Bactericidal permeability increasing protein gene variants in children with sepsis

Michálek, Jaroslav; Svetlikova, Petra; Fedora, Michal; Klimovič, Michal; Klapačová, Lenka; Bartošová, Drahomíra; Elbl, Lubomı́r; Hrstková, Hana; Hubacek, Jaroslav A.

doi:10.1007/s00134-007-0860-3

Cited by 36 publications

(32 citation statements)

References 31 publications

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“…Haplotype analysis of rs2234237and rs2234246 in patients with septic shock and control subjects and in the survivors and non-survivors clinical course of severe sepsis. [16][17][18][19][20] It is anticipated that these fi ndings will lead to the use of new diagnostic markers, prognostic indicators, and therapeutic strategies for sepsis. [29] In this study, two common SNPs in the TREM-1 gene were evaluated with regard to the susceptibility and prognosis of septic shock.…”

Section: Discussionmentioning

confidence: 99%

“…Studies [16][17][18][19][20] confirmed that single nucleotide polymorphisms (SNPs) in some particular genes, such as interleukin-6 gene polymorphisms G-174>C and G-572>C, bactericidal permeability increasing protein (BPI) (G545>C) Taq and BPI (A645>G) 216, β-defensin 1 variant haplotype -20G/-44G/-52G, IRAK-1 variant haplotype, protein C-1641 AA genotype, etc, play a critical role in severe sepsis or septic shock.…”

Section: Introductionmentioning

confidence: 99%

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Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and septic shock in a Chinese Han population

Peng¹,

Li²,

Zhou³

et al. 2015

World Journal of Emergency Medicine

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BACKGROUND: Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell surface receptor expressed on neutrophils and monocytes. TREM-1 acts to amplify infl ammation and serves as a critical mediator of infl ammatory response in the context of sepsis. To date, the predisposition of TREM-1 gene polymorphisms to septic shock has not been reported. This study was designed to investigate whether TREM-1 genomic variations are associated with the development of septic shock. METHODS:We genotyped two TREM-1 single nucleotide polymorphisms (SNPs, rs2234237 and rs2234246) and evaluated the relationships between these SNPs and septic shock on susceptibility and prognosis.RESULTS: TREM-1 rs2234246 A allele in the promoter region was signifi cantly associated with the susceptibility of septic shock in recessive model (AA, OR=3.10, 95%CI 1.15 to 8.32, P=0.02), and in codominant model (AG, OR=0.72, 95%CI 0.43-1.19, P=0.02; AA, OR=2.71, 95%CI 1.00-7.42; P=0.03). However, in three inherited models (dominant model, recessive model, and codominant model), none of the assayed loci was signifi cantly associated with the prognosis of septic shock. The nonsurvivor group demonstrated higher plasma IL-6 levels (99.7±34.7 pg/mL vs. 61.2±26.5 pg/mL, P<0.01) than the survivor group. Plasma concentrations of IL-6 among the three genotypes of rs2234246 were AA 99.4±48.9 pg/mL, AG 85.4±43 pg/mL, and GG 65.3±30.7 pg/mL (P<0.01). The plasma concentrations of IL-6 in patients with AA genotypes were signifi cantly higher than those in patients with GG genotypes (P<0.01).CONCLUSION: TREM-1 genetic polymorphisms rs2234246 may be significantly correlated only with susceptibility to septic shock in the Chinese Han population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and septic shock in a Chinese Han population

Peng¹,

Li²,

Zhou³

et al. 2015

World Journal of Emergency Medicine

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“…In particular, SNPs in the genes participating in the pathophysiologic process of sepsis may contribute to the susceptibility to and outcome of sepsis [19,20]. Recent studies have identified that IL-6 Ϫ174G/C and Ϫ572G/C, bactericidal permeability increasing (BPI) protein gene Taq polymorphism, human ␤-defensin 1 gene (DEFB1) Ϫ44G/C, and protein C Ϫ1641AA genotype, as well as IL-1 receptor-associated kinase (IRAK-1) haplotype, were associated with the clinical course of severe sepsis [21][22][23][24][25]. It is anticipated that these findings will lead to new diagnostic markers and prognostic indicators as well as therapeutic strategies for sepsis [20].…”

Section: Discussionmentioning

confidence: 99%

Lack of association between TREM-1 gene polymorphisms and severe sepsis in a Chinese Han population

Chen¹,

Zhou²,

Wu³

et al. 2008

Human Immunology

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“…Sepsis is a complex disease resulting from the interactions between environmental factors and genetic factors (Cohen 2002;Stuber 2001). It has been anticipated that single nucleotide polymorphisms (SNPs) in genes participating in pathophysiologic process of sepsis may contribute to the susceptibility to sepsis and the outcome of sepsis (Arcaroli et al 2006;Chen et al 2007;Cobb and O'Keefe 2004;Lin and Albertson 2004;Michalek et al 2007;Pinsky 2007;Stuber 2001;Walley and Russell 2007), and genetic study in sepsis will lead to new diagnostic markers and prognostic indicators as well as therapeutic strategies for sepsis (Cobb and O'Keefe 2004).…”

Section: Introductionmentioning

confidence: 99%

Protein C -1641A/-1654C haplotype is associated with organ dysfunction and the fatal outcome of severe sepsis in Chinese Han population

Chen

Wang

et al. 2008

Hum Genet

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Activation of protein C plays an important role in modulating coagulation as well as inflammation during severe sepsis. The baseline of activated protein C level in patients with severe sepsis showed interindividual variability between survivors and nonsurvivors, and the decreased level of protein C correlated with organ dysfunction and poor outcome. However, there are limited data concerning the genetic predisposition of individuals carrying two functional polymorphisms -1641A>G and -1654C>T within protein C gene to sepsis. Here we investigated the impact of these two variations on the development of severe sepsis in 240 patients with severe sepsis and 323 healthy controls using direct sequencing. After Bonferroni correction for multiple comparisons, -1641A/-1654C haplotype was significantly associated with the fatal outcome of severe sepsis (P = 0.008, OR 1.739, 95% CI 1.165-2.595), which was confirmed by multiple logistic regression analysis (P = 0.024, OR 2.090, 95% CI 1.101-3.967). Compared to patients without carrying -1641A/-1654C haplotype, the -1641A/-1654C haplotype carriers showed higher SOFAmax scores (10.3 +/- 5.2 vs. 9.0 +/- 4.5; P = 0.014) and more hepatic dysfunction (P = 0.004, OR 2.270, 95% CI 1.312-3.930). These findings suggest that protein C haplotype -1641A/-1654C is associated with organ dysfunction and is an independent risk factor for the fatal outcome of severe sepsis in Chinese Han population.

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Bactericidal permeability increasing protein gene variants in children with sepsis

Abstract: BPI Taq gene polymorphism is the accurate predictor of the severity of sepsis in children admitted to the PICU.

Cited by 36 publications

References 31 publications

Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and septic shock in a Chinese Han population

Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and septic shock in a Chinese Han population

Lack of association between TREM-1 gene polymorphisms and severe sepsis in a Chinese Han population

Protein C -1641A/-1654C haplotype is associated with organ dysfunction and the fatal outcome of severe sepsis in Chinese Han population

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