Bade-PUVA-Therapie bei Granuloma anulare

Salomon, N. S.; Walchner, Monika; Messer, Gerald; Plewig, Gerd; Röcken, Martin

doi:10.1007/s001050050901

Cited by 26 publications

(18 citation statements)

References 13 publications

(15 reference statements)

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“…Nach durch schnitt lich 55 Be hand lun gen (durch schnitt li che ku mu la ti ve UVA-Do sis: 69,5 J/cm 2 ) wa ren die Lä sio nen bei 5 Pa ti enten voll stän dig und bei 10 wei te ren weit ge hend ab ge heilt; 3 Pa ti en ten, da run ter ei ner mit lo ka li sier ter Form der Er kran kung, bra chen die The ra pie früh zei tig ab. Bei 4 der Re sponder kam es nach The ra pie en de zu ei nem Re zi div, nach er neu ter The ra pie wie der zu einer kli ni schen Ab hei lung [23].…”

Section: Pho To Che Mo the Ra Pieunclassified

Granuloma anulare

Kowalzick

2005

Hautarzt

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Granuloma annulare is a benign self-limiting disease of unknown origin, characterized by dermal papules tending to form annular shapes. It belongs to the granulomatous inflammatory skin diseases characterized by histomorphologically detectable granulomas. In addition to localized variants, generalized or disseminated variants also exist. The disease is often asymptomatic and does not require therapy in every case. Established therapies for localized forms of granuloma annulare are glucocorticosteroids, cream PUVA and cryosurgery. Antimalarials, antileprotics, retinoids, fumarates, UVA1 phototherapy and photochemotherapy are of value in disseminated cases. Recent case reports demonstrate the successful treatment of granuloma annulare with topical calcineurin antagonists or imiquimod and with the systemic administration of biologicals.

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Section: Pho To Che Mo the Ra Pieunclassified

Granuloma anulare

Kowalzick

2005

Hautarzt

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“…Bath-water PUVA with 8-MOP has been shown to be beneficial for many skin disorders: psoriasis (12), granuloma anulare (13), atopic dermatitis (14), lichen planus (15), lichen sclerosus et atrophicans (16), localized scleroderma (17), chronic palmoplantar eczema (18,19) and lymphomatoid papulosis (20). Comparative studies in psoriasis showed that bath-water PUVA is as effective as oral PUVA but requires less cumulative UVA (12,21,22).…”

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confidence: 97%

Bath‐water PUVA Therapy with 8‐Methoxypsoralen in Mycosis Fungoides

Weber¹,

Schmuth²,

Sepp³

et al. 2005

Acta Dermato-Venereologica

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PUVA therapy is widely used for early stage mycosis fungoides. While the efficacy of PUVA with oral 8-methoxypsoralen (8-MOP) is well documented, the use of its topical variation, bath-water PUVA therapy with 8-MOP has not been studied. The purpose of this study was to assess the effect of 8-MOP bath-water PUVA therapy in adult patients with early stage mycosis fungoides. We retrospectively evaluated the outcomes of bath-water delivery of 8-MOP (1 mg l(-1)) in 16 patients with early stage mycosis fungoides. In all patients complete response was achieved after a mean duration of 63 days requiring 29 treatments and a mean cumulative UVA dose of 33 J cm(-2). The time to relapse after complete clinical clearance was 45.6 (+/-9.2) weeks. In comparison, oral PUVA therapy with 8-MOP resulted in complete response after 64.5 days (25.8 treatments) with a mean relapse-free period of 30 (+/-3.5) weeks. We conclude that bath-water PUVA therapy with 8-MOP is a valuable photo-therapeutic alternative, which should be considered for patients in whom systemic psoralen cannot be used.

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“…Similar risks are faced with bath PUVA therapy or phototherapy with UVA1, the two methods used successfully to combat this disorder. 2–3 …”

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confidence: 99%