Bacterial Resistance to Ciprofloxacin in Greece: Results from the National Electronic Surveillance System

Vatopoulos, A.; Network, Greek; Legakis, Nicholas J.

doi:10.3201/eid0503.990325

Cited by 30 publications

(22 citation statements)

References 21 publications

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“…As Table 3 shows only in the case of combination SJWA-Ethanol (5% vol/vol each) a little increase (3 -4 mm) of the halo diameter was shown. These results are in contrast with those obtained by Brehm-Steche & Johnson [17]. These authors showed an enhanced antimicrobial activity effect of increasing concentrations of pure nerolidol (0, 1 and 2 mM) on susceptibility of S. aureus to ciprofloxacin, clindamycin and tetracycline.…”

Section: Resultscontrasting

confidence: 56%

“…According to Trombetta et al [16], this action results in membrane expansion, increase of membrane fluidity and permeability, disturbance of membrane embedded proteins, inhibition of respiration, and alteration of ion transport processes. This action can contribute to the decrease of microbial resistance and avoid the spread of resistant strains [17]. Results obtained, in this study, by agar-well diffusion assay demonstrated that the SJAW did not have antimicrobial activity against tested microorganisms also when tested as undiluted (data not shown).…”

Section: Resultsmentioning

confidence: 72%

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Biological Activity of <i>Spartium junceum</i> L. (Fabaceae) Aromatic Water

Cerchiara¹,

Blaiotta²,

Straface³

et al. 2013

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In this study, antimicrobial, antioxidant and cytotoxic activities of Spartium junceum L. aromatic water (SJAW), obtained by vacuum process distillation, were investigated. Antimicrobial activity of SJAW was evaluated against fungal organisms, Gram-positive and Gram-negative bacteria using agar-well diffusion method. Moreover, the ability of SJAW to sensitize Staphyloccus aureus to antibiotics was also evaluated. The antioxidant activity was examined by 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay and the cytotoxic activity of SJAW main components was tested on melanoma RPMI 7932 and normal keratinocytes NCTC 2544 cell lines using the trypan blue method. The preparation did not show antibacterial activity against tested microorganisms and was unable, at tested concentrations/conditions, to sensitize Staphylococcus aureus to antibiotics clindamycin (2 μg) and tetracycline (30 μg). On the contrary SJAW possesses an appreciable antioxidant and cytotoxic activity suggesting its potential use for pharmaceutical applications.

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Section: Resultscontrasting

confidence: 56%

Section: Resultsmentioning

confidence: 72%

Biological Activity of <i>Spartium junceum</i> L. (Fabaceae) Aromatic Water

Cerchiara¹,

Blaiotta²,

Straface³

et al. 2013

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“…In that study, ciprofloxacin susceptibility ranged from 91.9 to 99.5%. Therefore, even though FQ resistance can vary between institutions, and certainly among different countries, the findings of this study indicate that in the United States the overall activity of these agents against Enterobacteriaceae has remained consistently high during the 1990s (2,9,11,19,26,27). The exception to this finding is the abated activity that levofloxacin and ciprofloxacin demonstrated against Providencia spp.…”

Section: Discussioncontrasting

confidence: 52%

“…The ability of clinically relevant gram-negative bacilli to develop resistance to FQs and the potential for this resistance to increase in prevalence underscore the need to monitor resistance trends (2,5,8,9,10,19,27,29,30). However, in recent years representative surveillance studies examining FQ resistance among gram-negative bacteria in the United States have been infrequent (7,13,18).…”

Section: Discussionmentioning

confidence: 99%

“…Regardless, multidrug resistance has permeated every one of the most common species of Enterobacteriaceae. Based on reports from individual institutions and from different countries, the prevalence and diversity of MDR phenotypes can substantially expand and become problematic (11,27); therefore, continued monitoring in the United States is warranted.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Current Activities of Fluoroquinolones against Gram-Negative Bacilli Using Centralized In Vitro Testing and Electronic Surveillance

