Baicalin Induces Apoptosis and Suppresses the Cell Cycle Progression of Lung Cancer Cells Through Downregulating Akt/mTOR Signaling Pathway

Sui, Xinbing; Han, Xiao‐Jian; Chen, Peng; Wu, Qibiao; Jiao, Feng; Duan, Ting; Chen, Xiaying; Pan, Ting; Yan, Lili; Jin, Tengchuan; Yu, Xiang; Gao, Quan; Wen, Chengyong; Ma, Weirui; Liu, Wen‐Cheng; Zhang, Ruonan; Bi, Chen; Zhang, Mingming; Yang, Zaixing; Kong, Na; Xie, Tian; Ding, Xia

doi:10.3389/fmolb.2020.602282

Cited by 34 publications

(16 citation statements)

References 18 publications

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“…We investigated baicalin effects on lung cancer cells proliferation and invasion. After treatment with 10, 30, 60, 90, 120, and 150 µg/ml baicalin concentrations [ 18 ] at two time points (24 h and 48 h), cell proliferation was reduced, and efficacy was dose- and time-dependent ( Figure 1b-e ). Colony formation data indicated baicalin significantly limited in vitro cell proliferation ( Figure 2a and 2b ).…”

Section: Resultsmentioning

confidence: 99%

Baicalin suppresses lung cancer growth phenotypes via miR-340-5p/NET1 axis

Zhao

Han

et al. 2021

Bioengineered

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As a malignant disease, lung cancer has a high morbidity and mortality rate. Baicalin is derived from Radix Scutellariae and has anti-tumor effects, however, its role in lung cancer remains unknown. Here, functional assays suggested baicalin suppressed in vitro lung cancer phenotypes. We used micro (mi)RNA array analysis to explore baicalin effects on miRNA expression. We observed baicalin increased miR-340-5p expression, whereas inhibition of this expression abolished anti-tumor effects of baicalin. Furthermore, neuroepithelial cell transforming 1 (NET1) functioned as a miR-340-5p target, and acted in a baicalin-dependent manner to regulate lung cancer progression. Thus, baicalin elicited antitumor activities by affecting the miR-340-5p/NET1 axis, suggesting a new approach to lung cancer clinical management.

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Section: Resultsmentioning

confidence: 99%

Baicalin suppresses lung cancer growth phenotypes via miR-340-5p/NET1 axis

Zhao

Han

et al. 2021

Bioengineered

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“…Interestingly, Baicalin has been utilized for centuries as a traditional Chinese herbal medicine for curing psoriasis, inflammation, hypertension, cardiovascular diseases, etc. [ 35 ]. Other plant species in which it is present and isolated are S. lateriflora , S. galericulata and Thalictrum baicalense [ 36 ].…”

Section: Sources and Chemistry Of Scutellaria Flav...mentioning

confidence: 99%

Autophagy Induction by Scutellaria Flavones in Cancer: Recent Advances

Tuli

Bhushan

Kumar³

et al. 2023

Pharmaceuticals

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In parallel with a steady rise in cancer incidence worldwide, the scientific community is increasingly focused on finding novel, safer and more efficient modalities for managing this disease. Over the past decades, natural products have been described as a significant source of new structural leads for novel drug candidates. Scutellaria root is one of the most studied natural products because of its anticancer potential. Besides just describing the cytotoxic properties of plant constituents, their molecular mechanisms of action in different cancer types are equally important. Therefore, this review article focuses on the role of the Scutellaria flavones wogonin, baicalein, baicalin, scutellarein and scutellarin in regulating the autophagic machinery in diverse cancer models, highlighting these molecules as potential lead compounds for the fight against malignant neoplasms. The knowledge that autophagy can function as a dual-edged sword, acting in both a pro- and antitumorigenic manner, further complicates the issue, revealing an amazing property of flavonoids that behave either as anti- or proautophagic agents.

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“… Sui et al (2020) found that 20 mg/kg of BA can trigger apoptosis and block cell cycle G1/S transition in carcinoma of the lung cells via the AKT/mechanistic target of rapamycin (mTOR) pathway. NSCLC is highly prone to invasion and metastasis, which are closely associated with the occurrence of EMT ( Xia et al, 2014 ).…”

Section: The Protection Of Ba Against Respiratory Diseasesmentioning

confidence: 99%

The protective effects of baicalin for respiratory diseases: an update and future perspectives

Song

Liu

et al. 2023

Front. Pharmacol.

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Background: Respiratory diseases are common and frequent diseases. Due to the high pathogenicity and side effects of respiratory diseases, the discovery of new strategies for drug treatment is a hot area of research. Scutellaria baicalensis Georgi (SBG) has been used as a medicinal herb in China for over 2000 years. Baicalin (BA) is a flavonoid active ingredient extracted from SBG that BA has been found to exert various pharmacological effects against respiratory diseases. However, there is no comprehensive review of the mechanism of the effects of BA in treating respiratory diseases. This review aims to summarize the current pharmacokinetics of BA, baicalin-loaded nano-delivery system, and its molecular mechanisms and therapeutical effects for treating respiratory diseases.Method: This review reviewed databases such as PubMed, NCBI, and Web of Science from their inception to 13 December 2022, in which literature was related to “baicalin”, “Scutellaria baicalensis Georgi”, “COVID-19”, “acute lung injury”, “pulmonary arterial hypertension”, “asthma”, “chronic obstructive pulmonary disease”, “pulmonary fibrosis”, “lung cancer”, “pharmacokinetics”, “liposomes”, “nano-emulsions”, “micelles”, “phospholipid complexes”, “solid dispersions”, “inclusion complexes”, and other terms.Result: The pharmacokinetics of BA involves mainly gastrointestinal hydrolysis, the enteroglycoside cycle, multiple metabolic pathways, and excretion in bile and urine. Due to the poor bioavailability and solubility of BA, liposomes, nano-emulsions, micelles, phospholipid complexes, solid dispersions, and inclusion complexes of BA have been developed to improve its bioavailability, lung targeting, and solubility. BA exerts potent effects mainly by mediating upstream oxidative stress, inflammation, apoptosis, and immune response pathways. It regulates are the NF-κB, PI3K/AKT, TGF-β/Smad, Nrf2/HO-1, and ERK/GSK3β pathways.Conclusion: This review presents comprehensive information on BA about pharmacokinetics, baicalin-loaded nano-delivery system, and its therapeutic effects and potential pharmacological mechanisms in respiratory diseases. The available studies suggest that BA has excellent possible treatment of respiratory diseases and is worthy of further investigation and development.

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Baicalin Induces Apoptosis and Suppresses the Cell Cycle Progression of Lung Cancer Cells Through Downregulating Akt/mTOR Signaling Pathway

Cited by 34 publications

References 18 publications

Baicalin suppresses lung cancer growth phenotypes via miR-340-5p/NET1 axis

Baicalin suppresses lung cancer growth phenotypes via miR-340-5p/NET1 axis

Autophagy Induction by Scutellaria Flavones in Cancer: Recent Advances

The protective effects of baicalin for respiratory diseases: an update and future perspectives

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