Bacterial species isolated from cats with lower urinary tract infection and their susceptibilities to cefovecin

Abstract

BackgroundThe aim of this study was to determine the bacterial species recovered from 61 cats with lower urinary tract infection (LUTI), and their susceptibility to cefovecin in vitro.ResultsThe clinical signs and final clinical diagnosis for cats with confirmed LUTI were also reported. After physical examination of the cats, urine samples including ≥5-6 leucocytes in microscopic evaluation were cultured using bacteriological techniques. The isolates were identified by conventional microbiological methods and tested for in vitro susceptibility using the Kirby-Bauer disc diffusion method recommended by the Clinical Laboratory Standards Institute. Bacterial growth was observed in 16 of 61 urine samples. Antimicrobial susceptibility tests showed that 13 of 16 (81%) isolates were susceptible to cefovecin. The most frequently isolated bacterium from cats with signs of lower urinary tract infection, was Escherichia coli.ConclusionCefovecin was found to be effective in cats with LUTI. Because cefovecin is a new antimicrobial agent in veterinary medicine, there are only few studies about urine culture of cats with LUTI. It is the first study on in vitro activity of cefovecin against bacterial isolates from cats with lower urinary infections in Istanbul, Turkey.

Evaluation of lower urinary tract disease in the Yogyakarta cat population, Indonesia

“…However, in this study, male cats showed higher UTI cases than females. UTIs can also occur in healthy male cats that are catheterized, with the risk of infection increases with the duration of catheterization [ 13 , 17 ].…”

“…The second highest prevalence was seen in domestic breeds, with 58% having feline UTI. Most cats in our sample were indoor and outdoor cats that had higher risks of infection before drinking water from flower bowls and drains with bacteria infestations [ 13 ].…”

“…Microbiological tests were done on suspect samples obtained by catheterization and grown on mannitol salt agar, MacConkey agar, and blood agar (containing 5% sheep blood). The cultures were incubated at 37 o C for 24-48 h [12][13][14].…”

“…The studied patients were categorized into FIC, urolithiasis, UP, UTI, and neoplasia according to their respective diagnoses. UTI is diagnosed by significant bacterial growth from urine samples [13][14][15]. UP are diagnosed with the detection of plugs that cause urethral obstruction.…”

Cefovecin pharmacokinetics after single‐dose intramuscular administration in cheetahs (Acinonyx jubatus)

“…Cefovecin is a third‐generation cephalosporin currently approved for the treatment of skin infections in domestic dogs and cats in the United States (Stegemann, Passmore, et al, 2006; Stegemann, Sherington, and Blanchflower, et al, 2006; Stegemann, Sherington, Coati, et al, 2006; Stegemann et al, 2007), and additionally for feline urinary tract infections in other countries (Burke et al, 2017; Dokuzeylül et al, 2015; Passmore et al, 2008). Interpretive categories and breakpoints for cefovecin have been established by the Clinical Laboratory Standards Institute (CLSI) for testing pathogens from dogs and cats (CLSI, 2020).…”