“…Streptococcus pyogenes used to be the most common pathogen in AOM in the beginning of 20th century, but became less frequent after 1950, as SP became more widespread and the most common pathogen in AOM [9,10] In FinOM cohort study in 1995-1997, the incidence of the three most common pathogens were nearly equal, SP 26%, MC 23% and HI 23%, coagulase-negative Staphylococcus aureus being the most common pathogen (38%) [4]. Another study from the late 1990s showed that SP was the most common (49%) pathogen in children with tympanostomy tubes followed by HI 29% and MC 28% [3].…”