Bacteriophage in-feed application: A novel approach to preventing Salmonella Enteritidis colonization in chicks fed experimentally contaminated feed

Kimminau, E.A.; Russo, Katia; Karnezos, T.P.; Oh, Hyun-Jung; Lee, J.J.; Tate, C.C.; Baxter, James A.; Berghaus, Roy D.; Hofacre, Charles L.

doi:10.1016/j.japr.2020.09.003

Cited by 11 publications

(3 citation statements)

References 39 publications

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“…The inoculation bacteriophage cocktail made from phages isolated from chickens (UAB_Phi20, UAB_Phi87) and pigs (UAB_Phi78) decreased the Salmonella load in the cecum and mortality rate of white leghorn birds challenged with S. Typhimurium [178]. The administration of CTCBIO phage significantly reduced the S. Enteritidis load in the cloacal swab, liver, and spleen in broilers that are challenged with S. Enteritidis [179]. Broad-host-range phage (STP4-a) is beneficial over specific phages since they can inhibit multiple serovars of Salmonella with their polyvalent adsorption sites [180].…”

Section: Bacteriophagesmentioning

confidence: 99%

Salmonella Infection in Poultry: A Review on the Pathogen and Control Strategies

Shaji,

Selvaraj,

Shanmugasundaram

2023

Microorganisms

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Salmonella is the leading cause of food-borne zoonotic disease worldwide. Non-typhoidal Salmonella serotypes are the primary etiological agents associated with salmonellosis in poultry. Contaminated poultry eggs and meat products are the major sources of human Salmonella infection. Horizontal and vertical transmission are the primary routes of infection in chickens. The principal virulence genes linked to Salmonella pathogenesis in poultry are located in Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2). Cell-mediated and humoral immune responses are involved in the defense against Salmonella invasion in poultry. Vaccination of chickens and supplementation of feed additives like prebiotics, probiotics, postbiotics, synbiotics, and bacteriophages are currently being used to mitigate the Salmonella load in poultry. Despite the existence of various control measures, there is still a need for a broad, safe, and well-defined strategy that can confer long-term protection from Salmonella in poultry flocks. This review examines the current knowledge on the etiology, transmission, cell wall structure, nomenclature, pathogenesis, immune response, and efficacy of preventative approaches to Salmonella.

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Section: Bacteriophagesmentioning

confidence: 99%

Salmonella Infection in Poultry: A Review on the Pathogen and Control Strategies

Shaji,

Selvaraj,

Shanmugasundaram

2023

Microorganisms

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“…In the poultry industry, bacteriophages have also been used in a wide variety of applications, such as treating live birds, adding to poultry products, and disinfecting processing equipment. It was shown that treatment with phages administered to chickens via aerosol or oral gavage was able to control bacterial infections and decrease mortality [ 17 ]. Recent studies have reported success in reducing Salmonella spp.…”

Section: Introductionmentioning

confidence: 99%

An Edible Biopolymeric Microcapsular Wrapping Integrating Lytic Bacteriophage Particles for Salmonella enterica: Potential for Integration into Poultry Feed

et al. 2023

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This research work aimed at developing an edible biopolymeric microcapsular wrapping (EBMW) integrating lytic bacteriophage particles for Salmonella enterica, with potential application in poultry feed for biocontrol of that pathogen. This pathogen is known as one of the main microorganisms responsible for contamination in the food industry and in foodstuff. The current techniques for decontamination and pathogen control in the food industry can be very expensive, not very selective, and even outdated, such as the use of broad-spectrum antibiotics that end up selecting resistant bacteria. Hence, there is a need for new technologies for pathogen biocontrol. In this context, bacteriophage-based biocontrol appears as a potential alternative. As a cocktail, both phages were able to significantly reduce the bacterial load after 12 h of treatment, at either multiplicity of infection (MOI) 1 and 10, by 84.3% and 87.6%, respectively. Entrapment of the phage virions within the EBMW matrix did not exert any deleterious effect upon their lytic activity. The results obtained showed high promise for integration in poultry feed aiming at controlling Salmonella enterica, since the edible biopolymeric microcapsular wrapping integrating lytic bacteriophage particles developed was successful in maintaining lytic phage viability while fully stabilizing the phage particles.

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“…BP has been used in a wide variety of applications such as in the treatment of live birds, poultry products, and processing equipment ( Joerger, 2003 ). Previous research has demonstrated in chickens the efficacy of an in-feed bacteriophage for reducing the prevalence of Salmonella ( Kimminau et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Research Note: In-feed Bacteriophage does not impact efficacy of live Salmonella vaccine

Kimminau¹,

Karnezos²,

Russo³

et al. 2022

Poultry Science

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Bacteriophage in-feed application: A novel approach to preventing Salmonella Enteritidis colonization in chicks fed experimentally contaminated feed

Cited by 11 publications

References 39 publications

Salmonella Infection in Poultry: A Review on the Pathogen and Control Strategies

Salmonella Infection in Poultry: A Review on the Pathogen and Control Strategies

An Edible Biopolymeric Microcapsular Wrapping Integrating Lytic Bacteriophage Particles for Salmonella enterica: Potential for Integration into Poultry Feed

Research Note: In-feed Bacteriophage does not impact efficacy of live Salmonella vaccine

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