Bacteriological trends and antibiotic susceptibility patterns of clinical isolates at Government Cancer Hospital, Marathwada

Nazneen, Suraiya; Mukta, K; Santosh, C; Borde, Aditi

doi:10.4103/ijc.ijc_34_17

Cited by 9 publications

(14 citation statements)

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“…(61.53%) was most commonly isolated followed by S. aureus (38.46 %). This was rather different from prevalence rates in most other studies done in cancer population where predominant Gram-positive organism was S. aureus 10,12,17 .…”

Section: Discussioncontrasting

confidence: 91%

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Microbial and Antibiotic Susceptibility Profile among Isolates of Clinical Samples of Cancer Patients admitted in the Intensive-care Unit at Regional Tertiary Care Cancer Center: A Retrospective Observational Study

Kumar¹,

Bhatnagar²,

Gupta³

et al. 2019

Indian Journal of Critical Care Medicine

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Cancer patients in intensive care unit (ICU) are vulnerable for developing multidrug resistant nosocomial infections. The antimicrobial resistance due to inappropriate use of antibiotics results in significant morbidity and mortality in these cancer patients. The present retrospective study was done to describe the antimicrobial sensitivity pattern of common organisms in isolates of clinical samples of patients admitted in ICU at our tertiary care cancer center. Materials and methods The study was carried out at ICU of a regional tertiary care cancer center for a period of 1 year from October 2016 to September 2017. All clinical samples were collected and processed for culture and antibiotic susceptibility testing were carried out on isolates as per Clinical Laboratory Standard Institute guidelines. Results A total of 644 specimens were collected. Escherichia coli, Acinetobacter spp., Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus spp. were most commonly encountered. In positive bacterial cultures, majority were Gram-negative isolates (84.14 %). Klebsiella was the most common gram-negative isolate (34.78%) and Enterococcus spp. were the most common Gram-positive isolates (61.53%). A high level of resistance to various antibiotics was noted among Gram-negative bacteria compared to Gram-positive isolates. Majority of the Gram-negative isolates were sensitive to Imipenem, Meropenem, and Colistin sensitivity among Gram-negative isolates was 100%. Linezolid, Teicoplanin and Vancomycin were most sensitive antimicrobials against the Gram-positive bacteria. Conclusion Regular monitoring of the pattern of resistance of bacteriological isolates in cancer patients is critical to develop antibiotic policy to combat these infections and reduce morbidity and mortality. How to cite this article Garg VK, Seema M et al . Microbial and Antibiotic Susceptibility Profile among Isolates of Clinical Samples of Cancer Patients admitted in the Intensive-care Unit at Regional Tertiary Care Cancer Center: A Retrospective Observational Study. Indian J of Crit Care Med 2019;23(2):67-72.

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Section: Discussioncontrasting

confidence: 91%

“…(8/82, 9.75%). Similar findings were also observed by Nazneen etal ., a study conducted at cancer centre at Aurangabad, Marathwada 12 . Among Gram-negative isolates, Klebsiella (34.78%) was the predominant organism followed by Pseudomonas (21.73%) in our study.…”

Section: Discussionmentioning

confidence: 99%

Microbial and Antibiotic Susceptibility Profile among Isolates of Clinical Samples of Cancer Patients admitted in the Intensive-care Unit at Regional Tertiary Care Cancer Center: A Retrospective Observational Study

Kumar¹,

Bhatnagar²,

Gupta³

et al. 2019

Indian Journal of Critical Care Medicine

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“…The highest numbers of isolates were obtained from the pus sample and the lowest from CSF. In a similar study carried out previously, 110 different organisms were isolated from a total of 170 clinical samples such as pus, urine blood, sputum, and drain fluid, and they reported 15.78% of isolates were P. aeruginosa and 57 (22.4%) isolates were isolated from 254 pus samples in a study carried out in Bathinda 21,22 . The occurrence of multidrugresistant Metallo-β-lactamase P. aeruginosa isolates in a hospital setting is of concern as it poses a problem in therapy and infection control management.…”

Section: Fig 1: Isolates Showing Resistance Towards Carbapenems Leftmentioning

confidence: 71%

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2020

IJPSR

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“…Various reports across India have documented variations in MRSA prevalence which ranges from 17.6% to 80.4% depending on the geographical area. [20][21][22][23][24] Similarly, the survey identified 34% of the delegates who observed 10-20% of MRSA prevalence; while, another 30% delegates identified 20%-40% of MRSA in their respective ICU settings. This variation in prevalence rates could be attributed to the different ICU settings, patient profiles and local antibiotic regimen that could impact the overall prevalence.…”

Section: Discussionmentioning

confidence: 99%

Current clinical trends in the management of gram positive infections in Indian critical care settings: a survey

Rampal¹,

Ahdal²,

Kaushik³

et al. 2019

Int J Res Med Sci

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Background: In India, gram-positive infections (GPIs) particularly, methicillin-resistant Staphylococcus aureus (MRSA) prevalence is reported to increase exponentially. The overall mortality rate among patients with multi drug resistant GPIs in ICU setting are as high as 16%, despite the availability of various therapeutic options. Aim of the study is to determine the burden of GPIs in critical care settings and to understand the practising behaviour among the specialists in the management of MRSA infections.Methods: The survey was conducted among 264 critical care specialists who attended the Annual National Conference of Indian Society of Critical Medicine held in February 2019 at Mumbai. The delegates were administered a validated 10 question survey.Results: In the survey, 72% of the respondents agreed to the rising prevalence of MRSA and associated increased mortality rate of >16%. Empirical gram positive cover is being given to 30-40% of ICU patients, with ABSSSI being listed as a major indication followed by CAP, VAP, CLABSI and DFI. 46% of the doctors listed vancomycin as their preferred anti-MRSA agents followed by teicolplanin and linezolid. However, more than 80% of the doctors feel that nephrotoxicity in vancomycin, thrombocytopenia in linezolid and poor biofilm penetration are major limitations of these anti-MRSA agents.Conclusions: The survey highlighted the increasing trend in the prevalence and associated mortality in GPIs in critical care settings in India. Further, the limitations of existing anti-MRSA agents have invoked the need for a newer agent with a broad spectrum anti-bacterial activity along with improved safety profile and effective biofilm penetration, which can be used as a suitable alternative empiric therapy to manage GPIs.

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Bacteriological trends and antibiotic susceptibility patterns of clinical isolates at Government Cancer Hospital, Marathwada

Abstract: The present study reveals microbiological profile in patients attending our hospital. Regular surveillance helps in implementing better therapeutic strategies to reduce morbidity and mortality associated in patients in health-care facility.

Cited by 9 publications

References 1 publication

Microbial and Antibiotic Susceptibility Profile among Isolates of Clinical Samples of Cancer Patients admitted in the Intensive-care Unit at Regional Tertiary Care Cancer Center: A Retrospective Observational Study

Microbial and Antibiotic Susceptibility Profile among Isolates of Clinical Samples of Cancer Patients admitted in the Intensive-care Unit at Regional Tertiary Care Cancer Center: A Retrospective Observational Study

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Current clinical trends in the management of gram positive infections in Indian critical care settings: a survey

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