Baicalin and ginsenoside Rb1 promote the proliferation and differentiation of neural stem cells in Alzheimer’s disease model rats

Zhao, Jiwei; Lu, Shanshan; Yu, Hongli; Duan, Shanshan; Zhao, Jingkun

doi:10.1016/j.brainres.2017.10.003

Cited by 50 publications

(31 citation statements)

References 30 publications

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“…The Nestin as an intermediate filament protein, which can be specifically label neural stem cells and has a certain maintenance and promotion effect on neuronal differentiation. The positive expression of Nestin was mainly concentrated in the cytoplasm (Yu et al, ; Zhao et al, ). Our immunohistochemical results showed that positive expression of Nestin was no significant difference in the hippocampus of mice between the control group and the saline group (Fig.…”

Section: Resultsmentioning

confidence: 99%

Volatile Oil from Acorus gramineus Ameliorates the Injury Neurons in the Hippocampus of Amyloid Beta 1‐42 Injected Mice

Gao

Hong-qing²,

et al. 2019

The Anatomical Record

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In recent years, the extraction fraction of volatile oil from Acorus gramineus has significant effects on anti‐dementia and improving the learning and memory of animals. To date, limited studies have determined whether volatile oil from A. gramineus has the protective effect on neuronal damage. The aim of this study was to investigate the protective effects of volatile oil from A. gramineus on Alzheimer's disease (AD) mice, by means of behavior test, immunohistochemistry and western blot methods. In this study, mice were injected with Aβ1‐42 in the bilateral hippocampus to establish the AD model. On the seventh day after modeling, the mice with cognitive dysfunction were selected by the novel object recognition task. Subsequently, the volatile oil treatment groups underwent intragastric administration for per 10 g body weight 2.5 or 5 μL volatile oil from A. gramineus for 3 weeks. The control group and the AD group were given the same amount of saline. Our results showed that after treatment of volatile oil from A. gramineus, the number of Doublecortin and Nestin positive cells increased significantly, suggesting that the volatile oil from A. gramineus may induce the regeneration of hippocampal neurons in mice, and promote the growth of hippocampal neurons by upregulation of brain‐derived neurotrophic factor, tyrosine protein kinase B, and neurotrophin‐3 expression. These results might provide more experimental evidences for underlying mechanism about the neuroprotective effects of volatile oil from A. gramineus against AD relevant symptoms. Anat Rec, 302:2261–2270, 2019. © 2019 American Association for Anatomy

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Section: Resultsmentioning

confidence: 99%

Volatile Oil from Acorus gramineus Ameliorates the Injury Neurons in the Hippocampus of Amyloid Beta 1‐42 Injected Mice

Gao

Hong-qing²,

et al. 2019

The Anatomical Record

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“…Moreover, Rd reverses the cognitive dysfunction and increase of Iba‐1 and caspase‐3 expression in a rat model with Aβ1‐40 . Additionally, ginseng or Rb1 also activate astrocytes and inhibit oxidative stress in a mouse model of cerebral hypoxic ischemia and promote the proliferation of neural stem cells in rats injected with Aβ1‐40 . Thus, FG might induce beneficial effects, such as neurogenesis or neuroprotection, via activated astrocytes in the CI + Aβ‐operated rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus paracasei A221‐fermented ginseng on impaired spatial memory in a rat model with cerebral ischemia and β‐amyloid injection

Nagao

Yamano

Imagawa

et al. 2019

Traditional & Kampo Medicine

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Aim: Ginseng, a traditional herbal medicine, has been shown to prevent the progression of dementia, but its therapeutic effects vary because ginseng's components must first be activated by intestinal bacteria before being absorbed into the blood. We therefore focused on a fermented ginseng (FG), which contains activated components prepared by Lactobacillus paracasei A221, and compared its effects with those of non-FG. In this study, we investigated whether FG is effective on spatial memory impairment in rats. Methods: Rats with spatial memory impairment were prepared with transient cerebral ischemia and intraventricular injection of β-amyloid 1-42 for 7 days (CI + Aβ). Oral FG or non-FG was given for 7 days after the cerebral ischemia. Spatial memory was evaluated using the Morris water maze (MWM). We observed neuronal neuclei-positive cells to assess hippocampal neuron loss, and investigated the protein expression of caspase-3 and cleaved caspase-3 for neuronal apoptosis, ionized calciumbinding adapter molecule 1 (Iba-1) for microglia, and glial fibrillary acidic protein for astrocytes. Results: FG treatment in the CI + Aβ-operated rats shortened the extended time to reach the platform in the MWM, whereas non-FG treatment did not affect the extended time. FG ameliorated loss of hippocampal cornu amonis (CA)1 neurons and the increase in caspase-3 and Iba-1 in the CI + Aβ-operated rats. Conclusion: FG improved spatial memory impairment in CI + Aβ-operated rats. The effect of FG might be attributed to the amelioration of apoptotic neuronal cell death and the inactivation of microglia. FG is a more useful treatment for patients with cognitive dysfunction than non-FG.

