Bactericidal and cytotoxic effects of Erythrina fusca leaves aquadest extract

Sudiono, Janti; Sandra, Ferry; Halim, Nadya Saputri; Kadrianto, Timotius Andi; Melinia, Melinia

doi:10.20473/j.djmkg.v46.i1.p9-13

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…The potential of ecofriendly AgNPs of present study to inhibit periodontal disease-causing microorganisms is also supported by other studies, which suggest that plant extract blended AgNPs have potential to inhibit periodontal disease-causing microorganisms [61]. Research evidences accounts E. fusca leaves to possess alkaloids, tannins, triterpenoids, glycosides, saponins, and steroids [19]. Hence, as per literary evidences and antimicrobial results of present study, it can be postulated that biochemical moieties of EFLAE (possibly alkaloids and triterpenoids) caused capping of silver and lead to marked increase in antimicrobial potential of AgNPs against periodontitis causing pathogenic microflora.…”

Section: Discussionsupporting

confidence: 82%

“…There is high occurrence of P. aeruginosa, E. coli, S. pyogenes, and B. cereus in periodontal site of chronic patients of periodontitis [18]. Studies consider periodontal disease as the most oral infectious disease that is predominated by microorganism [19].…”

Section: Introductionmentioning

confidence: 99%

“…The traditional herb Erythrina fusca commonly eaten as vegetable is known to possess alkaloid, glycoside, saponin, tannin, triterpenoid, and steroid as chief constituents. The high efficacy of E. Fusca in periodontitis always draws investigators attention [19].…”

Section: Introductionmentioning

confidence: 99%

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Response of green synthesized drug blended silver nanoparticles against periodontal disease triggering pathogenic microbiota

2019

Jabb

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Objective: Evidences for microorganisms to predominate periodontal disease, alteration of human pathogen shifted microbiota by Erythrina fusca, and antimicrobial response potentiation by ecofriendly silver nanoparticles (AgNPs) intended present study to perform green synthesis of AgNPs and evaluate against periodontal disease triggering pathogenic microbiota. Material and Methods: Present study involved green synthesis of AgNPs using Erythrina fusca leaves aqueous extract (EFLAE), followed by optimization, characterization, stability, and evaluation of antimicrobial potential of biosynthetic AgNPs against periodontitis causing pathogenic human microflora (Pseudomonas aeruginosa, Escherichia coli, Streptococcus pyogenes, and Staphylococcus aureus). Results: The AgNPs green synthesis success was based on brown coloration and surface plasmon resonance signal at 433 nm. UV-Visible spectrometry driven optimization determined 5 mM AgNO 3 concentration, 1:9 EFLAE and AgNO 3 volumetric ratio, pH 7, 60°C temperature, and 2 hours' time as parametric requirements for AgNPs biosynthesis. Stability studies revealed signal appearance between 415 and 424 nm supporting AgNPs stability. Characterization studies recognized shifted and broadened Fourier transformed infrared bands of AgNPs revealing silver capping by biochemical moieties of EFLAE; AgNPs size below 32 nm in field emission scanning electron microscopic micrograph; X-ray diffraction signals at 38.95, 44.97, 64.92, and 78.97 representing 111, 200, 220, and 311 AgNPs silver cubic structure planes; and elemental silver 83.66%, carbon 11.87%, and oxygen 4.47% in energy-dispersive X-ray spectrum. Optimized and characterized biogenic AgNPs, when evaluated against periodontal disease-causing pathogenic microflora using well diffusion method, exhibited maximum inhibitory zone (in mm) against Bacillus cereus (13 and 18), followed by P. aeruginosa (11 and 19), E. coli (10 and 18), and S. pyogenes (9 and 15) in 50 and 100 µg/ml administered dose. Conclusion:Present study concludes that biogenic AgNPs synthesized using EFLAE possess high inhibition potential against periodontitis triggering pathogens (E. coli, B. cereus, S. pyogenes, and P. aeruginosa) of microbiota, and recommends EFLAE as potential source for AgNPs green synthesis.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Response of green synthesized drug blended silver nanoparticles against periodontal disease triggering pathogenic microbiota

2019

Jabb

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“…In the periodontal site of chronic patients, high distribution of B. cereus , S. pyogenes , P. aeruginosa , and E. coli commonly occurs [ 10 ]. Research has also suggested periodontal disease as the most common oral infectious disease that is predominated by microorganisms [ 11 ]. Also, bacterial resistance in biofilms to anti-microbial treatment can be up to 1,000 times greater than that of planktonic organisms [ 12 ] which presents a major global health problem [ 13 ] and causes tooth loss [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Copper Nano-Drug and Its Dental Application upon Periodontal Disease-Causing Microorganisms

