Bacterial vaginosis is conducive to the persistence of HPV infection

Yl, Guo; You, Ke; Qiao, Jie; Zhao, Yanfang; Geng, Li

doi:10.1258/ijsa.2012.011342

Cited by 97 publications

(72 citation statements)

References 26 publications

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“…There is also evidence to suggest that persistence is more likely in those with altered microbiome. In one study, women with persistent high risk (hr) HPV had a prevalence of BV of 11% compared to only 5% in those women who cleared their hrHPV 75 . Similarly, King et al 76 found that women diagnosed with BV had delayed clearance of HPV (adjusted Hazard ratio (aHR)=0.84, 95%CI: 0.72, 0.97).…”

Section: Hpv Infection and The Vaginal Microbiomementioning

confidence: 99%

Does the vaginal microbiota play a role in the development of cervical cancer?

Kyrgiou

Mitra

Moscicki

2017

Translational Research

197

174

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Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary but not sufficient for the development of cervical cancer. The factors promoting persistence as well those triggering carcinogenetic pathways are incompletely understood. Rapidly evolving evidence indicates that the vaginal microbiome (VM) may play a functional role (both protective and harmful) in the acquisition and persistence of HPV, and subsequent development of cervical cancer. The first studies examining the vaginal microbiome and the presence of an HPV infection using next generation sequencing techniques (NGS) identified higher microbial diversity in HPV-positive as opposed to HPV-negative women. Furthermore, there appears to be a temporal relationship between the VM and HPV infection in that specific community state types (CSTs) may be correlated with a higher chance of progression or regression of the infection. Studies describing the VM in women with pre-invasive disease (squamous intra-epithelial neoplasia – SIL) consistently demonstrate a dysbiosis in women with the more severe disease. Although it is plausible that the composition of the VM may influence the host innate immune response, susceptibility to infection and the development of cervical disease, the studies to date do not prove causality. Future studies should explore the causal link between the VM and the clinical outcome in longitudinal samples from existing biobanks.

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Section: Hpv Infection and The Vaginal Microbiomementioning

confidence: 99%

Does the vaginal microbiota play a role in the development of cervical cancer?

Kyrgiou

Mitra

Moscicki

2017

Translational Research

197

174

View full text Add to dashboard Cite

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“…The Hay/Ison criteria used for diagnosis of BV in the UK is largely based on the presence or absence of both Lactobacillus and Gardnerella or Mobiluncus morphotypes [27]. BV has previously been correlated with higher incidence, prevalence and persistence of HPV infection and with development of CIN [28–31]. However, other studies did not find a positive correlation between CIN and BV [32–34], which may partly be explained by the lack of objective diagnostic tests for BV, the reliance on subjective scoring systems [35] and the heterogeneity of BV itself.…”

Section: Introductionmentioning

confidence: 99%

The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?

et al. 2016

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The vaginal microbiota plays a significant role in health and disease of the female reproductive tract. Next-generation sequencing techniques based upon the analysis of bacterial 16S rRNA genes permit in-depth study of vaginal microbial community structure to a level of detail not possible with standard culture-based microbiological techniques. The human papillomavirus (HPV) causes both cervical intraepithelial neoplasia (CIN) and cervical cancer. Although the virus is highly prevalent, only a small number of women have a persistent HPV infection and subsequently develop clinically significant disease. There is emerging evidence which leads us to conclude that increased diversity of vaginal microbiota combined with reduced relative abundance of Lactobacillus spp. is involved in HPV acquisition and persistence and the development of cervical precancer and cancer. In this review, we summarise the current literature and discuss potential mechanisms for the involvement of vaginal microbiota in the evolution of CIN and cervical cancer. The concept of manipulation of vaginal bacterial communities using pre- and probiotics is also discussed as an exciting prospect for the field of cervical pathology.

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“…Vaginosis was observed in 9.1% of patients who were HC2-negative for HPV, while vaginosis was observed in 22.4% of HC2-positive patients (p=0.012). Guo et al (25) reported that, compared to women without BV, women with BV had a lower clearance of HPV infection. All these findings can be explained by the hypothesis that susceptibility to HPV and the immune system's ability to clear HPV can be affected by vaginal bacterial infections, which disrupt the balance of the vaginal microbiota (7,26) .…”

Section: Discussionmentioning

confidence: 99%

Influence of human papillomavirus infection on the vaginal microbiome of women with immunocompetency

Rebouças¹,

Eleutério²,

Eleutério³

et al. 2014

J bras doenças sex transm

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Introduction:The influence of vaginal infections on the natural history of human papillomavirus (HPV) is still unclear. Objective: To determine if patients with low-grade squamous intraepithelial lesions (LSILs) and HPV have more vulvovaginitis than patients with normal liquid-based cervical cytology who were negative for HPV. Methods: This is a cross-sectional study including 322 patients who underwent cervical exams. One hundred and sixty-seven of these patients had LSILs on cervical cytology and were simultaneously hybrid capture 2 (HC2)-positive for HPV, and the remaining 155 patients were negative for malignancies and intraepithelial lesions by cytology and HC2-negative for HPV. The prevalence of vaginal infections in both groups was compared using the χ 2 test without Yates' correction. Results: Among the patients with HPV and LSILs, the most common vaginal infection was vaginosis (8.98%) compared to candidiasis (12.9%) in the patients without LSILs and HPV. No significant differences were found in the prevalence of vaginosis between the two groups (p=0.53). Candidiasis was statistically more prevalent in patients without LSILs and HPV (p<0.001). Conclusion: An association was found between the presence of Candida and the absence of HPV. Although vaginosis was more frequent among patients with LSILs and HPV, it was not statistically significant.

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Bacterial vaginosis is conducive to the persistence of HPV infection

Cited by 97 publications

References 26 publications

Does the vaginal microbiota play a role in the development of cervical cancer?

Does the vaginal microbiota play a role in the development of cervical cancer?

The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?

Influence of human papillomavirus infection on the vaginal microbiome of women with immunocompetency

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