Sahm

Critchley

Kelly

et al. 2001

Antimicrob Agents Chemother

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Given the propensity for Enterobacteriaceae and clinically significant nonfermentative gram-negative bacilli to acquire antimicrobial resistance, consistent surveillance of the activities of agents commonly prescribed to treat infections arising from these organisms is imperative. This study determined the activities of two fluoroquinolones, levofloxacin and ciprofloxacin, and seven comparative agents against recent clinical isolates of Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia using two surveillance strategies: 1) centralized in vitro susceptibility testing of isolates collected from 27 hospital laboratories across the United States and 2) analysis of data from The Surveillance Network Database-USA, an electronic surveillance network comprising more than 200 laboratories nationwide. Regardless of the surveillance method, Enterobacteriaceae, P. aeruginosa, and A. baumannii demonstrated similar rates of susceptibility to levofloxacin and ciprofloxacin. Susceptibilities to the fluoroquinolones approached or exceeded 90% for all Enterobacteriaceae except Providencia spp. (<65%). Approximately 70% of P. aeruginosa and 50% of A. baumanii isolates were susceptible to both fluoroquinolones. Among S. maltophilia isolates, 50% more isolates were susceptible to levofloxacin than to ciprofloxacin. Overall, the rate of ceftazidime nonsusceptibility among Enterobacteriaceae was 8.7%, with fluoroquinolone resistance rates notably higher among ceftazidime-nonsusceptible isolates than ceftazidime-susceptible ones. Multidrug-resistant isolates were present among all species tested but were most prevalent for Klebsiella pneumoniae and Enterobacter cloacae. No gram-negative isolates resistant only to a fluoroquinolone were encountered, regardless of species. Thus, while levofloxacin and ciprofloxacin have maintained potent activity against Enterobacteriaceae, the potential for fluoroquinolone resistance, the apparent association between fluoroquinolone and cephalosporin resistance, and the presence of multidrug resistance in every species examined emphasize the need to maintain active surveillance of resistance patterns among gram-negative bacilli.The potent activity of fluoroquinolones (FQs) against a myriad of gram-negative and gram-positive bacterial pathogens has fostered a decade of frequent and continued clinical use. Recently, levofloxacin has broadened the range of indications for FQs to include community-acquired respiratory tract infections attributable to penicillin-resistant Streptococcus pneumoniae. In spite of their success, concern remains regarding the development and increasing prevalence of resistance to FQs among human pathogens and colonizing bacterial species (12,23,24,25).A decline in the activity of FQs would be especially problematic in view of the ability of gram-negative bacilli to acquire resistance to all other classes of antimicrobials (4,5,10,11,14,15,17,20,22,29,30). This ability underscores the need to closely monitor FQ activity in the Uni...

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Acute Pyelonephritis in Adults

Efstathiou¹,

Pefanis²,

Tsioulos³

et al. 2003

Arch Intern Med

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Background: To formulate a classification tool for early recognition of patients admitted with acute pyelonephritis (AP) who are at high risk for failure of treatment or for death.Methods: A retrospective chart review of 225 patients (102 men) admitted with AP. We considered 13 potential risk factors in a multivariate analysis.Results: Recent hospitalization, previous use of antibiotics, and immunosuppression were found to be independent correlates of the prevalence of resistant pathogens in both sexes. Additional predictors included nephrolithiasis in women and a history of recurrent AP in men. Prolonged hospitalization should be expected for a man with diabetes and long-term catheterization who is older than 65 years or for a woman of any age with the same characteristics, when the initial treatment was changed according to the results of urine culture. For mortality prediction, we derived an integer-based scoring system with 6 points for shock, 4 for bedridden status, 4 for age greater than 65 years, and 3 for previous antibiotic treatment for men and 6 points for shock, 4 for bedridden status, 4 for age greater than 65 years, and 3 for immunosuppression for women. Among patients with at least 11 points, the risk for in-hospital death was 100% for men and 91% for women. Conclusions:Simple variables available at presentation can be used for risk stratification of patients with AP. The additional identification of certain risk factors by means of a carefully obtained history could contribute to early recognition of patients infected by resistant bacteria and optimize the selection of antimicrobial agents.

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Bacterial Resistance to Ciprofloxacin in Greece: Results from the National Electronic Surveillance System

Cited by 30 publications

References 21 publications

Biological Activity of <i>Spartium junceum</i> L. (Fabaceae) Aromatic Water

Biological Activity of <i>Spartium junceum</i> L. (Fabaceae) Aromatic Water

Evaluation of Current Activities of Fluoroquinolones against Gram-Negative Bacilli Using Centralized In Vitro Testing and Electronic Surveillance

Acute Pyelonephritis in Adults

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Bacterial Resistance to Ciprofloxacin in Greece: Results from the National Electronic Surveillance System

Cited by 30 publications

References 21 publications

Biological Activity of &lt;i&gt;Spartium junceum&lt;/i&gt; L. (Fabaceae) Aromatic Water

Biological Activity of &lt;i&gt;Spartium junceum&lt;/i&gt; L. (Fabaceae) Aromatic Water

Evaluation of Current Activities of Fluoroquinolones against Gram-Negative Bacilli Using Centralized In Vitro Testing and Electronic Surveillance

Acute Pyelonephritis in Adults

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Product

Resources

About

Biological Activity of <i>Spartium junceum</i> L. (Fabaceae) Aromatic Water

Biological Activity of <i>Spartium junceum</i> L. (Fabaceae) Aromatic Water