Balance of Fatty Acids and Their Correlations with Parameters of Lipid Metabolism and Markers of Inflammation in Men with Coronary Atherosclerosis

Polonskaya, Yа. V.; Шрамко, В.; Морозов, С. В.; Chernyak, E. I.; Chernyavsky, Alexander; Ragino, Y.

doi:10.1007/s10517-017-3920-x

Cited by 9 publications

(6 citation statements)

References 5 publications

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“…The results suggest that lipid metabolites play an essential role in the pathogenesis of AS. Previous serum metabolomic studies showed that patients with coronary heart disease metabolize lipids, especially phospholipids, very differently to healthy people (23)(24)(25), which is consistent with our research results.…”

Section: Discussionsupporting

confidence: 93%

Non-targeted metabonomic analysis of plasma in patients with atherosclerosis by liquid chromatography-mass spectrometry

Xia¹,

Li²,

Xie³

et al. 2022

Ann Transl Med

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Background: This study sought to analyze non-targeted plasma metabolites in patients with atherosclerosis (AS). Methods:The plasma of patients with AS (the patient group) and the plasma of age-matched and gendermatched healthy individuals (the control group) at the Taihe Hospital was collected. One hundred patients were included in the study (60 in the patient group and 40 in the control group). Fasting venous plasma was collected in the morning. The metabolites in the plasma were examined by liquid chromatographymass spectrometry (LC-MS). An unsupervised principal component analysis (PCA) was conducted to observe the overall distribution of each sample and the stability of the analysis process. Next, a supervised partial least squares-discriminant analysis (PLS-DA) and an orthogonal partial least squares-discriminant analysis (OPLS-DA) were conducted to examine the overall differences among the metabolic profiles of the groups and identify different metabolites in the groups. Pathway enrichment was analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database.Results: In total, 1,126 different metabolites were detected in the patient and control groups. Compared to the control group, 411 species decreased, and 715 species increased in the patient group. There were 61 different metabolites with a variable weight in the projection (VIP) >1 and a P<0.05. There were 34 types of lipid metabolites, 10 types of carbon and oxygen compounds, 8 types of organic acids and derivatives, 4 types of organoheterocyclic compounds, 3 types of nitrogen-containing organic compounds, and 2 types of nucleotides and analogs. Compared to the control group, 47 species decreased, and 14 species increased in the patient group. The following 9 metabolites had the most significant differences (|log2fold change| >1; P<0.05): 2-tetradecanone, pantothenol, all-trans-13,14-dihydroretinol, linoleoyl ethanolamide, N-oleoylethanolamine, 4-methyl-2-pentenal, Cer (d18:1/14:0), chenodeoxycholic acid glycine conjugate, and 5-acetamidovalerate. The enrichment analysis results of the 61 different metabolite pathways identified 17 metabolic pathways with significant differences (P<0.05), including the choline metabolism, lipid metabolism, autophagy, amino acid metabolism, vitamin digestion, and absorption pathways.Conclusions: There are significant differences in non-targeted plasma metabolites between patients with AS and healthy individuals. The above-mentioned 9 most significantly different metabolites may be potential markers of AS.

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Section: Discussionsupporting

confidence: 93%

Non-targeted metabonomic analysis of plasma in patients with atherosclerosis by liquid chromatography-mass spectrometry

Xia¹,

Li²,

Xie³

et al. 2022

Ann Transl Med

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“…75 Furthermore, lipid metabolism disturbances in coronary atherosclerosis were accompanied by changes not only in lipid spectrum but also increased concentrations of saturated fatty acids, CRP and interleukins: IL-6, IL-8. 76 Additionally, in a large cohort of European adults, the oddchain saturated fatty acids was inversely associated with CRP and Castelli index. In contrast, there were positive associations between the even-chain saturated fatty acids and CRP and lipids: triglycerides, low density lipoproteincholesterol, Castelli index and inverse associations with high density lipoprotein-cholesterol.…”

Section: Triglycerides and High Density Lipoproteins-cholesterolmentioning

confidence: 97%

Metabolic Syndrome in an Aging Society – Role of Oxidant-Antioxidant Imbalance and Inflammation Markers in Disentangling Atherosclerosis