El-Rab

Basha

Ashour

et al. 2021

J. Microbiol. Biotechnol.

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Dental pathogens lead to chronic diseases like periodontitis, which causes loss of teeth. Here, we examined the plausible antibacterial efficacy of copper nanoparticles (CuNPs) synthesized using Cupressus macrocarpa extract (CME) against periodontitis-causing bacteria. The antimicrobial properties of CME-CuNPs were then assessed against oral microbes (M. luteus. B. subtilis, P. aerioginosa) that cause periodontal disease and were identified using morphological/ biochemical analysis, and 16S-rRNA techniques. The CME-CuNPs were characterized, and accordingly, the peak found at 577 nm using UV-Vis spectrometer showed the formation of stable CME-CuNPs. Also, the results revealed the formation of spherical and oblong monodispersed CME-CuNPs with sizes ranged from 11.3 to 22.4 nm. The FTIR analysis suggested that the CME contains reducing agents that consequently had a role in Cu reduction and CME-CuNP formation. Furthermore, the CME-CuNPs exhibited potent antimicrobial efficacy against different isolates which was superior to the reported values in literature. The antibacterial efficacy of CME-CuNPs on oral bacteria was compared to the synergistic solution of clindamycin with CME-CuNPs. The solution exhibited a superior capacity to prevent bacterial growth. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and fractional inhibitory concentration (FIC) of CME-CuNPs with clindamycin recorded against the selected periodontal disease-causing microorganisms were observed between the range of 2.6-3.6 μg/ml, 4-5 μg/ml and 0.312-0.5, respectively. Finally, the synergistic antimicrobial efficacy exhibited by CME-CuNPs with clindamycin against the tested strains could be useful for the future development of more effective treatments to control dental diseases.

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“…. Bactericidal effects had been reported in the leaves aquadest extract of the E. fusca [11]. Other than antibacterial effect, it is also effective against malaria parasites [12].…”

Section: Phaseolin (1)mentioning

confidence: 99%

Phytochemical, Biological and Computational Investigations of <em>Erythrina fusca</em> Lour. to Assess Antimalarial Property against <em>Plasmodium falciparum</em>

Sazed¹,

Islam²,

Bliese³

et al. 2020

Preprint

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For centuries medicinal plants have been traditionally used for prophylaxis and ailment of diseases. Nowadays it’s easy to isolate, purify, and characterize bioactive compounds with high efficacy. To investigate the medicinal especially antimalarial property of traditionally used plants, a number of Erythrina spp have been reviewed systematically where Erythrina fusca has been selected for further analysis. Phytochemical investigation included chromatographic separation and purification of compounds followed by characterization using NMR. In-vitro antimalarial drug sensitivity ELISA was carried out against chloroquine (CQ) sensitive 3D7 and resistant Dd2 strains. Additional biological tests such as central and peripheral analgesic, antioxidant, anti-diarrheal, hypoglycemic, thrombolytic, and membrane stabilization activities were also investigated. Molecular docking was performed using the isolated compounds against clinically important 14 Plasmodium falciparum proteins. For the first time, Phaseolin, Phytol, β-amyrin, Lupeol, and Stigmasterol are reported here and extracts showed significant antimalarial activity against 3D7 and Dd2 strains (IC50 4.94-22 µg/mL). Potent central analgesic, antioxidant and anti-diarrheal activities (p&lt;0.05) and mild thrombolytic and membrane stabilization properties were also observed. Molecular docking of Phaseolin bolsters its potential as a new antimalarial drug candidate. This study projects significant medicinal values and necessitates further investigations to reveal its potential as a novel source of therapeutics.

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Bactericidal and cytotoxic effects of Erythrina fusca leaves aquadest extract

Cited by 5 publications

References 13 publications

Response of green synthesized drug blended silver nanoparticles against periodontal disease triggering pathogenic microbiota

Response of green synthesized drug blended silver nanoparticles against periodontal disease triggering pathogenic microbiota

Green Synthesis of Copper Nano-Drug and Its Dental Application upon Periodontal Disease-Causing Microorganisms

Phytochemical, Biological and Computational Investigations of <em>Erythrina fusca</em> Lour. to Assess Antimalarial Property against <em>Plasmodium falciparum</em>

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