Bactericidal Activity of Skin Disinfectants on Methicillin-Resistant Staphylococcus aureus

Sakuragi, Tadakazu; Yanagisawa, Katsuyoshi; Dan, Kenjiro

doi:10.1213/00000539-199509000-00023

Cited by 20 publications

(25 citation statements)

References 16 publications

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“…This evidence included the significant decrease in overall contamination rates during the study compared to the baseline period, the significantly lower contamination rate for the combined alcohol-containing antiseptic groups compared to the combined PI groups (baseline period and PI study arm), and the absence of a significant difference between contamination rates when PI was used during the study and baseline periods despite significant differences between the baseline PI contamination rate and the rates observed for IPA and Persist. The apparent benefit of alcohol-containing antiseptics was likely due to their more rapid antimicrobial activity compared to iodophors (4,5,13 3% with PI and alcohol, respectively (P ϭ 0.39). The ability of that study to detect a significant difference between the two antiseptics was limited by a small sample size.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Four Antiseptic Preparations for Skin in the Prevention of Contamination of Percutaneously Drawn Blood Cultures: a Randomized Trial

Calfee

Farr

2002

J Clin Microbiol

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A number of skin antiseptics have been used to prevent the contamination of blood cultures, but the comparative efficacies of these agents have not been extensively evaluated. We therefore sought to compare the efficacy of four skin antiseptics in preventing blood culture contamination in a randomized, crossover, investigator-blinded study conducted in an emergency department and the inpatient wards of a university hospital. The patient group included all patients from whom blood samples were obtained percutaneously for culture. Skin antisepsis was performed with 10% povidone-iodine, 70% isopropyl alcohol, tincture of iodine, or povidone-iodine with 70% ethyl alcohol (i.e., Persist). The blood culture contamination rate associated with each antiseptic was then determined. A total of 333 (2.62%) of 12,692 blood cultures were contaminated during the study period compared to 413 (3.21%) of 12,859 blood cultures obtained during the previous 12-month period (relative risk ‫؍‬ 0.82; 95% confidence interval, 0.71 to 0.94; P ‫؍‬ 0.006). During the study, the contamination rates were determined to be 2.93% with povidone-iodine, 2.58% with tincture of iodine, 2.50% with isopropyl alcohol, and 2.46% with Persist (P ‫؍‬ 0.62). We detected no significant differences in the blood culture contamination rates among these four antiseptics, although there was some evidence suggesting greater efficacy among the alcohol-containing antiseptics. Among the evaluated antiseptics, isopropyl alcohol may be the optimal antiseptic for use prior to obtaining blood for culture, given its convenience, low cost, and tolerability.

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Section: Discussionmentioning

confidence: 99%

Comparison of Four Antiseptic Preparations for Skin in the Prevention of Contamination of Percutaneously Drawn Blood Cultures: a Randomized Trial

Calfee

Farr

2002

J Clin Microbiol

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“…Alcohols have excellent in vitro germicidal activity against gram-positive and gram-negative vegetative bacteria, including multidrug-resistant pathogens (e.g., MRSA and VRE), Mycobacterium tuberculosis, and various fungi (120)(121)(122)(124)(125)(126)(127)(128)(129). Certain enveloped (lipophilic) viruses (e.g., herpes simplex virus, human immunodeficiency virus [HIV], influenza virus, respiratory syncytial virus, and vaccinia virus) are susceptible to alcohols when tested in vitro (120,130,131) (Table 1).…”

Section: Alcoholsmentioning

confidence: 99%

The Effect of a Scenario based Hand Hygiene Education Program on Hand Hygiene Knowledge, Hand Hygiene Perception, Hand Hygiene Compliance and Hand Hygiene Method in Nursing Students<sup>*</sup>

Hwang¹,

Park²

2016

J Korean Acad Fundam Nurs

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“…This may affect the susceptibility of the tooth to acid attack. Povidone-iodine has been shown to be effective against most bacteria [Ivanovski et al, 1995;Sakuragi et al, 1995], fungi [White-Weithers and Medleau, 1995], viruses [Shimakoshi et al, 1995] as well as spores [Ross and Holbrook, 1984], but the effect of this chemical on enamel integrity is not known.…”

mentioning

confidence: 99%

Efficacy of Sterilisation Methods and Their Effect on Enamel Demineralisation

Amaechi

Higham

Edgar³

1998

Caries Res

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The aim of this project was to determine the effectiveness of sterilisation methods for dental enamel for use in intra–oral cariogenicity tests, and their possible effect on the degree of demineralisation of enamel. Bovine incisors were cut vertically into five portions and each assigned to one of five groups. Group 1 was used as a control while the other four groups were subjected, respectively, to gamma irradiation (≅25kGy), steam autoclaving (121°C for 15min), sodium hypochlorite (12% w/v for 24h) and povidone–iodine (7.5% w/v for 24h). Total viable counts of microorganisms remaining following sterilisation of the specimens were performed following incubation of the specimens for 24h at 37°C. Caries–like lesions were produced in each specimen using an acidic buffer solution (pH4.5). Sections were cut from each specimen, ground to 80–μm thickness, and microradiographed. Mineral loss and lesion depth were quantified using transverse microradiography. Statistical analysis was by ANOVA. Dunnett's and Tukey's tests. Microbial growth (Staphylococcus aureus and bacilli) was observed only in control specimens in both brain heart infusion broth and on blood agar plates. The sterilisation methods affected the enamel surface as follows: gamma irradiation (cream discolouration), NaOCl (bleaching), and povidone–iodine (white spot–like lesion). Compared with the control, there was no significant difference in mineral loss and lesion depth with any of the groups, but the numerical values of mineral loss and lesion depth in groups can be ranked as follows: gamma irradiation

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Bactericidal Activity of Skin Disinfectants on Methicillin-Resistant Staphylococcus aureus

Cited by 20 publications

References 16 publications

Comparison of Four Antiseptic Preparations for Skin in the Prevention of Contamination of Percutaneously Drawn Blood Cultures: a Randomized Trial

Comparison of Four Antiseptic Preparations for Skin in the Prevention of Contamination of Percutaneously Drawn Blood Cultures: a Randomized Trial

The Effect of a Scenario based Hand Hygiene Education Program on Hand Hygiene Knowledge, Hand Hygiene Perception, Hand Hygiene Compliance and Hand Hygiene Method in Nursing Students<sup>*</sup>

Efficacy of Sterilisation Methods and Their Effect on Enamel Demineralisation

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