoxazole and trimethoprim, was the most common offender for FDE (32.8%), followed by analgin (12%), tetracycline (8%), pyrazolones (8%), metronidazole (6.4%), ciprofloxacin (5.6%), and phenytoin sodium (4%). Major sites involved by FDE were trunk and limbs (24%), lips alone (20.8%), genitalia alone (20%), generalised (14.4%), lips and genitalia together (11.2%), and trunk alone (8.8%). Seventy-two (57.6%) patients had multiple lesions; 33 (42.4%) had single lesions. Involvement of mucocutaneous junctions of lips and genitalia by FDE was frequently caused by cotrimoxazole and tetracycline; trunk and limbs, by analgin and pyrazolones. Generalised eruptions were commonly caused by cotrimoxazole and phenytoin. The present statistical analysis confirms the clinical impression that genitalia alone are frequently involved in FDE due to tetracyclines (p < 0.001). FDE over trunk and limbs was significantly associated with analgin (p < 0.001), and generalised eruptions, with phenytoin sodium (p < 0.001). The association of FDE over lips with cotrimoxazole was statistically not significant.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Drug Related Involvement of Specific Sites in Fixed Eruptions: A Statistical Evaluation

Sharma

Dhar

Gill

1996

The Journal of Dermatology

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“…Others, however, are more or less distinctive and character¬ istic of specific agents such as bleomycin-induced linear hyperpigmentation1 or the fungating nodules seen in iododerma or bromoderma. 23 Fixed drug eruption (FDE), in particular, has its own character¬ istics and may be associated with the ingestion of a number of agents. The incidence of FDE induced by a specific drug depends on the frequency of the agent used in a given part of the world.…”

Section: Drugmentioning

confidence: 99%

Fixed drug eruption. A brief review

Korkij¹

1984

Archives of Dermatology

112

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“…Five cases of balanitis due to fixed eruption after tetracycline therapy were reported by Csonka, Rosedale, and Walkden (1971) and since then a severe recurrent balanitic reaction has been observed in one patient after taking single doses of 'Mandrax' (diphenhydramine-methaqualone). No similar case appears to have been published.…”

mentioning

confidence: 99%