Bacteriological Profile of Urinary Tract Infection of Children at GMC Teaching Hospital

Abstract

This study aimed to find bacterial profile of urinary tract infection (UTI) in children between 2 months to 15 years of age. This is a hospital based retrospective study conducted at Gandaki medical college and teaching hospital, Pokhara over a period of 18 months. Among the total 575 children enrolled for the study, 110 children (19.1%) were found to be culture positive. Most common age group having culture positivity is 1-5 years (40%). Present study showed that UTI is more common in girls (69.1%) than in boys (30.9%). E. coli was still the most commonly isolated bacteria (70.9%) followed by Proteus (20%), Klebsiella (5.4%) and Pseudomonas sp. in (1.8%). E. coli was sensitive to Nitrofurantoin (84.6 %), Amikacin (80.7%), Gentamicin (73%) and Ofloxacin in (53.8%). Most commonly used drugs for the treatment of UTI like Cefixime and Ceftriaxone was sensitive only in 15% and 10% respectively. Similarly, Klebsiella was sensitive to Amikacin and Gentamicin (100%) but sensitive to Nitrofurantoin in only 66% of cases. Proteus was sensitive to Nitrofurantoin (95.4%), Amikacin (86%) and to Gentamicin (59%). High resistance rate was observed to Cefixime and Ceftriaxone, the commonly used drugs for its treatment in OPD basis. DOI: http://dx.doi.org/10.3126/jcmc.v3i3.8633 Journal of Chitwan Medical College 2013; 3(3): 22-25

Bacteriological Profile of Urinary Tract Infection in Children of a Tertiary Care Hospital

“…This is in complete agreement to the findings in two studies done in Nepal and another Bangladeshi study. 2,9,22 This was less than the finding observed by GK Rai et al (93.3%) among children of Nepal. 21 In different studies, the percentage of Escherichia coli (E. coli) was different ranging from 30.2% to 90% in collected urine samples.…”

“…21 In different studies, the percentage of Escherichia coli (E. coli) was different ranging from 30.2% to 90% in collected urine samples. 2,10,11,12 In this study, E. coli was followed by Enterococcus (19.2%), Klebsiella (10.2%) and others as shown in Table 3. This is in close agreement with a previous study reported by Ladhini and Grandsen.…”

“…The predominance of females in this study is consistent with many previous reports. 2,15,19,20 The reason of this disease being more common in female child is probably short urethra in female besides others factors. But this result is not consistent with the study done by Rekha et al and GK Rai et al where UTI was more prevalent in male children (53.3%).…”

“…3 Although the outcome of UTI is usually benign, symptomatic UTI is associated with renal parenchymal involvement which predisposes to renal scarring with devastating consequences such as hypertension, CRF and ESRD. 2,4 Prompt diagnosis and early initiation of appropriate antibiotics in children reduce the morbidities associated with UTI. In suspected UTI cases, it is appropriate to begin empiric treatment after collecting urine specimens for culture and sensitivity.…”

“…It affects male children more than female in the first year of life and mostly female after 1 year of age. 2 In 2007, a meta analysis was carried out where the overall prevalence of UTI was 7.0% among infants presenting with fever. 3 Although the outcome of UTI is usually benign, symptomatic UTI is associated with renal parenchymal involvement which predisposes to renal scarring with devastating consequences such as hypertension, CRF and ESRD.…”