Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase

Wang, Wei; Zheng, Jia‐Hua; Cui, Na; Jiang, Lei; Zhou, Han; Zhang, Dan; Hao, Guimin

doi:10.1186/s13048-019-0585-2

Cited by 34 publications

(22 citation statements)

References 43 publications

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“…In addition, Cyp11a1 and Fdx1 promoter activity was also enhanced by co-treatments with cAMP as reported for apigenin (2), luteolin (3), and chrysin (1). However, others recently reported that baicalein (4) administration for four weeks reduced serum testosterone and FSH and LH levels following treatments of a rat model for polycystic ovary syndrome (PCOS) [43]. In their study, baicalein (4) instead decreased the expression of StAR, Hsd3b, Cyp11a1, and Cyp19a1 in ovarian tissues.…”

Section: Flavonesmentioning

confidence: 86%

Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism

Martin

Touaibia

2020

Antioxidants

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Androgen production, being important for male fertility, is mainly accomplished by the Leydig cells from the interstitial compartment of the testis. Testosterone plays a critical role in testis development, normal masculinization, and the maintenance of spermatogenesis. Within seminiferous tubules, appropriate Sertoli cell function is highly dependent on testicular androgen levels and is essential to initiate and maintain spermatogenesis. During aging, testosterone production by the testicular Leydig cells declines from the 30s in humans at a rate of 1% per year. This review outlines the recent findings regarding the use of flavonoids and isoflavonoids to improve testosterone production, contributing to normal spermatogenesis and preventing age-related degenerative diseases associated with testosterone deficiency. With the cumulation of information on the actions of different flavonoids and isoflavonoids on steroidogenesis in Leydig cells, we can now draw conclusions regarding the structure-activity relationship on androgen production. Indeed, flavonoids having a 5,7-dihydroxychromen-4-one backbone tend to increase the expression of the steroidogenic acute regulatory protein (StAR), being critical for the entry of cholesterol into the mitochondria, leading to increased testosterone production from testis Leydig cells. Therefore, flavonoids and isoflavonoids such as chrysin, apigenin, luteolin, quercetin, and daidzein may be effective in delaying the initiation of late-onset hypogonadism associated with aging in males.

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Section: Flavonesmentioning

confidence: 86%

Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism

Martin

Touaibia

2020

Antioxidants

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“…Natural compounds have high potential in PCOS therapy. Flavonoid baicalin (isolated from Scutellaria baicalensis ) has been shown to decrease levels of testosterone, LH, progesterone and estradiol, and several proinflammatory cytokines (IL-1β, IL-18 and TNFα) and normalise IR in PCOS-induced rats [ 96 ]. Similarly, flavonoids recovered from Nervilia Fordii decrease the levels of IL-6 and hormones LH, testosterone and insulin and increase the serum level of FSH [ 97 ].…”

Section: Pcos Treatments: Classical and Modern Mitochondria–oriented Approachesmentioning

confidence: 99%

Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome

Dabravolski

Nikiforov

Eid

et al. 2021

IJMS

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Polycystic ovarian syndrome (PCOS) is the most common endocrine–metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA have been identified in PCOS patients and likely play an important role in PCOS aetiology and pathogenesis; however, their causative role in PCOS development requires further investigation. As a low-grade chronic inflammation disease, PCOS patients have permanently elevated levels of inflammatory markers (TNF-α, CRP, IL-6, IL-8, IL-18). In this review, we summarise recent data regarding the role of mtDNA mutations and mitochondrial malfunctions in PCOS pathogenesis. Furthermore, we discuss recent papers dedicated to the identification of novel biomarkers for early PCOS diagnosis. Finally, traditional and new mitochondria-targeted treatments are discussed. This review intends to emphasise the key role of oxidative stress and chronic inflammation in PCOS pathogenesis; however, the exact molecular mechanism is mostly unknown and requires further investigation.

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“…In human granulosa cells, through AMPK-dependent mechanisms, MF suppresses the tumor necrosis factor-α (TNF-α)-induced production of pro-inflammatory cytokines, interleukin-8 and chemokine CXCL1/GROα [ 303 ]. The other AMPK activators, such as AICAR and Baicalin, also reduce TNF-α- and chemokine-mediated inflammatory responses in ovarian cells [ 303 , 304 ]. In PCOS ovarian cells, the mechanism of MF suppressive effect on the TNF-α-induced cascades includes a decrease in the gene expression of TNF-α [ 217 ].…”

Section: Metformin and Polycystic Ovary Syndromementioning

confidence: 99%

Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms

2021

Pharmaceuticals

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Metformin (MF), a first-line drug to treat type 2 diabetes mellitus (T2DM), alone and in combination with other drugs, restores the ovarian function in women with polycystic ovary syndrome (PCOS) and improves fetal development, pregnancy outcomes and offspring health in gestational diabetes mellitus (GDM) and T2DM. MF treatment is demonstrated to improve the efficiency of in vitro fertilization and is considered a supplementary drug in assisted reproductive technologies. MF administration shows positive effect on steroidogenesis and spermatogenesis in men with metabolic disorders, thus MF treatment indicates prospective use for improvement of male reproductive functions and fertility. MF lacks teratogenic effects and has positive health effect in newborns. The review is focused on use of MF therapy for restoration of female and male reproductive functions and improvement of pregnancy outcomes in metabolic and endocrine disorders. The mechanisms of MF action are discussed, including normalization of metabolic and hormonal status in PCOS, GDM, T2DM and metabolic syndrome and restoration of functional activity and hormonal regulation of the gonadal axis.

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Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase

Cited by 34 publications

References 43 publications

Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism

Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism

Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome

Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms

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