Bacterial Species in Subgingival Plaque and Oral Bone Loss in Postmenopausal Women

Brennan, Renee M.; Genco, Robert J.; Wilding, Gregory E.; Hovey, Kathleen M.; Trevisan, Maurizio; Wactawski‐Wende, Jean

doi:10.1902/jop.2007.060436

Cited by 62 publications

(67 citation statements)

References 28 publications

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“…In one large study, C. rectus was found in the saliva of 31.3% of tested healthy adults from southern Finland (8). In another large study from Buffalo, NY, C. rectus was found in subgingival plaque samples from 17.6% of postmenopausal women (2). C. rectus has been found in advanced numbers from samples from patients with periodontitis compared to numbers in samples from individuals without disease in several studies (9-12, 17, 18).…”

Section: Case Reportmentioning

confidence: 99%

Oral Abscess Caused by Campylobacter rectus : Case Report and Literature Review

Mahlen

Clarridge

2009

J Clin Microbiol

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Section: Case Reportmentioning

confidence: 99%

Oral Abscess Caused by Campylobacter rectus : Case Report and Literature Review

Mahlen

Clarridge

2009

J Clin Microbiol

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“…In addition to the local tooth and gum effects, periodontal disease has been shown to influence various systemic disorders and diseases (39,71,82,87). In particular, significant associations between periodontal disease and cardiovascular disease (55), diabetes mellitus (44), preterm low birth weight (45), and osteoporosis (10) have been discovered. Patients diagnosed with periodontal disease may be at higher risk for these diseases also due to a compromised immune system, since infectious and opportunistic microbes responsible for periodontal infection may bring a burden onto the rest of the body (39).…”

mentioning

confidence: 99%

Metabolic Network Model of a Human Oral Pathogen

Mazumdar¹,

Snitkin²,

Amar³

et al. 2009

J Bacteriol

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The microbial community present in the human mouth is engaged in a complex network of diverse metabolic activities. In addition to serving as energy and building-block sources, metabolites are key players in interspecies and host-pathogen interactions. Metabolites are also implicated in triggering the local inflammatory response, which can affect systemic conditions such as atherosclerosis, obesity, and diabetes. While the genome of several oral pathogens has been sequenced, quantitative understanding of the metabolic functions of any oral pathogen at the system level has not been explored yet. Here we pursue the computational construction and analysis of the genome-scale metabolic network of Porphyromonas gingivalis, a gram-negative anaerobe that is endemic in the human population and largely responsible for adult periodontitis. Integrating information from the genome, online databases, and literature screening, we built a stoichiometric model that encompasses 679 metabolic reactions. By using flux balance approaches and automated network visualization, we analyze the growth capacity under amino-acid-rich medium and provide evidence that amino acid preference and cytotoxic by-product secretion rates are suitably reproduced by the model. To provide further insight into the basic metabolic functions of P. gingivalis and suggest potential drug targets, we study systematically how the network responds to any reaction knockout. We focus specifically on the lipopolysaccharide biosynthesis pathway and identify eight putative targets, one of which has been recently verified experimentally. The current model, which is amenable to further experimental testing and refinements, could prove useful in evaluating the oral microbiome dynamics and in the development of novel biomedical applications.

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“…Periodontitis is a chronic inflammatory process that occurs in response to a predominantly Gram-negative bacterial infection originating in dental plaque. Specific bacterial species, such as Porphyromons gingivalis, Tannerella forsythensis -have been shown to be important in etiology of periodontitis (Brennan et al, 2007). Periodontitis leads to progressive and irreversible loss of bone and periodontal ligament attachment, as inflammation extends from gingiva into adjacent bone and ligament.…”

Section: Introductionmentioning

confidence: 99%