Dzięgielewska-Gęsiak¹

2021

CIA

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Introduction:The prevalence of metabolic syndrome among the elderly population is growing. The elements of metabolic syndrome in an aging society are currently being researched. Atherosclerosis is a slow process in which the first symptoms may be observed after many years. The mechanisms underlying the progression of atherosclerosis are oxidative stress and inflammation. Inflammation and oxidative stress are associated with the increased incidence of metabolic syndrome. Taking the above into consideration, metabolic syndrome is thought to be a clinical equivalent of atherosclerosis. Aim: The aim of this paper is to review the impact of the interplay of oxidant-antioxidant and inflammation markers in metabolic syndrome in general as well as its components in the pathophysiology which underlies development of atherosclerosis in elderly individuals. Methods: A systematic scan of online resources designed for elderly (≥65 years) published from 2005 to the end of 2020 were reviewed. This was supplemented with grey literature and then all resources were narratively analyzed. The analysis included the following terms: "atherosclerosis or metabolic syndrome" and "oxidative stress or inflammation" and "elderly" to find reports of atherosclerotic disease from asymptomatic to life-threatening among the elderly population with metabolic syndrome . Results: The work summarizes articles that were applicable to this study, including systematic reviews, qualitative studies and opinion pieces. Current knowledge focuses on monitoring the inflammation and oxidant-antioxidant imbalance in disentangling atherosclerosis in patients diagnosed with metabolic syndrome. The population-based studies described inflammation, increased oxidative stress and weak antioxidant defense systems as the mechanisms underlying atherosclerosis development. Moreover, there are discussions that these targets could potentially be a point of intervention to reduce the development of atherosclerosis in the elderly, especially those with altered glucose and lipid metabolism. Specific markers may be used as an approach for the prevention and lifestyle modification of atherosclerotic disease in such population. Conclusion: Metabolic syndrome and its components are important contributors in the progression of atherosclerotic disease in the elderly population but constant efforts should be made to broaden our knowledge of elderly groups who are the most susceptible for the development of atherosclerosis complications.

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“…FAs are essentially the functional components of triglycerides and as such, the development and progression of atherosclerosis is tied to the various FAs present in the circulation. The effect of different FAs on the risk of atherosclerotic CVD ranges from pro-atherosclerotic to anti-atherosclerotic depending on the FA [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] . In this Review, we do not provide evidence to close the debate about the role of triglycerides in CVD but instead aim to uncover and clarify the role of FAs in CVD, which might help in the development of future approaches for the treatment and prevention of atherosclerotic CVD.…”

Section: T H 2 Cellsmentioning

confidence: 99%

Effects of fatty acids on T cell function: role in atherosclerosis

et al. 2021

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T cells are among the most common cell types present in atherosclerotic plaques and are increasingly being recognized as a central mediator in atherosclerosis development and progression. At the same time, triglycerides and fatty acids have re-emerged as crucial risk factors for atherosclerosis. Triglycerides and fatty acids are important components of the milieu to which the T cell is exposed from the circulation to the plaque, and increasing evidence shows that fatty acids influence T cell function. In this Review, we discuss the effects of fatty acids on four components of the T cell response -metabolism, activation, proliferation and polarizationand the influence of these changes on the pathogenesis of atherosclerosis. We also discuss how quiescent T cells can undergo a type of metabolic reprogramming induced by exposure to fatty acids in the circulation that influences the subsequent functions of T cells after activation, such as in atherosclerotic plaques.

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Balance of Fatty Acids and Their Correlations with Parameters of Lipid Metabolism and Markers of Inflammation in Men with Coronary Atherosclerosis

Cited by 9 publications

References 5 publications

Non-targeted metabonomic analysis of plasma in patients with atherosclerosis by liquid chromatography-mass spectrometry

Non-targeted metabonomic analysis of plasma in patients with atherosclerosis by liquid chromatography-mass spectrometry

Metabolic Syndrome in an Aging Society – Role of Oxidant-Antioxidant Imbalance and Inflammation Markers in Disentangling Atherosclerosis

Effects of fatty acids on T cell function: role in atherosclerosis

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