Serotonin regulates contractile activity of the uterus in non-pregnant rabbits

Lychkova, A. E.; Pasquale, Valeria De; Avallone, Luigi; Пузиков, А. М.; Pavone, Luigi Michele

doi:10.1016/j.cbpc.2014.05.006

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…Indeed, pregnant women's psychophysiological activity has been associated with birth, infant, and parenting outcomes (Ablow et al., 2013; Braeken et al., 2017; Entringer et al., 2010), and there are well‐established associations between RSA and markers of cardiovascular health (e.g., obesity, diabetes, hypertension; Masi et al., 2007), which also could influence birth outcomes (e.g., Cnattingius et al., 2013). Furthermore, there may be influences of pregnant women's RSA on the fetal environment, such as through uterine activity and placental blood flow, although these associations warrant further study (Lychkova et al., 2014; Mielke & Benda, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…This study aligns with literature linking childhood maltreatment history with low resting RSA and underscores the importance of studying these relations among pregnant women. Moreover, in addition to facilitating communication between the brainstem and heart, the vagus nerve has been theorized to directly influence uterine activity during pregnancy, such as by modulating contractions during labor and delivery (Lychkova et al., 2014). In addition, it may indirectly influence placental blood flow through cardiovascular influences (Brauer & Smith, 2015; Gnanamanickam & Llewellyn‐Smith, 2011; Mielke & Benda, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Influences of adversity across the lifespan on respiratory sinus arrhythmia during pregnancy

Kaliush

Terrell

Vlisides‐Henry

et al. 2021

Developmental Psychobiology

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There is limited understanding of factors across the lifespan that influence pregnant women's respiratory sinus arrhythmia (RSA), which could have implications for their health and offspring development. We examined associations among 162 English‐ and Spanish‐speaking pregnant women's childhood maltreatment history, emotion dysregulation, recent life stress, and resting RSA during the third trimester. Moderated mediation analyses indicated that more severe childhood maltreatment history (95% confidence interval (CI) [0.26, 0.63]) and higher emotion dysregulation (95% CI [0.001, 0.006]) predicted more stress during pregnancy, and childhood maltreatment history interacted with emotion dysregulation to predict resting RSA (95% CI [−0.04, −0.0003]). Exploratory analyses revealed that women's health‐related stress during pregnancy mediated the relation between emotion dysregulation and RSA regardless of childhood maltreatment severity (95% CI [−0.007, −0.002]). These findings suggest that women's resting RSA during pregnancy may reflect physical and emotional stress accumulation across the lifespan and that relations between early life adversity and prenatal psychophysiology may be buffered by protective factors, such as emotion regulation. In addition, these findings underscore the importance of distinguishing between types of prenatal stress. Given the implications for women's health and offspring development, we urge researchers to continue exploring factors associated with pregnant women's psychophysiology.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influences of adversity across the lifespan on respiratory sinus arrhythmia during pregnancy

Kaliush

Terrell

Vlisides‐Henry

et al. 2021

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…The latter type, which is mainly stored in dense granules of platelets after being released from intestinal enterochromaffin cells, accounts for approximately 95% of serotonin. Previous studies have shown that peripheral serotonin participates in platelet aggregation, gastrointestinal peristalsis, oxidative stress injury, inflammation and immune response, and so forth [15][16][17][18][19][20][21]. In addition, peripheral serotonin may be involved in the progress of several liver diseases such as liver regeneration, viral hepatitis, nonalcoholic steatohepatitis, hepatic fibrosis, and hepatocellular carcinoma via binding to 5-HT 2A and 2B receptors in liver tissue [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

The Role of Serotonin in Concanavalin A-Induced Liver Injury in Mice

Pang

Jin

et al. 2020

Oxidative Medicine and Cellular Longevity

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Serotonin is involved in the pathological processes of several liver diseases via the regulation of inflammatory response and oxidative stress. We aimed to investigate the role of serotonin in Concanavalin A- (Con A-) induced acute liver injury (ALI). ALI was induced in C57B/6 wild-type (WT) mice and tryptophan hydroxylase 1 (TPH1) knockout mice through tail vein injection of Con A (15 mg/kg body weight). Another group of TPH1 knockout ALI mice was supplied with 5-hydroxytryptophan (5-HTP) in advance to recover serotonin. The blood and liver tissues of mice were collected in all groups. Markedly increased serum levels of serotonin were identified after the injection of Con A. Increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and stronger hepatic tissue pathology were detected, suggesting that serotonin could mediate Con A-induced liver damage. Serotonin significantly facilitated the release of serum and intrahepatic inflammatory cytokines, including interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-17A (IL-17A), interferon-gamma (IFN-γ), and tumor necrosis-alpha (TNF-α), after the administration of Con A. In addition, serotonin significantly increased the intrahepatic levels of oxidative stress markers malonaldehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) and decreased antioxidant stress indicator glutathione (GSH) in Con A-treated mice. Additionally, serotonin promoted hepatocyte apoptosis and autophagy based on B-cell lymphoma-2 (Bcl-2), Bcl-2-asociated X protein (Bax), and Beclin-1 levels and TUNEL staining. More importantly, serotonin activated nuclear factor kappa B (NF-κB) and upregulated the hepatic expressions of high mobility group protein B1 (HMGB1), toll-like receptor-4 (TLR4), and downstream molecules in Con A-mediated liver injury. Serotonin 2A receptor was upregulated in liver tissue after Con A injection, and serotonin 2A receptor antagonist Ketanserin protected against Con A-induced hepatitis. These results indicated that serotonin has the potential to aggravate Con A-induced ALI via the promotion of inflammatory response, oxidative stress injury, and hepatocyte apoptosis and the activation of hepatic HMGB1-TLR signaling pathway and serotonin 2A receptor.

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Is vagal-nerve stimulation safe during pregnancy? A mini review

Ding

Wang

et al. 2021

Epilepsy Research

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Serotonin regulates contractile activity of the uterus in non-pregnant rabbits

Cited by 6 publications

References 32 publications

Influences of adversity across the lifespan on respiratory sinus arrhythmia during pregnancy

Influences of adversity across the lifespan on respiratory sinus arrhythmia during pregnancy

The Role of Serotonin in Concanavalin A-Induced Liver Injury in Mice

Is vagal-nerve stimulation safe during pregnancy? A mini review

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