Bailing capsule (Cordyceps sinensis) ameliorates renal triglyceride accumulation through the PPARα pathway in diabetic rats

Zhang, Qian; Xiao, Xinhua; Li, Ming; Yu, Miao; Ping, Fan

doi:10.3389/fphar.2022.915592

Cited by 8 publications

(4 citation statements)

References 53 publications

(60 reference statements)

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“…SCD is a rate-limiting enzyme that converts saturated fatty acids to monounsaturated fatty acids, leading to the formation of neutral lipid droplets [14]. Thus, SCD plays a key role in fatty acid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Study on the Effect of Oleic Acid-Induced Lipogenic Differentiation of Skeletal Muscle Satellite Cells in Yanbian Cattle and Related Mechanisms

Sun,

et al. 2023

Animals

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Skeletal muscle satellite cells have the ability to differentiate into various cells under different conditions. This study aimed to investigate the effects of different concentrations of oleic acid (50, 100, and 200 µmol/L) on the process of lipogenic transdifferentiation in Yanbian bovine satellite cells, as well as its molecular regulatory mechanism. After inducing differentiation with oleic acid for 96 h, it was observed that the addition of oleic acid resulted in the formation of lipid droplets in the bovine satellite cells, and the triglyceride content showed a dose-dependent relationship with the concentration of OA. qPCR results demonstrated a significant downregulation of myogenesis-related factors (Pax3 and MyoD) and upregulation of lipogenesis-related factors (C/EBP-β and PPARγ) (p < 0.05). Fatty acid metabolism-related factors, SCD and PLIN2, were also significantly upregulated (p < 0.05). These finding were consistent with the results obtained from Western blotting. Transcriptome sequencing analysis identified 278 differentially expressed genes between the control group and the groups treated with OA. KEGG enrichment analysis showed that differentially expressed genes were mainly concentrated in the adenosine monophosphate-activated protein kinase signaling pathway and fatty acid metabolic pathway. Our study presents that the OA induction of Yanbian bovine skeletal muscle satellite cells can promote cellular lipid transdifferentiation and reveals the potential genes and pathways related to OA induction of these satellite cells.

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Section: Discussionmentioning

confidence: 99%

Study on the Effect of Oleic Acid-Induced Lipogenic Differentiation of Skeletal Muscle Satellite Cells in Yanbian Cattle and Related Mechanisms

Sun,

et al. 2023

Animals

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“…A meta-analysis of 38 RCT studies involving 3167 patients with DKD showed that Cordyceps sinensis preparations combined with ACEI/ARB significantly reduced 24-hour urinary protein compared with the ACEI/ARB alone group [standardized mean difference (SMD) = -1.99, 95% confidence interval [CI] (-2.68, P<0.05; -1.31, P<0.01], urinary microalbumin [mean difference (MD) = -37.41, 95% CI (-44.76, -30.06), P<0.01], UAER [MD= -24.11, 95% CI (-30.54, P<0.01), -17.68), P<0.01], and ACR [SMD =1.01, 95% CI (-1.73, -0.29), P<0.01], and no significant difference was found in adverse events between the two groups [118]. Cordyceps sinensis preparation can reduce renal TG accumulation in DN rats by regulating the PPARα pathway, thereby reducing glomerulosclerosis, renal tubulointerstitial injury, and renal fibrosis, as well as glomerular proteinuria and renal tubular proteinuria [119]. Based on the comprehensive metabolomics and pattern recognition technology of ultra-performance liquid chromatography-mass spectrometry, it was found that Cordyceps sinensis preparations may play a role in treating DN by searching abnormal metabolic pathways [120].…”

Section: Other Chinese Patent Medicinementioning

confidence: 95%

Understanding Proteinuria in Patients with Diabetic Kidney Disease and Progress of Drug Therapy from a New Perspective

