Bactericidal activity of caprylic acid entrapped in mesoporous silica nanoparticles

Ruiz-Rico, María; Fuentes, Cristina; Pérez‐Esteve, Édgar; Jiménez-Belenguer, Ana; Quiles, Amparo; Marcos, M. Dolores; Martínez‐Máñez, Ramón; Baviera, José Manuel Barat

doi:10.1016/j.foodcont.2015.03.016

Cited by 27 publications

(22 citation statements)

References 40 publications

(65 reference statements)

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“…More recently, Yu et al. () have described the use of poly(N‐isopropylacrylamide)‐gated Fe 3 O 4 ‐MSNs core shell nanoparticles for the temperature‐triggered release of antibacterial enzyme lysozyme, and we stated the antimicrobial effect of caprylic acid incorporated in MSNs (Ruiz‐Rico et al., ). Following an alternative approach, Li and Wang () reported the use of lysozyme‐coated MSNs as antibacterial agents, and Qi, Li, Yu, and Wang () used vancomycin‐modified MSNs to kill pathogenic Gram‐positive bacteria.…”

Section: Introductionmentioning

confidence: 73%

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Improving the Antimicrobial Power of Low‐Effective Antimicrobial Molecules Through Nanotechnology

Ruiz-Rico

Pérez‐Esteve

Torre

et al. 2018

Journal of Food Science

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Consumers demand for high-quality products, free from chemical preservatives, with an extended shelf-life. In this study, a really powerful antimicrobial agent based on a nanomaterial functionalized with a non-antimicrobial organic molecule was developed as a proof of concept. Following this approach it could be possible to develop a new generation of natural and removable antimicrobials based on their anchoring to functional surfaces for food, agricultural or medical purposes.

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Section: Introductionmentioning

confidence: 73%

“…MSNs were prepared using TEOS as a silica precursor and CTABr as a structure directing agent (Ruiz‐Rico et al., ). The as made nanoparticles were calcined to yield the bare mesoporous nanoparticles (B‐N).…”

Section: Resultsmentioning

confidence: 99%

Improving the Antimicrobial Power of Low‐Effective Antimicrobial Molecules Through Nanotechnology

Ruiz-Rico

Pérez‐Esteve

Torre

et al. 2018

Journal of Food Science

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“…Formulation technologies for overcoming these drawbacks include nanoemulsions, β‐cyclodextrin encapsulation, and various polymer‐based films . Recently, novel encapsulation technologies enabling sustained release have become an important strategy for improving the applicability of natural antimicrobials, and encapsulation into nanocomposites has proved suitable for protecting and preserving the effectiveness of bioactive substances . However, the porous structures used for encapsulation are typically produced via expensive and complex synthetic routes.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of essential oil components loaded into montmorillonite against Aspergillus niger and Staphylococcus aureus

Bernardos

Božík

Álvarez

et al. 2019

Flavour & Fragrance J

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Essential oil components (EOCs) are potent natural antimicrobial agents, but their high volatility and reactivity limit their potential applications. Here, we report the preparation of a series of nanomaterials containing EOCs (i.e., allyl isothiocyanate, carvacrol, cinnamaldehyde, diallyl disulphide, eugenol and thymol). The materials were prepared by simple adsorption of the EOCs onto a montmorillonite nanoclay. The antimicrobial activities of these materials were assessed against Aspergillus niger and Staphylococcus aureus as typical models of agricultural fungal pathogens and foodborne bacterial pathogens, respectively. In addition, the activities of the encapsulated EOCs were compared with those of the corresponding free forms with or without Tween‐80 in two types of assays: microdilution assays for determining the minimum inhibitory concentration (MIC) and agar‐based assays mimicking surface treatment. Enhanced antifungal activity of the encapsulated form was observed for all EOCs. In addition, against S. aureus, the MICs of all EOCs were remarkably lower in encapsulated form than in free form. These results indicate that EOCs encapsulated in low‐cost nanoclays have favourable potential as antimicrobials compared with the pure compounds.

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“…For instance, MCM‐41 type MS NPs loaded with caprylic acid were prepared by Marcos and co‐workers, and their antibacterial activity against E. coli , S. enterica , S. aureus , and L. monocytogenes was studied . The prepared nanoparticles showed a total inhibition of bacterial growth at concentration of released caprylic acid in the 18.5–20 × 10 −3 m range.…”

Section: Ms In Antibacterial Applicationsmentioning

confidence: 99%

Mesoporous Silica‐Based Materials with Bactericidal Properties

Bernardos

Piacenza

Sancenón

et al. 2019

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130

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Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections. At first, the emergency of bacterial and biofilm resistance toward conventional antimicrobials is described and then how nanoparticles exert their toxic effects upon pathogenic cells is discussed. Next, the main aspects of MSMs (e.g., physicochemical properties, multifunctionality, and biosafety) which one should consider in the design of MSM‐based DDSs against bacterial infections are introduced. Finally, a comprehensive analysis of all the papers published dealing with the use of MSMs for delivery of antibacterial chemicals (antimicrobial agents functionalized/adsorbed on mesoporous silica (MS), MS‐loaded with antimicrobial agents, gated MS‐loaded with antimicrobial agents, MS with metal‐based nanoparticles, and MS‐loaded with metal ions) is provided.

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Bactericidal activity of caprylic acid entrapped in mesoporous silica nanoparticles

Cited by 27 publications

References 40 publications

Improving the Antimicrobial Power of Low‐Effective Antimicrobial Molecules Through Nanotechnology

Improving the Antimicrobial Power of Low‐Effective Antimicrobial Molecules Through Nanotechnology

The efficacy of essential oil components loaded into montmorillonite against Aspergillus niger and Staphylococcus aureus

Mesoporous Silica‐Based Materials with Bactericidal Properties

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