Balance of Activity of Sympathetic, Parasympathetic, and Serotoninergic Divisions of the Autonomic Nervous System in Rabbits

Abstract

We studied the balance of activity of sympathetic, parasympathetic, and serotoninergic divisions of the autonomic nervous system in the regulation of the heart function in rabbits. High activities of the sympathetic and parasympathetic system are associated with antagonistic interactions between them. Moderation of activity of these systems could be accompanied by activation of the serotoninergic system. Physiological sympathectomy and parasympathectomy lead to hyperfunction of the serotoninergic system and pathology.

Effect of serotonin on gonadal function

“…The follicle was ruptured under the effect of LH, because of activation of its production by the pituitary. Our previous studies [2] showed that stimulation of the sympathetic trunk in parallel with stimulation of the vagus nerve led to activation of preganglionic serotoninergic fibers, through which stimulation was transferred to the ganglionic serotoninergic neurons, activating serotonin receptors of effector tissues (heart, stomach, duodenum, gallbladder and Oddi's sphincter, large intestine, urinary bladder and ureters, uterus and uterine tubes). The serotoninergic system is activated after single simultaneous stimulation of the sympathetic and parasympathetic nerves and persists during periodically repeated (for 15-17 h) parallel stimulation of the nerves, which leads to the development of the hyperserotoninergic syndrome.…”