Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway

You, Jiawen; Cheng, Jun; Yu, Bing; Duan, Changhua; Peng, Jinghua

doi:10.12659/msm.909627

Cited by 56 publications

(50 citation statements)

References 27 publications

(25 reference statements)

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“…AMPK not only senses the changes in cellular energy levels, but also responds to reactive oxygen species and activates processes such as apoptosis and autophagy [38]. A recent study demonstrated AMPK-mediated inhibition of cancer cell proliferation by BC [39]. As shown in Figure 3, we observed an altered AMPK phosphorylation in the BPH group as compared to the control group.…”

Section: Discussionsupporting

confidence: 53%

Baicalin alleviates benign prostate hyperplasia through androgen-dependent apoptosis

Jin

2020

Aging

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BPH is a disease prevalent among elderly men that is characterized by abnormal proliferation of prostatic epithelial and stromal tissues. No effective treatment exists for BPH owing to lack of a clear understanding of its molecular etiology. Although several studies have reported therapeutic effects of baicalin against numerous diseases, including prostate cancer, its beneficial effects on BPH have not yet been explored. The present study investigated the therapeutic effects of baicalin on the development of BPH and its mechanism of action. We established a testosterone-treated BPH animal model and DHT-stimulated prostate cell lines, including RWPE-1 and WPMY-1. Administration of baicalin ameliorated the pathological prostate enlargement, suppressed the production of DHT, and inhibited the activity of 5α-reductase Type II in the animal model. BC exerted these effects via its anti-proliferative effects by restoring the Bax/Bcl-2 ratio, activating caspase-3 and caspase-8, and inducing the phosphorylation of AMPK. In vitro studies using DHT-stimulated prostate cells demonstrated an up-regulation of BPH-related and proliferation markers, whereas baicalin clearly reduced the overexpression of AR, PSA, PCNA, and Bcl-2. These results suggested that baicalin could suppress androgen-dependent development of BPH both in vivo and in vitro by inducing apoptosis.

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Section: Discussionsupporting

confidence: 53%

Baicalin alleviates benign prostate hyperplasia through androgen-dependent apoptosis

Jin

2020

Aging

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“…A natural polyphenolic compound, resveratrol, has been shown to promote the expression of SIRT1 in rat ovarian granulosa cells, which implicated the important role of SIRT1 in ovarian function [33]. It has been shown that BAL inhibits the proliferation and migration of human non-small cell lung carcinoma cells through activation of the SIRT1/AMPK signaling pathway [15]. In contrast, Xu et al showed that BAL inhibited SIRT1-induced regulation of signal transducer and activator of transcription 3 (STAT3), leading to the suppression of excessive hepatic glucose production [34].…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, we aimed to evaluate the effects of BAL on the dysregulation of hormones, histological changes of the ovary, and metabolic disorder in PCOS rats. Previous literature and our preliminary studies have suggested that activation of AMP-activated protein kinase (AMPK) is associated with the beneficial effects of BAL [15]. Thus, we examined the potential involvement of AMPK in BAL-induced effects on PCOS rats.…”

Section: Introductionmentioning

confidence: 94%

Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase

et al. 2019

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Polycystic ovary syndrome (PCOS) is a complex endocrine disorder and regarded as the leading cause of anovulatory infertility. PCOS is characterized by reproductive dysfunction and metabolic disorders. Baicalin (BAL) is one of the most potent bioactive flavonoids isolated from the radix of Scutellaria baicalensis. In the present study, we investigated the potential effects of BAL on PCOS in dehydroepiandrosterone-treated rats. We found that BAL notably reduced the serum levels of free testosterone, total testosterone, follicle-stimulating hormone, luteinizing hormone, progesterone, and estradiol in PCOS rats. The increase of serum insulin level and HOMA-IR was markedly inhibited by BAL. Moreover, BAL decreased body weights, increased the number of rats with the regular estrous cycle, and ameliorated ovarian histological changes and follicular development in the DHEA-treated PCOS rats. The increase of pro-inflammatory cytokines (TNFα, IL-1β, and IL-18) and decrease of anti-inflammatory cytokine (IL-10) in PCOS rats were suppressed by BAL. BAL induced a significant decrease in the mRNA expression of steroidogenic enzymes, including 3β-HSD, CYP11A1, CYP19A1, StAR, in ovarian tissues in PCOS rats. Furthermore, BAL inhibited the decrease of AMPK protein level and phosphorylation, the decrease of Akt phosphorylation and the increase of 5α-reductase enzyme 1 expression in ovarian tissues in PCOS rats. The effects of BAL were inhibited by an inhibitor of AMPK, dorsomorphin. The upregulation of AMPK contributed to the beneficial effects of BAL. The results highlight the potential role of BAL for the intervention of PCOS.

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“…The abnormal increase in estrogens and their metabolites can easily lead to cholestasis, which results in the impairment of bile flow and hepatotoxicity (Trauner et al, 1998). Baicalin is the main flavonoid component isolated from the traditional Chinese medicine Scutellaria baicalensis (You et al, 2018). In previous studies, it has been revealed that baicalin possess effective therapeutic effects on liver diseases (Guo et al, 2009;Dai et al, 2018;Xu et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Baicalin Protects Against 17α-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1α/Farnesoid X Receptor Pathway

Yang

Xiang

et al. 2020

Front. Pharmacol.

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Estrogen-induced cholestasis (EIC) is characterized by impairment of bile flow and accumulated bile acids (BAs) in the liver, always along with the liver damage. Baicalin is a major flavonoid component of Scutellaria baicalensis, and has been used in the treatment of liver diseases for many years. However, the role of baicalin in EIC remains to be elucidated. In this study, we demonstrated that baicalin showed obvious hepatoprotective effects in EIC rats by reducing serum biomarkers and increasing the bile flow rate, as well as by alleviating liver histology and restoring the abnormal composition of hepatic BAs. In addition, baicalin protected against estrogen-induced liver injury by up-regulation of the expression of hepatic efflux transporters and down-regulation of hepatic uptake transporters. Furthermore, baicalin increased the expression of hepatic BA synthase (CYP27A1) and metabolic enzymes (Bal, Baat, Sult2a1) in EIC rats. We showed that baicalin significantly inhibited hepatic inflammatory responses in EIC rats through reducing elevated levels of TNF-a, IL-1b, IL-6, and NF-kB. Finally, we confirmed that baicalin maintains hepatic BA homeostasis and alleviates inflammation through sirtuin 1 (Sirt1)/hepatic nuclear receptor-1a (HNF-1a)/ farnesoid X receptor (FXR) signaling pathway. Thus, baicalin protects against estrogeninduced cholestatic liver injury, and the underlying mechanism involved is related to activation of the Sirt1/HNF-1a/FXR signaling pathway.

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Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway

Cited by 56 publications

References 27 publications

Baicalin alleviates benign prostate hyperplasia through androgen-dependent apoptosis

Baicalin alleviates benign prostate hyperplasia through androgen-dependent apoptosis

Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase

Baicalin Protects Against 17α-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1α/Farnesoid X Receptor Pathway

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