Baghdadite/Polycaprolactone nanocomposite scaffolds: preparation, characterisation, and in vitro biological responses of human osteoblast-like cells (Saos-2 cell line)

Arefpour, Ahmadreza; Kasiri‐Asgarani, Masoud; Monshi, Ahmad; Karbasi, Saeed; Doostmohammadi, Ali

doi:10.1080/10667857.2019.1692161

Cited by 17 publications

(9 citation statements)

References 37 publications

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“…Recently, BAG has been the focus of many academic researchers and has been extensively studied in porous frameworks, coatings, bone cement and void fillers, microspheres and nanoparticles (NPs), orthopaedic, dental and maxillofacial usages 11 , 17 , 18 . Arefpour et al 19 fabricated and investigated the laboratory method of BAG bioceramic nanoparticles (Ca 3 ZrSi 2 O 9 ) for clinical uses. NPs were examined by X-ray diffraction, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, distribution of particles size via laser beam scatter method, Fourier transforms infrared spectroscopy, and transmission electron microscopy.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The numerical study of pressure and temperature effects on mechanical properties of baghdadite-based nanostructure: molecular dynamics simulation

Bykanova

Akhmadeev

et al. 2022

Sci Rep

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Bioceramics have been commonly implemented to replace and restore hard tissues such as teeth and bones in recent years. Among different bioceramics, Baghdadite (BAG) has high bioactivity due to its ability to form apatite and stimulate cell proliferation. So, this structure is used widely for medical applications to treat bone-based diseases. Physically, we expect changes in temperature and pressure to affect the Baghdadite-based nanostructure’s mechanical behaviour. So, in this computational study, we report the pressure/temperature effect on Baghdadite matrix with nanoscale size by using Molecular Dynamics (MD) approach. To this end, physical values like the total energy, temperature, final strength (FS), stress–strain curve, potential energy, and Young’s modulus (YM) are reported. Simulation results indicated the mechanical properties of Baghdadite (BAG) nanostructure weakened by temperature and pressure increase. Numerically, the FS and YM of the defined structure reach 131.40 MPa/159.43 MPa, and 115.15 MPa/139.72 MPa with temperature/pressure increasing. Therefore, the increase in initial pressure and temperature leads to a decrease in the mechanical properties of nanostructures. These results indicate the importance of the initial condition in the Baghdadite-based nanostructures’ mechanical behaviour that must be considered in clinical applications.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The numerical study of pressure and temperature effects on mechanical properties of baghdadite-based nanostructure: molecular dynamics simulation

Bykanova

Akhmadeev

et al. 2022

Sci Rep

Self Cite

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“…As a result of its exceptional biological properties, baghdadite ceramic (as filler, matrix, and coating) is at the center of extensive research in the biomedical materials field. This ceramic has shown an emerging area of biocomposite materials research due to its remarkable properties [ 27 , 30 , 38 , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] ]. The following sections will discuss the latest biomedical applications of baghdadite ceramics, the process of bioactivity mechanisms, and their behavior in vitro and in vivo conditions.…”

Section: Pure Baghdadite Ceramicmentioning

confidence: 99%

“… - - - [ 9 ] PCL/Gr/Bagh P19 embryonal carcinoma cells PCL-1Gr-5Bagh scaffold caused further adhesion, viability, and proliferation of the cells, good proliferation of human fibroblast cells on PCL-1Gr-3Bagh and PCL-1Gr-5Bagh nanocomposite scaffolds - - - [ 104 ] PEI/PSS/Bagh/Ag MC3T3-E1 pre-osteoblast dramatically upregulating self-assembly of osteo differentiation markers, including ALP, collagen secretion, and Ca deposition by using baghdadite, promoting ALP expression and ECM (osteogenesis) by releasing Ca, Si and Zn ions, catechol and amine groups of PDA and PEI can exert beneficial osteogenic effects by serving as active recruiting sites of mineral ions and aid in apatite nucleation and growth. - - self-antibacterial coating against Staphylococcus aureus adhesion [ 105 ] Bagh/PCL Saos-2 cells line No cytotoxicity, good attachment and proliferation of cells on the both coated Bagh and Bagh/PCL scaffolds, less cell viability for scaffold with PCL coating in comparison to uncoated Bagh - - - [ 54 ] Bagh/Dio/PCLF Bone marrow stem cells (BMSc) Good attachment, high proliferation, and spreading of the BMSc cells on the surface of Bagh/Dio/PCLF scaffold, good biocompatibility, no toxicity - - - [ 27 ] N6/Bagh MG63 cells Increasing cellular activity, and cell viability, better cell attachment and spreading by increasing the amount of Bagh in composite scaffold in comparison to N6 - - - [ 106 ] PLA/Bagh/Alginate/Fe 3 O 4 - Sample including 20 wt% baghdadite has less toxicity than other samples - - - [ 69 ] Bagh/CN coating Human bone marrow mesenchymal stem cells Enhancing growth, proliferation, adhesion, and viability, activation of Zr ions on the differentiation of cells, bone formation and repair capability - …”

