Baicalin reverse AMPA receptor expression and neuron apoptosis in chronic unpredictable mild stress rats

Macranthol promotes hippocampal neuronal proliferation in mice via BDNF–TrkB–PI3K/Akt signaling pathway

“…In the present study, we found that chronic unpredictable mild stress caused a reduction of Bcl-2 expression, but induced an elevation of caspase-3 expression in the hippocampus. Consistent with our study, a recent study also found the decreased Bcl-2 and increased caspase-3 expression in the chronic unpredictable mild stress animals (Yu et al, 2014). Parallel, administration of macranthol increased Bcl-2 and decreased caspase-3 expression.…”

Histological and molecular techniques utilized to investigate animal models of depression. An updated review

“…Atrophy of both hippocampal neurons as well as neurons in the prefrontal cortex was described in mice with heterozygous deletion of BDNF or those exposed to chronic stress (Egan et al, ; Duman, ). The expression of BDNF was apparently reduced in the hippocampus of rats developed depression after being exposed to the CUMS procedure compared with the control group (Ayuob et al, ; Yu et al, ; see Figure ).…”

“…A Terminal Uridine Nick‐End Labeling (TUNEL) assay, utilized to identify DNA fragmentation, and a hallmark of apoptosis, was used by Lee et al () to detect the effect of maternal separation‐induced depression on “programmed cell death” revealed microscopically as apoptosis in rats. In another study conducted by Yu et al () , another set of apoptosis detecting antibodies, included B Cell Lymphoma‐Associated X (BAX), B‐Cell Leukemia Line (BCL‐2) and caspase‐3 was utilized to assess apoptosis. It was reported that CUMS‐induced depression resulted in augmented expression of bax and caspase‐3 and reduced expression of bcl‐2 (Ayuob et al, ; Yu et al, ; see Figure ).…”

“…In another study conducted by Yu et al () , another set of apoptosis detecting antibodies, included B Cell Lymphoma‐Associated X (BAX), B‐Cell Leukemia Line (BCL‐2) and caspase‐3 was utilized to assess apoptosis. It was reported that CUMS‐induced depression resulted in augmented expression of bax and caspase‐3 and reduced expression of bcl‐2 (Ayuob et al, ; Yu et al, ; see Figure ).…”

Baicalin reverse depressive‐like behaviors through regulation SIRT1‐NF‐kB signaling pathway in olfactory bulbectomized rats

“…The anti‐inflammatory actions of baicalin have also been used for brain injury and other diseases (Cao et al, ; Luo et al, ; Zhou et al, ). Notably, previous studies have shown that baicalin has antidepressant‐like effects and decreases serum corticosterone levels in various depression models (Li et al, ; Yu et al, ; Zhang et al, ; Yu et al, ; Zhang et al, ). Although several recent studies have been conducted to investigate the antidepressant effect of baicalin, few studies have evaluated the mechanism of baicalin reverses inflammation on collagen‐induced arthritis in rats, which is related to the elevation of NF‐κB p65 protein deacetylation by SIRT1 (Wang et al, ).…”