Zhang,

Wang,

Zhou

et al. 2023

Preprint

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Diabetic kidney disease (DKD) is one of the leading causes of end-stage renal disease worldwide and significantly increases the risk of premature death due to cardiovascular diseases. Elevated urinary albumin levels are an important clinical feature of DKD. Effective control of albuminuria not only delays glomerular filtration rate (GFR) decline but also markedly reduces cardiovascular disease risk and all-cause mortality. New drugs for treating DKD proteinuria, including sodium-glucose cotransporter 2 inhibitors (SGLT2i), mineralocorticoid receptor antagonists (MRAs), and endothelin receptor antagonists (REAs), have shown significant efficacy. Auxiliary treatment with proprietary Chinese medicine has also yielded promising results; however, it also faces a broader scope for development. The mechanisms by which these drugs treat albuminuria in patients with DKD should be described more thoroughly. The positive effects of combination therapy with two or more drugs in reducing albuminuria and protecting the kidneys warrant further investigation. Therefore, this review explores the pathophysiological mechanism of albuminuria in patients with DKD, the value of clinical diagnosis and prognosis, new progress and mechanisms of treatment, and multidrug therapy in patients who have type 2 diabetic kidney disease (T2DKD), providing a new perspective on the clinical diagnosis and treatment of DKD.

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“…Using a rat model of unilateral ureteral obstruction (UUO), researchers observed that Cordyceps sinensis can inhibit BAG3 expression, thus reducing renal fibrosis (Liu et al, 2022). The inhibition of the TGF-β1/Smad classic signaling pathway and the reversal of epithelial-mesenchymal transition are among the mechanisms through which Cordyceps sinensis exerts its anti-renal fibrosis effects (Wang et al, 2018;Yang et al, 2020;Zhang et al, 2022). Cordyceps sinensis also exhibits inhibitory effects on the proliferation of human glomerular mesangial cells in vitro (Chen et al, 2019).…”

Section: Go Bioanalysis and Kegg Enrichment Analysismentioning

confidence: 99%

Use of bailing capsules (cordyceps sinensis) in the treatment of chronic kidney disease: a meta-analysis and network pharmacology

Tao,

Luo,

Xiang

et al. 2024

Front. Pharmacol.

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The Bailing Capsule is a commonly used traditional Chinese medicine for the treatment of chronic kidney disease (CKD). However, its therapeutic effects and pharmacological mechanisms have not been fully explored. In this study, we integrated meta-analysis and network pharmacology to provide scientific evidence for the efficacy and pharmacological mechanism of Bailing Capsule in treating CKD. We conducted searches for randomized controlled studies matching the topic in PubMed, the Cochrane Library, Embase, Web of Science, and the Wanfang Database, and screened them according to predefined inclusion and exclusion criteria. Dates from the included studies were extracted for meta-analysis, including renal function indicators, such as 24-h urinary protein (24UP), blood urea nitrogen (BUN), and serum creatinine (Scr), as well as inflammatory indicators like high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Network pharmacology was employed to extract biological information, including active drug ingredients and potential targets of the drugs and diseases, for network construction and gene enrichment. Our findings indicated that 24UP, BUN, and Scr in the treatment group containing Bailing Capsule were lower than those in the control group. In terms of inflammatory indicators, hs-CRP, IL-6, and TNF-α, the treatment group containing Bailing Capsule also exhibited lower levels than the control group. Based on network pharmacology analysis, we identified 190 common targets of Bailing Capsule and CKD. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses suggested that the pharmacological mechanism of Bailing Capsule might be related to immune response, inflammatory response, vascular endothelial damage, cell proliferation, and fibrosis. This demonstrates that Bailing Capsule can exert therapeutic effects through multiple targets and pathways, providing a theoretical basis for its use.

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Bailing capsule (Cordyceps sinensis) ameliorates renal triglyceride accumulation through the PPARα pathway in diabetic rats

Cited by 8 publications

References 53 publications

Study on the Effect of Oleic Acid-Induced Lipogenic Differentiation of Skeletal Muscle Satellite Cells in Yanbian Cattle and Related Mechanisms

Study on the Effect of Oleic Acid-Induced Lipogenic Differentiation of Skeletal Muscle Satellite Cells in Yanbian Cattle and Related Mechanisms

Understanding Proteinuria in Patients with Diabetic Kidney Disease and Progress of Drug Therapy from a New Perspective

Use of bailing capsules (cordyceps sinensis) in the treatment of chronic kidney disease: a meta-analysis and network pharmacology

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