Bacteriophage Applications - Historical Perspective and Future Potential

Nicastro, Jessica; Wong, Stephanie E.; Khazaei, Zahra; Lam, Peggy; Blay, Jonathan; Slavcev, Roderick A.

doi:10.1007/978-3-319-45791-8

Cited by 7 publications

(8 citation statements)

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“…Since the beginning of the 19th century, phages have been studied as both biological entities and as molecular models. The period between the end of the 1930s and the beginning of the 1940s was the most important for research on these viruses [ 10 ]. In order to understand the infection process of bacterial viruses, Ellis and Delbruck proposed an experimental design, known as a one-step or single-step growth curve, to evaluate the infection cycle of phages [ 11 ].…”

Section: Bacteriophage Diversitymentioning

confidence: 99%

“…In the field of molecular biology, bacteriophages were of great importance in the experiments conducted by Benzer in 1955 using bacteriophage T4, through which the molecular concept of the gene was discovered [ 10 ]. The study of the phages also made it possible to identify the transduction process, decipher the genetic code, and discover the messenger RNA [ 12 ].…”

Section: Bacteriophage Diversitymentioning

confidence: 99%

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Phages in Anaerobic Systems

Hernández

Vives

2020

Viruses

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Since the discovery of phages in 1915, these viruses have been studied mostly in aerobic systems, or without considering the availability of oxygen as a variable that may affect the interaction between the virus and its host. However, with such great abundance of anaerobic environments on the planet, the effect that a lack of oxygen can have on the phage-bacteria relationship is an important consideration. There are few studies on obligate anaerobes that investigate the role of anoxia in causing infection. In the case of facultative anaerobes, it is a well-known fact that their shifting from an aerobic environment to an anaerobic one involves metabolic changes in the bacteria. As the phage infection process depends on the metabolic state of the host bacteria, these changes are also expected to affect the phage infection cycle. This review summarizes the available information on phages active on facultative and obligate anaerobes and discusses how anaerobiosis can be an important parameter in phage infection, especially among facultative anaerobes.

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Section: Bacteriophage Diversitymentioning

confidence: 99%

Section: Bacteriophage Diversitymentioning

confidence: 99%

Phages in Anaerobic Systems

Hernández

Vives

2020

Viruses

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“…Over the past 30 years, phages have proven to be geneticallymalleable tools [11][12][13][14][15] . New developments using genetic engineering (a.k.a.…”

Section: Genetically Modified Phagementioning

confidence: 99%

The future of phage clinical trials in Australia

Potent¹

2019

Microbiol. Aust.

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Australia is well positioned to conduct clinical trials in phage-based technology. Despite challenges with translating phage therapy to mainstream medicine, our regulations are designed for safe and innovative development. Recent success indicates that Australia is ideal for conducting further phage clinical trials. There are also expert clinical research organisations and generous tax incentives.

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“…They can be classified based on their morphology and the nature of their nucleic acids proposed by the International Committee on the Taxonomy of Viruses (ICTV) [9]. Generally, more than 96% of the bacteriophages are tailed (e.g., T-even phages), and the others are usually filamentous (e.g., M13 phages) and pleomorphic (able to assume different forms) [9][10][11]. After recognizing specific sites on the bacterium surface, phages can bind to their host cells by the specific receptor binding proteins (RBPs), inject DNA after depolymerization and cleavage of the bacterial outer structures and take over the host machinery to propagate new virions [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…After recognizing specific sites on the bacterium surface, phages can bind to their host cells by the specific receptor binding proteins (RBPs), inject DNA after depolymerization and cleavage of the bacterial outer structures and take over the host machinery to propagate new virions [12,13]. They can also be classified based on different infection and lytic cycles: one is called lytic phage that will lyse the bacteria immediately to infect the new host; the other is called lysogenic phage that will integrate their genome into the host DNA, remain dormant until stimulated for replication and propagation [1,10,14].…”

Section: Introductionmentioning

confidence: 99%

Phage-based Electrochemical Sensors: A Review

Chau

Lee

2019

Micromachines

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Phages based electrochemical sensors have received much attention due to their high specificity, sensitivity and simplicity. Phages or bacteriophages provide natural affinity to their host bacteria cells and can serve as the recognition element for electrochemical sensors. It can also act as a tool for bacteria infection and lysis followed by detection of the released cell contents, such as enzymes and ions. In addition, possible detection of the other desired targets, such as antibodies have been demonstrated with phage display techniques. In this paper, the recent development of phage-based electrochemical sensors has been reviewed in terms of the different immobilization protocols and electrochemical detection techniques.

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Bacteriophage Applications - Historical Perspective and Future Potential

Cited by 7 publications

References 0 publications

Phages in Anaerobic Systems

Phages in Anaerobic Systems

The future of phage clinical trials in Australia

Phage-based Electrochemical Sensors: A Review

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