Bacterial vaginosis and inflammatory response showed association with severity of cervical neoplasia in HPV‐positive women

Donders, Gilbert; Vieira‐Baptista, Pedro

doi:10.1002/dc.23453

Cited by 11 publications

(6 citation statements)

References 7 publications

(12 reference statements)

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“…In South Africa and Uganda, however, it was clearly shown that AVF and AV are more frequent than in other parts of the world [ 25 , 26 ] and presumably account for many of the potential side effects and STI transmission risk factors allegedly accounted to BV in several former studies [ 24 , 27 ]. We currently did not find a clear association between cytology/positive HR-HPV and disrupted flora types such as AV or BV as Jahic, Vieira-Baptista, and Donders found [ 28 , 29 ], but this can most likely be accounted to small numbers and pleas for more extensive research.…”

Section: Discussionmentioning

confidence: 90%

Genital Tract Infections in an Isolated Community: 100 Women of the Príncipe Island

Vieira‐Baptista

Grincevičienė

Bellen³

et al. 2017

Infectious Diseases in Obstetrics and Gynecology

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Objective To characterize the vaginal microbiome and the rate of sexually transmitted infections (STIs) in the women of Príncipe (São Tomé and Príncipe). Methods Cross-sectional study of 100 consecutive women, invited for a free appointment and cervical cancer screening. A vaginal slide (wet mount microscopy) and a cervical sample (ThinPrep®) (Pap test, high risk human papillomavirus [HR-HPV], N. gonorrhea [NG], T. vaginalis [TV], and C. trachomatis [CT]) were obtained. Results TV, NG, CT, and HIV were found in 8.0%, 2.0%, 3.0%, and 2.0%, respectively, and were more prevalent in younger women. HR-HPV was positive in 36.7%; 2 were positive for HPV18, but none for HPV16. Coinfection of HPV with other STIs was 8.3%. Prevalence of abnormal vaginal flora (AVF) was 82.5%, mostly bacterial vaginosis (BV) 54.6%, and moderate/severe aerobic vaginitis (msAV) 25.8%. HR-HPV was not related to BV (p = 0.67). The association of abnormal Pap test with msAV was not significant (p = 0.08). Conclusion The prevalence of NG, CT, TV, and HR-HPV was according to expected, while that of HR-AVF was higher. The surprisingly low prevalence of HPV16 and HPV18 must be considered in the design of programs for prevention and vaccination; this setting can be useful as a model for postvaccination scenarios.

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Section: Discussionmentioning

confidence: 90%

Genital Tract Infections in an Isolated Community: 100 Women of the Príncipe Island

Vieira‐Baptista

Grincevičienė

Bellen³

et al. 2017

Infectious Diseases in Obstetrics and Gynecology

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“…An increased pH (a marker of lactobacilli depletion and, thus, dysbiosis) is found not only in BV, but also in con- ditions in which aerobic, rather than anaerobic, bacteria predominate. Besides the overgrowth of aerobic bacteria, these women usually also have atrophy and inflammation (which are not part of BV) [76]. This entity was named aerobic vaginitis (AV) by Donders et al in 2002 [77].…”

Section: Dysbiosismentioning

confidence: 99%

Candidiasis, Bacterial Vaginosis, Trichomoniasis and Other Vaginal Conditions Affecting the Vulva

Vieira‐Baptista

Bornstein

2019

Vulvar Disease

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“…Such an association has also been proved among Uyghur women in Xinjiang [15][16][17][18][19]. Bacterial vaginitis and Trichamonas vaginalis infection contribute to the development of cervical cancer [20,21]. Oral contraceptives accelerate the progress of cervical lesion development; genital warts, intercourse bleeding, multiple pregnancies and births, multiple sexual partners, and first sexual behavior at an early age are closely associated with cervical cancer and precancerous lesion [22,23].…”

Section: Introductionmentioning

confidence: 92%

Prevalence and risk factors of cervical cancer in the Nanjiang area of the Xinjiang Uyghur Autonomous Region of China: a matched case-control study

Han¹,

Husaiyin²,

Wang³

et al. 2021

European Journal of Gynaecological Oncology

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Nanjiang is the area where cervical cancer has a high incidence in the Xinjiang Uyghur Autonomous Region, China. However, large-scale studies on the risk factors in this area have rarely been reported. This study investigated the prevalence and risk factors of cervical cancer in Nanjiang. Methods: A total of 10,038 nonpregnant women with a history of sexual intercourse were screened from five areas of Nanjiang. Their age ranged from 18 years to 64 years. The participants received physical examination, questionnaire surveys, laboratory examinations and cervical cancer screening. A case-control study was designed for 60 women diagnosed with cervical cancer, and uni-and multi-variable logistic regression analyses were performed. Results: The prevalence of cervical cancer was 59.77/100,000. The factors associated with cervical cancer included unwilling for physical exercise (Odds Ratio (OR) = 1.96, Confidence interval (95% CI) = 1.02~3.78, p = 0.043), the number of sexual partners ≥5 (OR = 2.36, 95% CI = 1.15~4.81, p = 0.019), high-risk human papilloma virus (HPV) infection (OR = 2.73, 95% CI = 1.35~5.53, p = 0.005), herpes simplex virus (HSV) infection (OR = 2.57, 95% CI = 1.33~4.96, p = 0.005), and a family history of cervical cancer within three generations (OR = 4.41, 95% CI = 2.21~8.61, p < 0.001). High-risk HPV infection and HSV-2 infection interacted with each other among these factors (OR = 3.61, 95% CI = 1.80~7.22, p < 0.001). Conclusions: HPV infection, sexual behavior, sexually transmitted diseases and heredity are associated with cervical cancer among Uyghur women in Nanjiang. In the prevention and treatment of cervical cancer, biological and behavioral factors should be comprehensively considered.

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Bacterial vaginosis and inflammatory response showed association with severity of cervical neoplasia in HPV‐positive women

Cited by 11 publications

References 7 publications

Genital Tract Infections in an Isolated Community: 100 Women of the Príncipe Island

Genital Tract Infections in an Isolated Community: 100 Women of the Príncipe Island

Candidiasis, Bacterial Vaginosis, Trichomoniasis and Other Vaginal Conditions Affecting the Vulva

Prevalence and risk factors of cervical cancer in the Nanjiang area of the Xinjiang Uyghur Autonomous Region of China: a matched case-control study

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