Bacterial spectrum and antibiotic resistance of urinary tract infections in patients treated for upper urinary tract calculi: a multicenter analysis

Lorenzis, E. De; Alba, A. Budía; Cepeda, M.; Galán, J.A.; Geavlete, P.; Giannakopoulos, Stilianos; Saltirov, I.; Sarıca, Kemal; Skolarikos, Andreas; Stavridis, Sotir; Yürük, Emrah; Geavlete, B.; García-Carbajosa,; Hristoforov, Stefan; Karagöz, Mehmet Ali; Nassos, Nikolaos; Jurado, G. Ordaz; Paslanmaz, Filip; Poza, Marina; Saidi, Skender; Tzelves, Lazaros; Trinchieri, Alberto

doi:10.1007/s10096-020-03947-z

Cited by 18 publications

(15 citation statements)

References 21 publications

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“…The spectrum of isolated uropathogens showed obvious differences between infection stones and noninfection stones. In urine, the antimicrobial spectrum of E. coli, the most commonly encountered bacteria in patients with infection and non-infection stones, was consistent with reports in the literature [24,25].…”

Section: Discussionsupporting

confidence: 88%

Clinical Characteristics of Bacterial Spectrum and Antimicrobial Resistance in Urine and Stone Cultures From Patients With Kidney Stone Disease

Lei

Jiang

et al. 2021

Preprint

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Background It is important to understand the clinical characteristics of bacterial spectrum and antibiotic resistance of urine and stone pathogens for the prevention and treatment of urolithiasis and perioperative infection. Methods Consecutive patients with kidney stones treated by percutaneous nephrolithotomy (PCNL) from September 2016 to September 2018 were included. The bacterial species and antibiotic sensitivity test of the germs cultured from clean middle-stream urine and from stones intraoperatively were evaluated. Results In 1055 patients, the rate of positive bacterial test was higher in stones than in urine (337, 31.0% vs. 221, 20.9%, p=0.016). 167(15.8%) patients had both positive urine culture (UC) and stone culture (SC), of which 137 (82.0%) had identical bacteria in both cultures. In infection stone patients, the positive rate of bacteria was 34.7% (91/262) in urine and 52.3% (137/262) in stone, and in non-infection stone patients, was 16.4% (130/793) and 25.2% (200/793). The positive rate of SC in patients with different types of stones were higher than that of UC. E. coli was the most common organism not only in both UC (54.3% ,120/221) and SC (43.9%,148/337) but also in urine and stones from patients with infection stones (44.0%,32.8%) or non-infection stones (61.5%,51.8%). Furthermore, the pathogens isolated from urine and stones showed high resistance to fluoroquinolones, ceftriaxone, cefazolin, cefuroxime, β-lactamases and sulfonamides (all resistance>20%). Conclusions The bacterial spectra demonstrated in stones and urine samples were significantly different. Positive SC was more commonly encountered than positive UC. Compared with non-infection stones, infection stones were accompanied by higher rates of positive tests in both cultures. The antibiotic resistance was comparable between bacteria in the two cultures. A combination of antibiotic sensitivity results in urine and stones might be a useful guide for selection of effective and appropriate treatment aiming at reduced problems with bacterial antibiotic resistance.

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Section: Discussionsupporting

confidence: 88%

Clinical Characteristics of Bacterial Spectrum and Antimicrobial Resistance in Urine and Stone Cultures From Patients With Kidney Stone Disease

Lei

Jiang

et al. 2021

Preprint

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“…As emphasized by Borghi et al [72], the relationship between nephrolithiasis and urinary tract infections is complex and difficult to analyse both from a pathophysiological and clinical point of view. This has prompted several investigations to understand the relationship between infection and urinary stones [73,74], most of them focussing on struvite [75][76][77][78][79][80][81]. Here we attempt to broaden the scope of studies of this pathogenesis by describing in detail the physicochemical characteristics of stones containing Wk without struvite.…”

Section: Results and Commentsmentioning

confidence: 99%

Whitlockite structures in kidney stones indicate infectious origin: a scanning electron microscopy and Synchrotron Radiation investigation

Bazin¹,

Papoular²,

Elkaı̈m³

et al. 2022

Comptes Rendus. Chimie

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“…Local antibiotic susceptibility and microbiological flora are extremely helpful planning adequate pre‐ and post‐operative empirical antibiotic therapy when microbiological assessment results are temporarily unavailable. However, urine bacteriology in patients with urinary stones appears to have a complex pattern 8,9 . It is unclear whether men and women with UTI stones have the same antimicrobial efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…However, urine bacteriology in patients with urinary stones appears to have a complex pattern. 8 , 9 It is unclear whether men and women with UTI stones have the same antimicrobial efficacy.…”

Section: Introductionmentioning

confidence: 99%

Gender differences in the microbial spectrum and antibiotic sensitivity of uropathogens isolated from patients with urinary stones

Chen

Yang

et al. 2021

Clinical Laboratory Analysis

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Purpose The characteristics and resistance patterns of urine bacteriology urolithiasis patients between male and female have not been extensively studied. This study aims to investigate the gender differences in microbial spectrum and antibiotic susceptibility of uropathogens isolated from urolithiasis patients and provide insights for appropriate antimicrobial therapies. Materials and Methods We retrospectively collected clinical microbiology data from urine culture in urolithiasis patients between March 2014 and December 2018 in Xiangya Hospital. Then the patients were divided into male and female groups. The microbial spectrum and frequency of susceptibility to antibiotics were compared. Results A total of 359 uropathogen isolates were collected from 335 patients, including 144 males (43.0%) and 191 females (57.0%). E. coli dominated in both groups, indicating higher frequency in females (53.2%) than in males (26.6%, p < 0.001), followed by E. faecalis, with higher frequency in males (15.6%) than in females (2.9%, p < 0.001). Major Gram‐negative (E. coli and K. pneumoniae) bacteria showed high sensitivity to cefoperazone/sulbactam, cefotetan, piperacillin/ tazobactam, and amikacin. In contrast, the resistance level was high to penicillin, tetracycline, and vancomycin in both groups. Gram‐positive (E. faecalis and E. faecium) isolates demonstrated high sensitivity to gentamicin and vancomycin in both groups. Furthermore, uropathogens isolated from female urolithiasis patients were more susceptible to antimicrobials than males. Conclusions Uropathogen microbial spectrum in female urolithiasis patients is different from males. High susceptibility antibiotics should be used empirically according to gender to avoid multidrug‐resistant bacteria increase.

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Bacterial spectrum and antibiotic resistance of urinary tract infections in patients treated for upper urinary tract calculi: a multicenter analysis

Cited by 18 publications

References 21 publications

Clinical Characteristics of Bacterial Spectrum and Antimicrobial Resistance in Urine and Stone Cultures From Patients With Kidney Stone Disease

Clinical Characteristics of Bacterial Spectrum and Antimicrobial Resistance in Urine and Stone Cultures From Patients With Kidney Stone Disease

Whitlockite structures in kidney stones indicate infectious origin: a scanning electron microscopy and Synchrotron Radiation investigation

Gender differences in the microbial spectrum and antibiotic sensitivity of uropathogens isolated from patients with urinary stones

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