Baiting studies on oral vaccination of the greater kudu (Tragelaphus strepsiceros) against rabies

Hassel, Rainer; Ortmann, Steffen; Clausen, Peter; Jago, Mark; Bruwer, Floris; Lindeque, Pauline; Freuling, Conrad Martin; Vos, Ad; Müller, Thomas

doi:10.1007/s10344-018-1220-z

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Hence, further research should investigate how vaccine uptake effectiveness can be improved, for example by increasing vaccine titre, vaccination intervals or adding muco-adhesive substances. Attractive baits for oral vaccination of Kudus have been developed already 58 , however, bait delivery systems need to be optimized in case vaccine potency can be enhanced in this species. Also, validation of serological assays for Kudus is required to make better informed decisions on the immune status.…”

Section: Discussionmentioning

confidence: 99%

Experimental screening studies on rabies virus transmission and oral rabies vaccination of the Greater Kudu (Tragelaphus strepsiceros)

Hassel

Vos

Clausen³

et al. 2018

Sci Rep

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Rabies in the Greater Kudu (Tragelaphus strepsiceros) in Namibia is unique and found in such magnitude as has not been reported elsewhere in southern Africa. Reasons as to why Kudus appear to be exceptionally susceptible to rabies still remain speculative at best. Because the current severe rabies endemic in Kudus continues to have an enormous negative impact on the Namibian agricultural sector, we set out to question existing dogmas regarding the epidemiology of the disease in a unique experimental setting. In addition, we explored effective measures to protect these antelopes. Although we were able to confirm high susceptibly of kudus for rabies and sporadic horizontal rabies virus transmission to contact animals, we contend that these observations cannot plausibly explain the rapid spread of the disease in Kudus over large territories. Since parenteral vaccination of free-roaming Kudus is virtually impossible, oral rabies vaccination using modified life virus vaccines with a high safety profile would be the ultimate solution to the problem. In a proof-of-concept study using a 3rd generation oral rabies virus vaccine construct (SPBN GASGAS) we found evidence that Kudus can be vaccinated by the oral route and protected against a subsequent rabies infection. In a second phase, more targeted studies need to be initiated by focusing on optimizing oral vaccine uptake and delivery.

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Section: Discussionmentioning

confidence: 99%

Experimental screening studies on rabies virus transmission and oral rabies vaccination of the Greater Kudu (Tragelaphus strepsiceros)

Hassel

Vos

Clausen³

et al. 2018

Sci Rep

Self Cite

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“…For instance, a genetically modified ERA vaccine strain (rERA) with specific mutations induced potent and lasting immune responses in dogs and mice. Other strains like ERAG3G and SPBN GASGAS, developed through reverse genetics, showed high efficacy against pathogenic RABV in mice (86). These genetically modified vaccines represent a significant advancement in RABV prevention.…”

Section: Dna and Rna-based Vaccinesmentioning

confidence: 99%

Guarding Against Rabies: The Power of Vaccination in Rabies Disease Management

Javed

2023

jwmdc

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Rabies, a lethal viral disease caused by the rabies virus, presents a critical public health challenge globally. The disease's etiology involves transmission through the bite or scratch of infected animals, primarily dogs, with the virus targeting the central nervous system and leading to devastating neurological symptoms. Early diagnosis is crucial but challenging due to the disease's non-specific initial manifestations. Vaccination strategies serve as the cornerstone of rabies prevention, encompassing pre-exposure prophylaxis for high-risk individuals and post-exposure prophylaxis for those bitten or scratched by potentially rabid animals. In this article we provide an in-depth exploration of vaccination therapy as a pivotal strategy in the deterrence and management of rabies. The evolution of rabies vaccines, particularly inactivated virus vaccines, is explored, underscoring their role in reducing human rabies cases. The article concludes by emphasizing the significance of continuous research to enhance vaccine effectiveness and promote a comprehensive approach to rabies prevention.

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Rabies Vaccines for Wildlife

Müller

Freuling

2020

Rabies and Rabies Vaccines

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Baiting studies on oral vaccination of the greater kudu (Tragelaphus strepsiceros) against rabies

Cited by 5 publications

References 25 publications

Experimental screening studies on rabies virus transmission and oral rabies vaccination of the Greater Kudu (Tragelaphus strepsiceros)

Experimental screening studies on rabies virus transmission and oral rabies vaccination of the Greater Kudu (Tragelaphus strepsiceros)

Guarding Against Rabies: The Power of Vaccination in Rabies Disease Management

Rabies Vaccines for Wildlife

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