Histological and molecular techniques utilized to investigate animal models of depression. An updated review

Ayuob, Nasra Naeim; Balgoon, Maha J.

doi:10.1002/jemt.23105

Cited by 4 publications

(2 citation statements)

References 52 publications

(96 reference statements)

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“…It has been suggested that many brain regions likely play a role in the clinical manifestation of depression. Neuroimaging − and anatomical investigations in humans, ,− as well as animal studies, − found volumetric (e.g., reduction) and histological changes in areas including but not limited to the prefrontal (PFC) and anterior cingulate cortices (ACC), the hippocampus, amygdala, striatum, lateral habenula, thalamus, and hypothalamic areas. Amygdala, habenula and striatal connections are important for emotional regulation, fear response, and reward, and thus likely mediate symptoms such as anhedonia, anxiety and risk aversive behavior, reduced motivation, and bias toward negative stimuli .…”

Section: Neurobiology Of Depressiongenetic Factors Circuitry and Tre...mentioning

confidence: 99%

Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits

Soto,

Gaspar,

Bacci

2024

ACS Chem. Neurosci.

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Depression is one of the most burdensome psychiatric disorders, affecting hundreds of millions of people worldwide. The disease is characterized not only by severe emotional and affective impairments, but also by disturbed vegetative and cognitive functions. Although many candidate mechanisms have been proposed to cause the disease, the pathophysiology of cognitive impairments in depression remains unclear. In this article, we aim to assess the link between cognitive alterations in depression and possible developmental changes in neuronal circuit wiring during critical periods of susceptibility. We review the existing literature and propose a role of serotonin signaling during development in shaping the functional states of prefrontal neuronal circuits and prefronto-thalamic loops. We discuss how early life insults affecting the serotonergic system could be important in the alterations of these local and long-range circuits, thus favoring the emergence of neurodevelopmental disorders, such as depression.

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Section: Neurobiology Of Depressiongenetic Factors Circuitry and Tre...mentioning

confidence: 99%

Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits

Soto,

Gaspar,

Bacci

2024

ACS Chem. Neurosci.

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“…In their recently published article Ayuob and Balgoon have recommended to establish a preclinical behavioral science laboratory in the academic and research institutes in order to encourage and support the conduction of high quality multidisciplinary researches targeting anxiety and other psychiatric disorders (7). They postulated that such type of laboratories will indirectly participate in improving the health care.…”

Section: Introductionmentioning

confidence: 99%

Preferences of Academic Researches and Pattern of Utilization of Behavior Laboratory Science for Preclinical Researches - a Cross Sectional Study

Alghamdi

2019

Med Arch

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Introduction:Several studies confirmed the relation between mortality, behavioral and social factors and emphasized the importance of behavioral and social science to public health practice.Aim:This study aimed to determine the preferences of the researchers who utilize the behavioral sciences laboratory at the Preclinical Research Unit and define the patter of laboratory utilization in order to maximize the benefits gained from it.Methods:This cross sectional study conducted at the KFMRC, KAU, Jeddah, Saudi Arabia in 2018 on the researchers who visited the behavior research laboratory between October 2018 and December 2018. A structured self-administered questionnaire was utilized to collect the demographic data and preferences of the participants and the pattern of utilization of the behavior science laboratory. The response rate was 100%. The Data were analyzed using the Statistical Package of Social Sciences (SPSS) version 21.Results:About 47% of the participants were working at the faculty of medicine (FOM) and about 47% were assistant professor. About 53 had previously conducted researches in behaviors science field. The majority of the participants were interested in memory field (about 57%) followed by the social field (20%). The least attractive field were the nutritional and anxiety (1.4%). The percent of non-medical researchers who had no interest in co-ordination field was significantly higher (p=0.041) compared to the medical/paramedical specialists.Conclusion:This study shed the light on the relative reduced interest in behavior researches among the academic researchers. There is need for more orientation programs and campaigns to raise the awareness of the importance of behaviors researches laboratories and researches.

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St John’s wort (Hypericum perforatum L)

Coppock¹,

Dziwenka²

2021

Nutraceuticals

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Histological and molecular techniques utilized to investigate animal models of depression. An updated review

Abstract: Chronic stress models are valid ones. Light microscope was utilized to examine the routinely or immunohistochemically stained sections in hippocampus of animal models of depression while electron microscope was utilized to examine its ultrastructure.

Cited by 4 publications

References 52 publications

Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits

Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits

Preferences of Academic Researches and Pattern of Utilization of Behavior Laboratory Science for Preclinical Researches - a Cross Sectional Study

St John’s wort (Hypericum perforatum L)

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