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“…S. baicalensis, H. erinaceus and R. rosea produce neuroprotective effects in models of Parkinson's disease (PD) [6,7,12,17,68,69], Alzheimer's disease (AD) [11,[70][71][72][73][74][75][76][77][78][79], Huntington disease (HD) [18], hypoxia/hypo-perfusion/stroke [51,80,81], nerve and brain injury [82,83], glutamate-induced neurotoxicity [16,75,84], and epilepsy [85][86][87]. The in vitro and in vivo neuroprotective effects of these herbal compounds, administered as either full/enriched herbal extracts and/or as single bioactive ingredients, are largely attributable to antioxidant, mitochondrial-protecting and anti-inflammatory activities ( Figure 2).…”

Section: Common Neuroprotective Effects Of S Baicalensis H Erinacementioning

confidence: 99%

“…Despite being assessed in neurotoxicity models, these effects may be also key for depressive-related disorders, where oxidative stress, mitochondrial alterations and inflammation are widely implicated [34]. As a further common effect which is relevant to both neurodegenerative and mental disorders, these herbs also promote neurogenesis, neuronal differentiation and the synthesis of neurotrophic factors [8,12,72,74], and they enhance the release of dopamine (DA), norepinephrine (NE) and serotonin (5-HT), in part by acting as monoamine oxidase (MAO) inhibitors [6,7,12,[88][89][90][91]. Nonetheless, at a closer look, each herb also possesses specific effects which may complementarily contribute to their mood-stabilizing potential beyond neuroprotection.…”

Section: Common Neuroprotective Effects Of S Baicalensis H Erinacementioning

confidence: 99%

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

et al. 2020

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Recent studies focused on the pharmacology and feasibility of herbal compounds as a potential strategy to target a variety of human diseases ranging from metabolic to brain disorders. Accordingly, bioactive ingredients which are found within a variety of herbal compounds are reported to produce both neuroprotective and psychotropic activities which may help to combat mental disorders such as depression, anxiety, sleep disturbances and cognitive alterations. In the present manuscript, we focus on three herbs which appear effective in mitigating anxiety or depression with favourable risk-benefit profiles, namely Scutellaria baicalensis (S. baicalensis), Hericium erinaceus (H. erinaceus) and Rhodiola rosea (R. rosea). These three traditional folk medicinal herbs target the main biochemical events that are implicated in mental disorders, mimicking, to some extent, the mechanisms of action of conventional antidepressants and mood stabilizers with a wide margin of tolerability. In detail, they rescue alterations in neurotransmitter and neuro-endocrine systems, stimulate neurogenesis and the synthesis of neurotrophic factors, and they counteract oxidative stress, mitochondrial dysfunction and inflammation. Albeit the encouraging results that emerge from both experimental and clinical evidence, further studies are needed to confirm and better understand the mental-health promoting, and specifically, the antidepressant effects of these herbs.

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Baicalin and ginsenoside Rb1 promote the proliferation and differentiation of neural stem cells in Alzheimer’s disease model rats

Cited by 50 publications

References 30 publications

Volatile Oil from Acorus gramineus Ameliorates the Injury Neurons in the Hippocampus of Amyloid Beta 1‐42 Injected Mice

Volatile Oil from Acorus gramineus Ameliorates the Injury Neurons in the Hippocampus of Amyloid Beta 1‐42 Injected Mice

Effect of Lactobacillus paracasei A221‐fermented ginseng on impaired spatial memory in a rat model with cerebral ischemia and β‐amyloid injection

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

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