Bactericidal activity of gentamicin against<i>S. aureus</i>: In vitro study questions value of prolonged high concentrations

Sôrensen, Torben Sandberg; Sörensen, Allan Ibsen

doi:10.3109/17453679308994537

Cited by 16 publications

(7 citation statements)

References 7 publications

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“…Thus, it is important to have a high concentration of gentamicin released to the media in the first hour, as we demonstrated in the Figure 6, in order to eliminate all bacterial contamination. These authors also reported that after the first hour of incubation, the kill rate was independent of the gentamicin concentration in both media (MH and WF), suggesting that the gentamicin-loaded membranes can control the bacterial growth for at least one week (Figure 7) 25 .…”

Section: Antibacterial Activitymentioning

confidence: 85%

Section: Antibacterial Activitymentioning

confidence: 99%

“…Sorensen and Sorensen (1993) investigated the antibacterial activity of gentamicin against four strain of S. aureus using Mueller-Hinton (MH) broth and surgical wound fluid (WF) as test media 25 . According to the authors, during the first hour of incubation, there was a marked concentrationdependent kill rate 25 . Thus, it is important to have a high concentration of gentamicin released to the media in the first hour, as we demonstrated in the Figure 6, in order to eliminate all bacterial contamination.…”

Section: Antibacterial Activitymentioning

confidence: 99%

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Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release

et al. 2018

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Section: Antibacterial Activitymentioning

confidence: 85%

Section: Antibacterial Activitymentioning

confidence: 99%

Section: Antibacterial Activitymentioning

confidence: 99%

See 1 more Smart Citation

Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release

et al. 2018

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“…The only possible objection to the use of gentamicin-impregnated xenografts in the treatment of chronic osteomyelitis may be the relatively short duration of antibiotic release, but for patients with osteomyelitis, the duration of antibiotic administration is controversial and the standard 6 weeks has no documented superiority over treatment for one week [1,12]. The benefit of prolonged high concentration of gentamicin is restricted for the first hour it is applied [16]. In the present study, we did not use additional systemic antibiotics, and so we have clearly demonstrated the effectiveness of our delivery system.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic-impregnated xenografts in the treatment of chronic osteomyelitic cavities

Seber

Günal

Göktürk

1998

International Orthopaedics

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“…Time-kill curves over 24 hours in wound fluid for gentamicin against S. aureus . The concentrations of gentamicin tested were 1 to 1024 ug/ml.Source: Adapted from Sørensen et al 23 …”

Section: Differences In Susceptibility or Resistance Between Systemicmentioning

confidence: 99%

Risk assessment of antibiotic resistance development by antibiotic-loaded bone cements: is it a clinical concern?

Berberich

Sanz-Ruíz

2019

EFORT Open Reviews

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Because of the risk of bacterial biofilm infections, prophylactic use of antibiotics in orthopaedic procedures involving the implantation of large prosthesis systems is considered mandatory. A strategy based on the rationale that local antibiotics released from bone cement or other carriers establish a second antibacterial frontline in and around the prosthesis is considered complementary to the administration of systemic antibiotics. Although less common as a consequence of the initially very high drug concentrations of local antibiotics in the tissues, a selection process of previous high resistance bacteria may occur, leading to antibiotic resistance. The use of antibiotic combinations in bone cement is generally accepted to improve antibiotic efficacy and minimizes the treatment failure risk due to antibiotic resistance. This is important in septic revisions and/or in patients at particularly high risk of infection. On an individual basis, the benefit of a lower infection probability with combined systemic and local antibiotic application should outweigh the risk of the selection of more resistant bacteria. Each prevented infection means that a complex and extended antibiotic therapy with risk of resistance development over time has been avoided. On an epidemiological level there is no clinical evidence that the routine use of bone cement impregnated with appropriate bactericidal antibiotics promotes the widespread development of antibiotic resistance and thereby puts the successful treatment of a prosthetic joint infection at higher risk. Cite this article: EFORT Open Rev 2019;4:576-584. DOI: 10.1302/2058-5241.4.180104

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Bactericidal activity of gentamicin againstS. aureus: In vitro study questions value of prolonged high concentrations

Cited by 16 publications

References 7 publications

Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release

Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release

Antibiotic-impregnated xenografts in the treatment of chronic osteomyelitic cavities

Risk assessment of antibiotic resistance development by antibiotic-loaded bone cements: is it a clinical concern?

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