Effects of fatty acids on T cell function: role in atherosclerosis

Reilly, Nathalie A.; Lutgens, Esther; Kuiper, Johan; Heijmans, Bastiaan T.; Jukema, J. Wouter

doi:10.1038/s41569-021-00582-9

Cited by 31 publications

(33 citation statements)

References 155 publications

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“…During the process of proliferation, differentiation, and activation of immune cells, the requirement for glucose might differ. Studies have found that inhibition of glycolysis restrains the differentiation of CD4 + T cells to Treg cells and promotes the differentiation of activated CD8 + T cells to long-lived memory CD8 + T cells [119,149] . Accordingly, we presume that timing and personalized diet should be taken into account when applying glucose restriction to supplement ICI treatment.…”

Section: Prospective Strategies For Overcoming Resistance To Icismentioning

confidence: 99%

Resistance to immune checkpoint inhibitors in KRAS-mutant non-small cell lung cancer

Li¹,

Hu²,

Peng³

et al. 2022

CDR

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Non-small cell lung cancer (NSCLC) patients with Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation are associated with significant clinical heterogeneity and a poor prognosis to standard NSCLC therapies such as surgical resection, radiotherapy, chemotherapies, and targeted medicines. However, the application of immune checkpoints inhibitors (ICIs) has dramatically altered the therapeutic pattern of NSCLC management. Clinical studies have indicated that some KRAS-mutant NSCLC patients could benefit from ICIs; however, the responses in some patients are still poor. This review intends to elucidate the mechanisms of resistance to immunotherapy in KRAS-driven NSCLC and highlight the TME functions altered by immunoinhibitors, immunostimulators, and cancer metabolism. These metabolic pathways could potentially be promising approaches to overcome immunotherapy resistance.

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Section: Prospective Strategies For Overcoming Resistance To Icismentioning

confidence: 99%

Resistance to immune checkpoint inhibitors in KRAS-mutant non-small cell lung cancer

Li¹,

Hu²,

Peng³

et al. 2022

CDR

View full text Add to dashboard Cite

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“…Indeed, TG levels did not associate either with COVID-19 infection [36] or with the risk of testing positive for SARS-CoV-2 infection [37]. Finally, it is worth mentioning that fatty acid can generally influence T cell activation, proliferation, and polarization [38,39].…”

Section: Discussionmentioning

confidence: 98%

HDL in COVID-19 Patients: Evidence from an Italian Cross-Sectional Study

Papotti

Macchi

Favero

et al. 2021

JCM

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A number of studies have highlighted important alterations of the lipid profile in COVID-19 patients. Besides the well-known atheroprotective function, HDL displays anti-inflammatory, anti-oxidative, and anti-infectious properties. The aim of this retrospective study was to assess the HDL anti-inflammatory and antioxidant features, by evaluation of HDL-associated Serum amyloid A (SAA) enrichment and HDL-paraoxonase 1 (PON-1) activity, in a cohort of COVID-19 patients hospitalized at the Cardiorespiratory COVID-19 Unit of Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan. COVID-19 patients reached very low levels of HDL-c (mean ± SD: 27.1 ± 9.7 mg/dL) with a marked rise in TG (mean ± SD: 165.9 ± 62.5 mg/dL). Compared to matched-controls, SAA levels were significantly raised in COVID-19 patients at admission. There were no significant differences in the SAA amount between 83 alive and 22 dead patients for all-cause in-hospital mortality. Similar findings were reached in the case of PON-1 activity, with no differences between alive and dead patients for all-cause in-hospital mortality. In conclusion, although not related to the prediction of in-hospital mortality, reduction in HDL-c and the enrichment of SAA in HDL are a mirror of SARS-CoV-2 positivity even at the very early stages of the infection.

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“…T cells, dendritic cells and macrophages, in addition to oxidized LDL, are main components of atherosclerotic plaques [ 26 ]. In two studies, Frostegards et al demonstrated that miR-let7c expression was increased in atherosclerotic plaque induced by increases in oxidized LDL, an effect that can be abolished by statins [ 27 ] and to a lesser degree by PSCK9 inhibition [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Circulating miR-145-5p and miR-let7c and Atherosclerotic Plaques in Hypertensive Patients

et al. 2021

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Aim: Hypertension is a strong risk factor for atherosclerosis. Increased carotid intima-media thickness (cIMT) and carotid plaques are considered subclinical markers of atherosclerosis. This study aimed at evaluating the serum expression of miRNAs previously related to adverse vascular remodeling and correlating them with carotid plaques and cIMT in hypertensive patients. Methods: We cross-sectionally evaluated the clinical and carotid characteristics as well as serum expression of miR-145-5p, miR-let7c, miR-92a, miR-30a and miR-451 in 177 hypertensive patients. Carotid plaques and cIMT were evaluated by ultrasound, and the expression of selected miRNAs was evaluated by a quantitative polymerase chain reaction. Results: Among all participants (age = 60.6 ± 10.7 years, 43% males), there were 59% with carotid plaques. We observed an increased expression of miR-145-5p (Fold Change = 2.0, p = 0.035) and miR-let7c (Fold Change = 3.8, p = 0.045) in participants with atherosclerotic plaque when compared to those without plaque. In the logistic regression analysis adjusted for relevant covariates, these miRNAs showed a stronger association with carotid plaques (miR-145-5p: Beta ± SE = 0.050 ± 0.020, p = 0.016 and miR-let7c: Beta ± SE = 0.056 ± 0.019, p = 0.003). Conclusions: Hypertensive patients with carotid plaques have an increased expression of miR-145-5p and miR-let7c, suggesting a potential role of these miRNAs as a biomarker for subclinical atherosclerosis in hypertensive individuals.

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Effects of fatty acids on T cell function: role in atherosclerosis

Cited by 31 publications

References 155 publications

Resistance to immune checkpoint inhibitors in KRAS-mutant non-small cell lung cancer

Resistance to immune checkpoint inhibitors in KRAS-mutant non-small cell lung cancer

HDL in COVID-19 Patients: Evidence from an Italian Cross-Sectional Study

Association of Circulating miR-145-5p and miR-let7c and Atherosclerotic Plaques in Hypertensive Patients

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