Baitouweng Tang ameliorates DSS-induced ulcerative colitis through the regulation of the gut microbiota and bile acids via pathways involving FXR and TGR5

Hua, Yuejin; Jia, Ya‐qian; Zhang, Xiaosong; Yuan, Ziwen; Ji, Peng; Hu, Junjie; Wei, Yanming

doi:10.1016/j.biopha.2021.111320

Cited by 51 publications

(30 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the genus level, compared with the control group, the number of Lachnospiraceae_ Clostridium, Bilophila , and Halomonas were reduced in the model group, whereas the number of Bacteroides, Parabacteroides , and Paraprevotella were increased; however, nuciferine administration reversed this trend. This is in agreement with results obtained by Hua et al ( 55 ). In addition, PCA component analysis showed that the intestinal microflora of the model group was different from that of the control group.…”

Section: Discussionsupporting

confidence: 94%

Nuciferine Regulates Immune Function and Gut Microbiota in DSS-Induced Ulcerative Colitis

et al. 2022

View full text Add to dashboard Cite

Nuciferine, a major aporphine alkaloid obtained from the leaves of Nelumbo nucifera, exhibits anti-cancer and anti-inflammatory properties; however, its protective effects against inflammatory bowel diseases (IBD) has never been explored. In this study, an ulcerative colitis (UC) model was established in BALb/c mice by the continuous administration of 5% dextran sulfate sodium (DSS) in drinking water for 1 week. From day 8 to day 14, the DSS-treated mice were divided into a high-dose and a low-dose nuciferine treatment group and were intraperitoneally injected with the corresponding dose of the drug. Body weight loss, disease activity index (DAI), and colon length were measured. Histological changes were observed using hematoxylin and eosin staining. T lymphocyte proliferation was assessed by MTT assay. The ratio of CD3+, CD4+, CD8+, Th1, Th2, Th17, and Treg cells were estimated by flow cytometry. Finally, 16S rRNA sequencing was performed to compare the composition and relative abundance of the gut microbiota among the different treatment groups. The results showed that nuciferine treatment led to a significant improvement in symptoms, such as histological injury and colon shortening in mice with DSS-induced UC. Nuciferine treatment improved the Th1/Th2 and Treg/Th17 balance in the DSS-induced IBD model, as well as the composition of the intestinal microflora. At the phylum level, compared with the control group, the abundance of Firmicutes and Actinobacteriota was decreased in the model group, whereas that of Bacteroidetes increased. Meanwhile, at the genus level, compared with the control group, the numbers of the genera Lachnospiraceae_Clostridium, Bilophila and Halomonas reduced in the model group, while those of Bacteroides, Parabacteroides, and Paraprevotella increased. Notably, nuciferine administration reversed this DSS-induced gut dysbiosis. These results indicated that nuciferine modulates gut microbiota homeostasis and immune function in mice with DSS-induced UC.

show abstract

Section: Discussionsupporting

confidence: 94%

Nuciferine Regulates Immune Function and Gut Microbiota in DSS-Induced Ulcerative Colitis

et al. 2022

View full text Add to dashboard Cite

show abstract

“… 121 In the dextran sulfate sodium (DSS)-induced ulcerative colitis in mice test, DSS was observed to increase the percentage of Oscillospira in the gut. 122 Zhang et al found that patients with chronic kidney disease (CKD) had a high abundance of Oscillospira in the gut. 125 There is also a close association between central neurological and degenerative disorders and Oscillospira .…”

Section: Oscillospira -Related Diseasesmentioning

confidence: 99%

Oscillospira - a candidate for the next-generation probiotics

et al. 2021

View full text Add to dashboard Cite

Oscillospira is a class of organism that often appears in high-throughput sequencing data but has not been purely cultured and is widely present in the animal and human intestines. There is a strong association between variation in Oscillospira abundance and obesity, leanness, and human health. In addition, a growing body of studies has shown that Oscillospira is also implicated in other diseases, such as gallstones and chronic constipation, and has shown some correlation with the positive or negative changes in its course. Sequencing data combined with metabolic profiling indicate that Oscillospira is likely to be a genus capable of producing short-chain fatty acids (SCFAs) such as butyrate, which is an important reference indicator for screening “next-generation probiotics “. Considering the positive effects of Oscillospira in some specific diseases, such as obesity-related metabolic diseases, it has already been characterized as one of the next-generation probiotic candidates and therefore has great potential for development and application in the future food, health care, and biopharmaceutical products.

show abstract

“…Clostridia is Gram-positive anaerobic bacterium that is found in the animal and human guts. 51 Clostridia can help maintain the mucosal barrier in IBD by participating in tryptophan metabolism. 52 FSRP promoted the growth and activity of probiotics in the intestine that metabolize tryptophan.…”

Section: Discussionmentioning

confidence: 99%

Polysaccharides from soybean residue fermented by Neurospora crassa alleviate DSS-induced gut barrier damage and microbiota disturbance in mice

Huang

Deng

et al. 2022

Food Funct.

View full text Add to dashboard Cite

show abstract

Baitouweng Tang ameliorates DSS-induced ulcerative colitis through the regulation of the gut microbiota and bile acids via pathways involving FXR and TGR5

Cited by 51 publications

References 46 publications

Nuciferine Regulates Immune Function and Gut Microbiota in DSS-Induced Ulcerative Colitis

Nuciferine Regulates Immune Function and Gut Microbiota in DSS-Induced Ulcerative Colitis

Oscillospira - a candidate for the next-generation probiotics

Polysaccharides from soybean residue fermented by Neurospora crassa alleviate DSS-induced gut barrier damage and microbiota disturbance in mice

Contact Info

Product

Resources

About