Bacterial target sites for biocide action

Maillard, Jean‐Yves

doi:10.1046/j.1365-2672.92.5s1.3.x

Cited by 380 publications

(303 citation statements)

References 91 publications

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“…The high performance of some of these antibiotics (Gentamicin, Ciprofloxacin and Chloramphenicol) could also be due to their molecular sizes a factor which enhances their solubility in diluents thus promoting their penetration power through cell wall into the cytoplasm of the target microorganism. This finding is in line with Mailard (2002) and Poole (2002) who respectively opined that the high efficacy of antibiotics may be traced to their molecular sizes. The present study revealed a high resistance to tetracycline (85.71%), a commonly used antibiotic by the S. aureus isolates.…”

Section: Discussionsupporting

confidence: 86%

Occurrence and antibiogram of <i>Staphylococcus aureus</i> in dairy products consumed in parts of Kaduna State, Nigeria

Okpo¹,

Abdullahi²,

Whong³

et al. 2017

Bayero J. Pure App. Sci.

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A total of 160 dairy products comprising of 80 each of fresh milk and 'Nono' (Fermented and defatted) were collected. The samples were cultured and identified by routine bacteriological methods. Prevalence of S.aureus (8.75%) in the products was; for fresh milk 3.75% and 'Nono' 5%. The susceptibility profile of the isolates to nine antimicrobial agents revealed a high susceptibility to Gentamicin (100%), Ciprofloxaxin (92.86%) and Chloramphenicol (92.86%). The isolates had high resistance to Tetracycline (85.71%), Cefoxitin (64.29%), Amoxicillin/Clavulanic acid (64.29%) and Erythromycin (64.29%). A total of 9(64.29%) isolates were resistant to multiple antibiotics. Multiple antibiotics resistance index (MARI) ranged from 7.14% (0.7) to 21.43% (0.3). The presence of S.aureus and resistance to commonly used antibiotics by the isolates posses a health risk for consumers of these milk products.

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Section: Discussionsupporting

confidence: 86%

Occurrence and antibiogram of <i>Staphylococcus aureus</i> in dairy products consumed in parts of Kaduna State, Nigeria

Okpo¹,

Abdullahi²,

Whong³

et al. 2017

Bayero J. Pure App. Sci.

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“…Gram negative bacteria are generally less sensitive to biocides than Gram positive bacteria because of their outer membrane or envelope. The outer cell layer of Gram negative bacteria consists of an outer membrane, a thin layer of peptidoglycan and a periplasmic space and an inner membrane [58]. One of the effects of the outer envelope is to form an impermeable barrier that protects the microorganism from toxic molecules such as biocides and antibiotics.…”

Section: Antimicrobial Activity Of Coumarin Ligands and Their Ag(i) Cmentioning

confidence: 99%

Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms

et al. 2014

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a b s t r a c tA novel series of coumarin-4-carboxylate ligands (2a-2l), their Ag(I) complexes (3a-3l) together with a number of their phenanthroline adducts (4d, 4f and 4g) have been synthesised and characterised. The ligands were prepared by either acid or base hydrolysis of their corresponding esters or by demethylation of a methylated acid derivative. The esters (1a-1i) were synthesised by an aromatic electrophilic substitution reaction between the conjugate base of substituted phenols and a vinyltriphenylphosphonium salt. The novel series of Ag(I) carboxylate complexes were prepared by reaction of silver nitrate with the coumarin ligands in aqueous/alcohol solution. The Ag(I) phenanthroline adducts were prepared by reaction of the Ag(I) complex with 1,10-phenanthroline in aqueous/alcohol solution. A selection of complexes were screened for their in vitro antibacterial activity against Pseudomonas aeruginosa grown planktonically or as a biofilm as well as a number of other clinically important strains, Escherichia coli, MRSA and Staphylococcus aureus. The activity against the P. aeruginosa biofilm was found to be significantly greater than against the planktonic bacteria.

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“…accompanied by bacteriostatic; and (4) complete loss of membrane function follows by the precipitation of intracellular constituents and bactericidal effect [7][8][9][10][11][14][15][16][17]. One and ditto material at different concentration are known to be either a poison or a medicine.…”

Section: Polymericmentioning

confidence: 99%

The Polyhexamethyleneguanidine Stimulation of Seeds Growing and Cell Proliferation

Lysytsya¹,

Sergij²,

Oksana³

2013

JMSE-B

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Oligomer guanidines are highly efficient biocides against a broad spectrum of microorganisms. However, their stimulatory effects have not been studied yet. Our data allow us to expect the presence of growing stimulatory action for polyhexamethyleneguanidine (PHMG) under determined conditions. We investigated the action of the member of the polyguanidine family of biocides, PHMG on seeds growing. The comparative analysis of PHMG action was carried out on seeds of wheat, pea, rye, beet and maize. It was shown that of all PHMG salts tested only PHMG chloride and PHMG succinate could stimulate the growing of seeds. PHMG was also capable to increase their germination and vigor. The action on seeds of PHMG mixtures with inorganic salts (microelements) has also been examined. Amongst the drugs tested with a wide variety of ingredients the best stimulatory properties were proven for the composition of PHMG and succinic acid with boron, zinc, cobalt and magnesium. Most efficient growth stimulation was achieved after 15-minutes pre-sowing soaking of seeds of peas and beets. The stimulatory concentrations of PHMG were falling within the range of 0.001 to 0.5 %. Thus, the salts of PHMG can either depress or stimulate living organisms (including seeds) depending on PHMG concentration and anionic composition. The stimulation can be achieved by the non-specific adaptation of the cells (stress). In this case the stimulation is determined by the changes in the plasma membrane of the cell after adsorption of PHMG. The polycation of PHMG binds strongly with phosphoglycerides. Some lipids withdraw from participation in cellular processes. The acceleration the of new lipids synthesis and membrane-bound enzymes is likely to occure in the cell. The acceleration of new lipids synthesis and membrane-bound enzymes is likely to occur in the cell.

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Bacterial target sites for biocide action

Cited by 380 publications

References 91 publications

Occurrence and antibiogram of <i>Staphylococcus aureus</i> in dairy products consumed in parts of Kaduna State, Nigeria

Occurrence and antibiogram of <i>Staphylococcus aureus</i> in dairy products consumed in parts of Kaduna State, Nigeria

Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms

The Polyhexamethyleneguanidine Stimulation of Seeds Growing and Cell Proliferation

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