Section: Applications Of Baghdadite Ceramicmentioning

confidence: 99%

“…Biomaterial implants such as metals and ceramics can be coated with ceramic or composite coatings made from baghdadite ceramic [ 54 , 100 , 101 ]. Liang et al.…”

Section: Applications Of Baghdadite Ceramicmentioning

confidence: 99%

“…Another study conducted by Bakhsheshirad et al. [ 54 ] examined the antibacterial activities and corrosion resistance of a coated magnesium (Mg) alloy made from zinc oxide combined with baghdadite by physical vapor deposition (PVD) and electrophoretic deposition (EPD). The ZnO-coated Mg alloy samples and the naked sample in simulated bodily fluid solution, the ZnO/Ca 3 ZrSi 2 O 9 -coated specimen exhibited excellent corrosion resistance.…”

Section: Applications Of Baghdadite Ceramicmentioning

confidence: 99%

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Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review)

Sadeghzade

Liu²,

Wang³

et al. 2022

Materials Today Bio

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A comparison between β‐tricalcium phosphate and chitosanpoly‐caprolactone‐based3Dmelt extruded composite scaffolds

et al. 2021

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Melt extrusion 3D printing has become an attractive additive manufacturing technology to construct degradable scaffolds as tissue precursors in order to create clinically relevant medical devices. Towards this end, a commonly used synthetic polyester, poly‐caprolactone (PCL), was used to make scaffolds composed of different biomaterial compositions to increase bioactivity using 3D melt pneumatic extrusion technology. Varying ratios of the natural biopolymer, chitosan, or the bioceramic, β‐tricalcium phosphate (TCP) were blended with PCL to fabricate support scaffolds with three‐dimensional (3D) architecture for human bone‐marrow derived mesenchymal stem cell (hBMSC) growth for potential bone regeneration application. In this study, basic printing requirements as well as biomaterial dynamic mechanical (DMA), elemental, and thermogravimetric (TGA) analysis results demonstrate material homogeneity as well as thermal stability. Scaffold morphology and microarchitecture were assessed using scanning electron microscopy (SEM) alongside in vitro scaffold degradation and biological characterisation. Human BMSC proliferation was assessed using fluorescence imaging, and quantitated via the 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide (MTT) colorimetric assay. These in vitro cell viability studies revealed that the highest chitosan concentration blend of 20% favoured the most hBMSC growth, exhibited the most swelling, and showed minimal degradation after 28 days. The 20% TCP blend had the second highest hBMSC growth, exhibited moderate swelling, and the fastest degradation rate. Overall, this study demonstrates the first direct comparison of a natural biopolymer‐based, that is, chitosan, 3D melt extruded PCL composite with that of a bioceramic‐based, that is, β‐TCP, PCL composite and their effects on hBMSC 3D proliferation. 3D melt extruded PCL‐based composite scaffolds methodology offers a straightforward way to print scaffolds with good shape fidelity, interconnected porosities and enhanced bioactivity; and demonstrates their potential use for regenerative, bone repair applications.

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Baghdadite/Polycaprolactone nanocomposite scaffolds: preparation, characterisation, and in vitro biological responses of human osteoblast-like cells (Saos-2 cell line)

Cited by 17 publications

References 37 publications

RETRACTED ARTICLE: The numerical study of pressure and temperature effects on mechanical properties of baghdadite-based nanostructure: molecular dynamics simulation

RETRACTED ARTICLE: The numerical study of pressure and temperature effects on mechanical properties of baghdadite-based nanostructure: molecular dynamics simulation

Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review)

A comparison between β‐tricalcium phosphate and chitosanpoly‐caprolactone‐based3Dmelt extruded composite scaffolds

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