Baicalin ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 signaling pathway

Meng, Xiangli; Hu, Lin; Li, Wenqiang

doi:10.1007/s00210-019-01680-9

Cited by 64 publications

(40 citation statements)

References 33 publications

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“… Compounds Structure In vitro/in vivo Model (effective dose) Cells (effective concentration) Related pharmacological indicators Related molecular mechanisms Refs. Luteolin 1 LPS/CLP (1 mg/kg) RAW 264.7 (20 μM) MPO↓ TNF-α↓ IL1-β↓ IL-6↓ MDA↓ SOD↑ CAT↑ GSH↑ COX-2↓ iNOS↓ ICAM-1↓ HMGB1↓ Inhibition of PI3K/Akt-mediated NF-κB and MAPK signaling pathways Activation of ERK1/2- and Ca 2+ -dependent HO-1 induction [ [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] ] Baicalein 2 CLP/I/R (10 mg/kg) MPMs (2.5 μM) MPO↓ TNF-α↓ IL1-β↓ IL-6↓ ICAM-1↓ IL-12↓ MCP-1↓ Inhibition of TLR4-MD2- MAPKs/ NF-κB signaling pathways Upregulation of Nrf2/HO-1 signaling pathway Inhibition of Bax/Bcl-2-mediated apoptosis [ [74] , [75] , [76] ] Baicalin 3 LPS/ Burn/RSV/IAV/APEC/ SiO 2 /Air embolism/Paraquat /Cigarette smoke/Pancreas (20 mg/kg) MPO↓ TNF-α↓ IL1-β↓ IL-6↓ IL-8↓IL-23↓ MDA↓ SOD↑ CAT↑ IL-18↓ TGF-β↓ HMGB1↓ Activation of Nrf2/HO-1 signaling pathway Inhibition of NLRP3 inflammasome Inhibition of the crosstalk between CX3CL1-CX3CR1 axis and NF-κB pathway Up-regulation of autophagy Inhibition of PI3K/AKT/ NF-κB signaling pathway [ [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] , [87] ] Tanshinone IIA 4 LPS/Paraquat/Blast/Pancreatitis /Seawater...…”

Section: Mechanisms Involved In Ali/ardsmentioning

confidence: 99%

“…Baicalin 3 , also one of the principal constituents extracted from Chinese medicinal plant Scutellaria baicalensis Georgi, can alleviate lung impairment as shown by attenuated MPO activity, lung edema and lung histopathologic changes in ALI models induced by various stimuli such as LPS, burn, respiratory syncytial virus (RSV), Influenza A virus (IAV), SiO 2 , air embolism, paraquat, cigarette smoke or pancreatitis [ [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] ]. Baicalin could alleviate pulmonary inflammation through down-regulating expression of pro-inflammatory cytokines TNF-a, IL-1β, IL-6, IL-8, IL-18, IL-23 and MMP9 [ 77 ].…”

Section: Natural Compounds That Exert Anti-ali Effectsmentioning

confidence: 99%

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Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

220

121

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Section: Mechanisms Involved In Ali/ardsmentioning

confidence: 99%

Section: Natural Compounds That Exert Anti-ali Effectsmentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

220

121

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“…Nrf2/HO-1 signaling was also affected by the water extract of Forsythiae Fructus which suppressed inflammation and disrupted inflammatory signaling cascade ( Lee et al., 2018 ). Baicalin protected against LPS-induced severe lung injury by activating an antioxidant system and reducing both the number of inflammatory cells and expression of mediators via the Nrf2/HO-1 signaling pathway ( Meng et al., 2019 ). Moreover, it exerted beneficial effect on lung function as shown by anti-airway remodeling through regulating the release of proinflammatory cytokine in long-term cigarette smoke-induced chronic obstructive pulmonary disease model ( Wang et al., 2018 ).…”

Section: Mechanisms Of Tcm Function In Treating Covid-19mentioning

confidence: 99%

Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism

Zhang

et al. 2021

Phytomedicine

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Background Coronavirus disease-2019 (COVID-19) caused by infection with severe acute respiratory coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout China and in other countries since the end of 2019. The World Health Organization (WHO) has declared that the epidemic is a public health emergency of international concerns. The timely and appropriate measures for treating COVID-19 in China, which are inseparable from the contribution of traditional Chinese medicine (TCM), have won much praise of the world. Purpose This review aimed to summarize and discuss the essential role of TCM in protecting tissues from injuries associated with COVID-19, and accordingly to clarify the possible action mechanisms of TCM from the perspectives of anti-inflammatory, antioxidant and anti-apoptotic effects. Methods Electronic databases such as Pubmed, ResearchGate, Science Direct, Web of Science, medRixv and Wiley were used to search scientific literatures. Results The present review found that traditional Chinese herbs commonly used for the clinical treatment of organ damages caused by COVID-19, such as Scutellaria baicalensis, Salvia miltiorrhizaSalvia miltiorrhiza , and ginseng, could act on multiple signaling pathways involved in inflammation, oxidative stress and apoptosis. Conclusion TCM could protect COVID-19 patients from tissue injuries, a protection that might be, at least partially, attributed to the anti-inflammatory, antioxidant and anti-apoptotic effects of the TCM under investigation. This review provides evidence and support for clinical treatment and novel drug research using TCM.

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“…Recent studies have indicated that BA has many pharmacological activities, like anti-inflammation [ 9 ], antioxidative stress [ 10 ], neuroprotective [ 11 ], and antibacterial [ 12 ]. Increasing researches have showed that BA has a protective effect on ALI induced by LPS [ 13 ]. However, BA has a low solubility due to the existence of glycosyl groups in the molecular structure.…”

Section: Introductionmentioning

confidence: 99%

Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway

Long

Yan

Liu

et al. 2020

Mediators of Inflammation

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Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are challenging diseases with the high mortality in a clinical setting. Baicalin (BA) is the main effective constituent isolated from the Chinese medical herb Scutellaria baicalensis Georgi, and studies have proved that it has a protective effect on ALI induced by lipopolysaccharide (LPS) due to the anti-inflammatory efficacy. However, BA has low solubility which may limit its clinical application. Hence, we prepared a novel drug delivery system—Baicalin liposome (BA-LP) in previous research—which can improve some physical properties of BA. Therefore, we aimed to explore the effect of BA-LP on ALI mice induced by LPS. In pharmacokinetics study, the values of t 1 / 2 and AUC0- t in the BA-LP group were significantly higher than that of the BA group in normal mice, indicating that BA-LP could prolong the duration time in vivo of BA. The BA-LP group also showed a higher concentration in lung tissues than the BA group. Pharmacodynamics studies showed that BA-LP had a better effect than the BA group at the same dosage on reducing the W/D ratio, alleviating the lung injury score, and decreasing the proinflammatory factors (TNF-α, IL-1β) and total proteins in bronchoalveolar lavage fluids (BALF). In addition, the therapeutic effects of BA-LP showed a dose-dependent manner. Western blot analysis indicated that the anti-inflammatory action of BA could be attributed to the inhibition of the TLR4-NFκBp65 and JNK-ERK signaling pathways. These results suggest that BA-LP could be a valuable therapeutic candidate in the treatment of ALI.

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Baicalin ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 signaling pathway

Cited by 64 publications

References 33 publications

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism

Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway

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