Bacterial Vaginosis: Identifying Research Gaps Proceedings of a Workshop Sponsored by DHHS/NIH/NIAID

Marrazzo, Jeanne M.; Martín, David H.; Watts, D. Heather; Schulte, Joann; Sobel, Jack D.; Hillier, Sharon L.; Deal, Carolyn D.; Fredricks, David N.

doi:10.1097/olq.0b013e3181fbbc95

Cited by 97 publications

(80 citation statements)

References 77 publications

(87 reference statements)

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“…This microbially mediated vaginal acidity provides an important barrier that restricts the colonization of potential pathogens (Boskey et al, 1999). Perturbations to the composition of the human vaginal microbiome are often associated with diseased states, including bacterial vaginosis (BV) (Fredricks et al, 2005;Oakley et al, 2008;Marrazzo et al, 2010;Srinivasan et al, 2010), susceptibility to sexually transmitted infectious diseases (Sewankambo et al, 1997;Wiesenfeld et al, 2003), tubal infertility (Wiesenfeld et al, 2012;van Oostrum et al, 2013) and adverse pregnancy outcomes (White et al, 2011;Ganu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Given the known importance of the vaginal microbiome for female sexual and reproductive health and their role as microbial colonists for newborns (Tannock et al, 1990;Mandar and Mikelsaar, 1996;Leitich and Kiss, 2007;CDC, 2009;Biasucci et al, 2010;DominguezBello et al, 2010;Marrazzo et al, 2010), host-vaginal microbiome interactions could comprise a strong selection force having a pivotal role in the evolution of humans and other primates. Primates are ideal hosts for studying variation in vaginal microbiota, because primate species differ markedly in their diet, anatomy, mating systems, gestational durations, birthing difficulties, and commensurate risks of maternal injury and subsequent infection (Rosenberg and Trevathan, 2002;Campbell et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance

et al. 2014

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Bacterial communities colonizing the reproductive tracts of primates (including humans) impact the health, survival and fitness of the host, and thereby the evolution of the host species. Despite their importance, we currently have a poor understanding of primate microbiomes. The composition and structure of microbial communities vary considerably depending on the host and environmental factors. We conducted comparative analyses of the primate vaginal microbiome using pyrosequencing of the 16S rRNA genes of a phylogenetically broad range of primates to test for factors affecting the diversity of primate vaginal ecosystems. The nine primate species included: humans (Homo sapiens), yellow baboons (Papio cynocephalus), olive baboons (Papio anubis), lemurs (Propithecus diadema), howler monkeys (Alouatta pigra), red colobus (Piliocolobus rufomitratus), vervets (Chlorocebus aethiops), mangabeys (Cercocebus atys) and chimpanzees (Pan troglodytes). Our results indicated that all primates exhibited host-specific vaginal microbiota and that humans were distinct from other primates in both microbiome composition and diversity. In contrast to the gut microbiome, the vaginal microbiome showed limited congruence with host phylogeny, and neither captivity nor diet elicited substantial effects on the vaginal microbiomes of primates. Permutational multivariate analysis of variance and Wilcoxon tests revealed correlations among vaginal microbiota and host species-specific socioecological factors, particularly related to sexuality, including: female promiscuity, baculum length, gestation time, mating group size and neonatal birth weight. The proportion of unclassified taxa observed in nonhuman primate samples increased with phylogenetic distance from humans, indicative of the existence of previously unrecognized microbial taxa. These findings contribute to our understanding of host-microbe variation and coevolution, microbial biogeography, and disease risk, and have important implications for the use of animal models in studies of human sexual and reproductive diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance

et al. 2014

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“…Это мож-но объяснить тем, что в современных условиях изменились свойства микроорганизмов -их вирулентность и патогенность, перестроилась этиологическая структура инфекционных забо-леваний, более того, изменились особенности реагирования на инфекционные агенты иммун-ной системы. В недавних работах было отме-чено, что у 30 % женщин рецидив БВ встреча-ется через три месяца, а у 50 % спустя полгода после терапии [47]. Поскольку состав микро-флоры при БВ напоминает состав микрофлоры перианальной области, то существует предпо-ложение о связи этих микробиоценозов, однако непосредственных подтверждений этому пока не найдено [48,49].…”

Section: роль биопленок в формировании патологических процессов во влunclassified

The role of bacterial biofilms in the development of chronic pathological processes in the vagina and endometrium

2016

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Microbial biofilms are a problem in many areas of medicine. When the vaginal ecological system is disturbed, well-structured polymicrobial biofilm, covering the vaginal epithelium and consisting of anaerobic bacteria, is formed, which may lead to the development of recurrent bacterial vaginosis. During an ascending infection and the development of chronic endometritis, bacterial biofilms are detected in the endometrium. Biofilms formed by bacteria residing in the urogenital tract of woman, may result in dysfunctions of the reproductive system, in-vitro fertilization failures, complications of pregnancy, adverse pregnancy outcomes. In the paper, literature data regarding causes of of biofilm formation, methods of detection and treatment of biofilm infections are reviewed.

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“…Despite this work, scientists recognized relatively early that there likely were members of these communities that could not be cultured ex vivo; thus, the true nature of the human microbiome remained obscure. The discovery that it was possible to amplify bacterial 16S RNA genes directly from natural samples (for review see Marrazzo et al, 2010) and use the sequences thus obtained to identify most bacterial species present in such samples resulted in the first accurate descriptions of site-specific human microbiota. Such molecular analyses highlighted the inadequacies of the methods of classic bacteriology, important as they were, to accurately describe the true complexity of the human microbiome.…”

Section: Introductionmentioning

confidence: 99%

Endogenous Microbiota of the Genitourinary Tract

Martín

Ferris

2015

Mucosal Immunology

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Bacterial Vaginosis: Identifying Research Gaps Proceedings of a Workshop Sponsored by DHHS/NIH/NIAID

Cited by 97 publications

References 77 publications

Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance

Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance

The role of bacterial biofilms in the development of chronic pathological processes in the vagina and endometrium

Endogenous Microbiota of the Genitourinary Tract

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